Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q14907881> ?p ?o }
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- Q14907881 subject Q7210802.
- Q14907881 abstract "ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.More recently, the ABCB5 molecule has been shown to be functionally relevant to carcinogenesis, demonstrated in colorectal cancer where it was shown to act as a mediator of 5-FU patient chemoresistance, and had a further direct role in tumorigenesis shown by shRNA-mediated colorectal cancer cell-line ABCB5 knockdowns that impeded tumorigenesis in human-to-mouse xenografts. These data revealed multiple roles for ABCB5 in cancer progression and chemoresistance, making it an attractive target for combined therapy. ABCB5 was similarly demonstrated in melanoma to be functionally important to multi-drug chemotherapy resistance, and tumor growth, controlling a proinflammatory signaling circuit utilizing TLR4, IL-1β, IL8 and CXCR1 signaling involving reciprocal paracrine interactions between the melanoma stem cell and tumor bulk population (in a rheostat manner termed "cancer stem cell rheostasis" by the authors). ABCB5 was shown to maintain the slow-cycling melanoma stem cells using this cytokine signaling loop, which became more differentiated upon ABCB5 interference (e.g. WFDC1 melanocyte differentiation marker increased, cancer cells were faster growing in vitro, tumors were more pigmented), or CXCR1 blockade (slow-cycling ABCB5+ cells entered the cell-cycle).In normal physiology ABCB5 was shown to be a functional marker for adult limbal stem cells of the cornea; ABCB5+ cells could regrow a human cornea on a mouse with limbal stem cell deficiency (LSCD - a blindness disease of the corneal limbus) while ABCB5- cells could not, indicating a therapeutic potential for treating some types of blindness. ABCB5 was further shown to be anti-apoptotic in these adult stem cells.".
- Q14907881 entrezgene "340273".
- Q14907881 wikiPageExternalLink b_viewarticle.php?3158333.
- Q14907881 wikiPageExternalLink 19725928.
- Q14907881 wikiPageWikiLink Q1146531.
- Q14907881 wikiPageWikiLink Q1377680.
- Q14907881 wikiPageWikiLink Q14875891.
- Q14907881 wikiPageWikiLink Q14914098.
- Q14907881 wikiPageWikiLink Q14916410.
- Q14907881 wikiPageWikiLink Q168291.
- Q14907881 wikiPageWikiLink Q17928830.
- Q14907881 wikiPageWikiLink Q18027847.
- Q14907881 wikiPageWikiLink Q180614.
- Q14907881 wikiPageWikiLink Q1950808.
- Q14907881 wikiPageWikiLink Q21163344.
- Q14907881 wikiPageWikiLink Q212354.
- Q14907881 wikiPageWikiLink Q238512.
- Q14907881 wikiPageWikiLink Q286958.
- Q14907881 wikiPageWikiLink Q55505.
- Q14907881 wikiPageWikiLink Q7187.
- Q14907881 wikiPageWikiLink Q7210802.
- Q14907881 wikiPageWikiLink Q8054.
- Q14907881 wikiPageWikiLink Q899229.
- Q14907881 type Biomolecule.
- Q14907881 type Protein.
- Q14907881 type Thing.
- Q14907881 type Q206229.
- Q14907881 type Q8054.
- Q14907881 comment "ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma.".
- Q14907881 label "ABCB5".