Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q15410251> ?p ?o }
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- Q15410251 subject Q6994655.
- Q15410251 subject Q7145140.
- Q15410251 subject Q8298471.
- Q15410251 subject Q8705273.
- Q15410251 abstract "Avibactam is a non-β-lactam β-lactamase inhibitor antibiotic being developed by Actavis jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime was approved by the FDA on February 25, 2015, for treating complicated urinary tract and complicated intra-abdominal infections caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant gram-negative bacterial pathogens.Increasing resistance to cephalosporins among Gram-(-) bacterial pathogens, especially among hospital-acquired infections, results in part from the production of beta lactamase enzymes that deactivate these antibiotics. While the co-administration of a beta lactamase inhibitor can restore antibacterial activity to the cephalorsporin, previously approved beta lactamase inhibitors such as tazobactam and Clavulanic acid do not inhibit important classes of beta lactamase including Klebsiella pneumoniae carbapenemases (KPCs), metallo-beta lactamases, and AmpC. Avibactam inhibits KPCs, AmpC, and some Class D beta lactamases, but is not active aganist NDM-1.".
- Q15410251 bioavailability "100.0".
- Q15410251 thumbnail Avibactam_structure_2.svg?width=300.
- Q15410251 wikiPageExternalLink 2013_A-1019.htm.
- Q15410251 wikiPageWikiLink Q12187.
- Q15410251 wikiPageWikiLink Q1368197.
- Q15410251 wikiPageWikiLink Q20973563.
- Q15410251 wikiPageWikiLink Q310286.
- Q15410251 wikiPageWikiLink Q343204.
- Q15410251 wikiPageWikiLink Q380775.
- Q15410251 wikiPageWikiLink Q415709.
- Q15410251 wikiPageWikiLink Q41873.
- Q15410251 wikiPageWikiLink Q423376.
- Q15410251 wikiPageWikiLink Q632006.
- Q15410251 wikiPageWikiLink Q6994655.
- Q15410251 wikiPageWikiLink Q7145140.
- Q15410251 wikiPageWikiLink Q731938.
- Q15410251 wikiPageWikiLink Q8298471.
- Q15410251 wikiPageWikiLink Q869588.
- Q15410251 wikiPageWikiLink Q8705273.
- Q15410251 wikiPageWikiLink Q9377.
- Q15410251 bioavailability "100.0".
- Q15410251 type ChemicalSubstance.
- Q15410251 type Drug.
- Q15410251 type ChemicalObject.
- Q15410251 type Thing.
- Q15410251 type Q8386.
- Q15410251 comment "Avibactam is a non-β-lactam β-lactamase inhibitor antibiotic being developed by Actavis jointly with AstraZeneca.".
- Q15410251 label "Avibactam".
- Q15410251 depiction Avibactam_structure_2.svg.