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- Q15409386 subject Q9010304.
- Q15409386 subject Q9092116.
- Q15409386 abstract "Methylisopropyllysergamide (lysergic acid methylisopropyl amide, MIPLA) is an analogue of LSD that was originally discovered by Albert Hofmann at Sandoz during the original structure-activity research into LSD. It has subsequently been investigated in more detail by the team led by David E. Nichols at Purdue University. Methylisopropyllysergamide is a structural isomer of LSD, with the alkyl groups on the amide nitrogen having been subjected to a methylene shuffle. MIPLA and its ethylisopropyl homologue are the only simple N,N-dialkyl lysergamides that approach the potency of LSD itself, being around 1/3-1/2 the potency of LSD, while all other dialkyl analogues tested (dimethyl, dipropyl, methylethyl etc.) are only around 1/10 as potent as LSD, although some N-monoalkyl lysergamides such as the sec-butyl and t-butyl derivatives were also found to show an activity profile and potency comparable to LSD, and the mono-isopropyl derivative is only slightly weaker than MIPLA. Apart from its lower potency, the hallucinogenic effects of methylisopropyllysergamide are similar to those of LSD itself, and the main use for this drug has been in studies of the binding site at the 5-HT2A receptor through which LSD exerts most of its pharmacological effects.".
- Q15409386 atcPrefix "none".
- Q15409386 iupacName "(8β)-N-Isopropyl-N,6-dimethyl-9,10-didehydroergoline-8-carboxamide".
- Q15409386 thumbnail MIPLSD.svg?width=300.
- Q15409386 wikiPageWikiLink Q122338.
- Q15409386 wikiPageWikiLink Q14891424.
- Q15409386 wikiPageWikiLink Q208467.
- Q15409386 wikiPageWikiLink Q217741.
- Q15409386 wikiPageWikiLink Q23118.
- Q15409386 wikiPageWikiLink Q3017818.
- Q15409386 wikiPageWikiLink Q507154.
- Q15409386 wikiPageWikiLink Q6710119.
- Q15409386 wikiPageWikiLink Q6710121.
- Q15409386 wikiPageWikiLink Q7361732.
- Q15409386 wikiPageWikiLink Q9010304.
- Q15409386 wikiPageWikiLink Q9092116.
- Q15409386 atcPrefix "none".
- Q15409386 iupacName "-N-Isopropyl-N,6-dimethyl-9,10-didehydroergoline-8-carboxamide".
- Q15409386 type ChemicalSubstance.
- Q15409386 type Drug.
- Q15409386 type ChemicalObject.
- Q15409386 type Thing.
- Q15409386 type Q8386.
- Q15409386 comment "Methylisopropyllysergamide (lysergic acid methylisopropyl amide, MIPLA) is an analogue of LSD that was originally discovered by Albert Hofmann at Sandoz during the original structure-activity research into LSD. It has subsequently been investigated in more detail by the team led by David E. Nichols at Purdue University. Methylisopropyllysergamide is a structural isomer of LSD, with the alkyl groups on the amide nitrogen having been subjected to a methylene shuffle.".
- Q15409386 label "Methylisopropyllysergamide".
- Q15409386 depiction MIPLSD.svg.