Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q15409403> ?p ?o }
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- Q15409403 subject Q8844626.
- Q15409403 subject Q8878420.
- Q15409403 subject Q8919936.
- Q15409403 abstract "Lometraline (INN; CP-14,368) is a drug which is an aminotetralin derivative. A structural modification of the investigative neuroleptic pinoxepin, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent (likely as an anticholinergic). However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, but clinical studies revealed no psychoactivity at the doses used and further investigation was suspended. However, further experimental modifications of the chemical structure of lometraline directly resulted in the discovery of tametraline, a potent inhibitor of the reuptake of dopamine and norepinephrine, which in turn led to the discovery of the now widely popular antidepressant sertraline, which, remarkably, acts contrarily as a selective serotonin reuptake inhibitor (SSRI).".
- Q15409403 atcPrefix "None".
- Q15409403 casNumber "39951-65-0".
- Q15409403 casSupplemental "34552-78-8 (hydrochloride)".
- Q15409403 iupacName "8-chloro-5-methoxy-N,N-dimethyl-1,2,3,4-tetrahydro-1-naphthalenamine".
- Q15409403 pubchem "34789".
- Q15409403 thumbnail Lometraline_structure.png?width=300.
- Q15409403 wikiPageWikiLink Q113259.
- Q15409403 wikiPageWikiLink Q170304.
- Q15409403 wikiPageWikiLink Q186242.
- Q15409403 wikiPageWikiLink Q1941660.
- Q15409403 wikiPageWikiLink Q2066956.
- Q15409403 wikiPageWikiLink Q206921.
- Q15409403 wikiPageWikiLink Q208144.
- Q15409403 wikiPageWikiLink Q334477.
- Q15409403 wikiPageWikiLink Q3579672.
- Q15409403 wikiPageWikiLink Q3706669.
- Q15409403 wikiPageWikiLink Q407617.
- Q15409403 wikiPageWikiLink Q420060.
- Q15409403 wikiPageWikiLink Q4596863.
- Q15409403 wikiPageWikiLink Q4859664.
- Q15409403 wikiPageWikiLink Q500256.
- Q15409403 wikiPageWikiLink Q62903.
- Q15409403 wikiPageWikiLink Q76560.
- Q15409403 wikiPageWikiLink Q7681179.
- Q15409403 wikiPageWikiLink Q824258.
- Q15409403 wikiPageWikiLink Q8386.
- Q15409403 wikiPageWikiLink Q8844626.
- Q15409403 wikiPageWikiLink Q8878420.
- Q15409403 wikiPageWikiLink Q8919936.
- Q15409403 wikiPageWikiLink Q910028.
- Q15409403 atcPrefix "None".
- Q15409403 casNumber "39951".
- Q15409403 casSupplemental "34552".
- Q15409403 iupacName "8".
- Q15409403 pubchem "34789".
- Q15409403 type ChemicalSubstance.
- Q15409403 type Drug.
- Q15409403 type ChemicalObject.
- Q15409403 type Thing.
- Q15409403 type Q8386.
- Q15409403 comment "Lometraline (INN; CP-14,368) is a drug which is an aminotetralin derivative. A structural modification of the investigative neuroleptic pinoxepin, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent (likely as an anticholinergic). However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, but clinical studies revealed no psychoactivity at the doses used and further investigation was suspended.".
- Q15409403 label "Lometraline".
- Q15409403 depiction Lometraline_structure.png.