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- Q14916213 subject Q8375682.
- Q14916213 abstract "Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a protein that in humans is encoded by the PAX6 gene.Pax6 is a transcription factor present during embryonic development. Theencoded protein contains two different binding sites that are known to bind DNAand function as regulators of gene transcription. It is a key regulatory gene of eyeand brain development. Within the brain, the protein is involved in development ofthe specialized cells that process smell. As a transcription factor, Pax6 activatesand/or deactivates gene expression patterns to ensure for proper development ofthe tissue. Mutations of the Pax6 gene are known to cause various disorders of theeyes. Two common disorders associated with a mutation are: aniridia, the absenceof the iris, and Peter’s anomaly, thinning and clouding of the cornea. Scientists havecreated a “tae” model using mice during which time the mouse does notexpress Pax6. The "knockout” model is eyeless or has very underdeveloped eyesfurther indicating Pax6 is required for proper eye development.".
- Q14916213 thumbnail Eyeless_(Pax-6)-_Drosophila_Model.jpg?width=300.
- Q14916213 wikiPageExternalLink NBK1378.
- Q14916213 wikiPageExternalLink index.html?query=pax6.
- Q14916213 wikiPageExternalLink NBK1360.
- Q14916213 wikiPageExternalLink 106210,194070,194072,607102,607108,106210,194070,194072,607102,607108.
- Q14916213 wikiPageExternalLink File:Eyeless_(Pax-6)-_Drosophila_Model.jpg.
- Q14916213 wikiPageWikiLink Q1093165.
- Q14916213 wikiPageWikiLink Q13048280.
- Q14916213 wikiPageWikiLink Q130888.
- Q14916213 wikiPageWikiLink Q13479514.
- Q14916213 wikiPageWikiLink Q1456827.
- Q14916213 wikiPageWikiLink Q177900.
- Q14916213 wikiPageWikiLink Q224180.
- Q14916213 wikiPageWikiLink Q272474.
- Q14916213 wikiPageWikiLink Q312154.
- Q14916213 wikiPageWikiLink Q373027.
- Q14916213 wikiPageWikiLink Q407384.
- Q14916213 wikiPageWikiLink Q4731548.
- Q14916213 wikiPageWikiLink Q5173.
- Q14916213 wikiPageWikiLink Q548719.
- Q14916213 wikiPageWikiLink Q609809.
- Q14916213 wikiPageWikiLink Q7187.
- Q14916213 wikiPageWikiLink Q8054.
- Q14916213 wikiPageWikiLink Q8375682.
- Q14916213 wikiPageWikiLink Q898769.
- Q14916213 wikiPageWikiLink Q903869.
- Q14916213 comment "Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a protein that in humans is encoded by the PAX6 gene.Pax6 is a transcription factor present during embryonic development. Theencoded protein contains two different binding sites that are known to bind DNAand function as regulators of gene transcription. It is a key regulatory gene of eyeand brain development.".
- Q14916213 label "PAX6".
- Q14916213 depiction Eyeless_(Pax-6)-_Drosophila_Model.jpg.