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- Q14907831 subject Q8395776.
- Q14907831 abstract "Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5), is a glycosylated monomeric metalloprotein enzyme expressed in mammals. It has a molecular weight of approximately 35kDa, a basic isoelectric point (7.6-9.5), and optimal activity in acidic conditions. TRAP is synthesized as latent proenzyme and activated by proteolytic cleavage and reduction. It is differentiated from other mammalian acid phosphatases by its resistance to inhibition by tartrate, molecular weight and characteristic purple colour.The mechanism of phosphate ester hydrolysis by TRAP is through a nucleophilic attack mechanism, whereby, catalysis occurs with the binding of a phosphate-substrate to the Fe2+ in the active site of TRAP. This is then followed by a nucleophilic attack by a hydroxide ligand on the bound phosphorus atom, resulting in cleavage of the phosphate ester bond and production of an alcohol. The exact identity and mechanism of the hydroxide ligand is unclear, but it is thought to be either a hydroxide that bridges the metal ions within the active site or a terminal hydroxide bound to Fe3+, with conflicting reports for both mechanisms.".
- Q14907831 entrezgene "54".
- Q14907831 wikiPageWikiLink Q1101143.
- Q14907831 wikiPageWikiLink Q12119506.
- Q14907831 wikiPageWikiLink Q14876614.
- Q14907831 wikiPageWikiLink Q14906495.
- Q14907831 wikiPageWikiLink Q14907671.
- Q14907831 wikiPageWikiLink Q165328.
- Q14907831 wikiPageWikiLink Q171877.
- Q14907831 wikiPageWikiLink Q1755568.
- Q14907831 wikiPageWikiLink Q176503.
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- Q14907831 wikiPageWikiLink Q184204.
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- Q14907831 wikiPageWikiLink Q189159.
- Q14907831 wikiPageWikiLink Q201299.
- Q14907831 wikiPageWikiLink Q210861.
- Q14907831 wikiPageWikiLink Q212410.
- Q14907831 wikiPageWikiLink Q224093.
- Q14907831 wikiPageWikiLink Q245759.
- Q14907831 wikiPageWikiLink Q308708.
- Q14907831 wikiPageWikiLink Q3142557.
- Q14907831 wikiPageWikiLink Q413283.
- Q14907831 wikiPageWikiLink Q422476.
- Q14907831 wikiPageWikiLink Q423350.
- Q14907831 wikiPageWikiLink Q424361.
- Q14907831 wikiPageWikiLink Q427071.
- Q14907831 wikiPageWikiLink Q43054.
- Q14907831 wikiPageWikiLink Q8047.
- Q14907831 wikiPageWikiLink Q828410.
- Q14907831 wikiPageWikiLink Q8395776.
- Q14907831 wikiPageWikiLink Q861645.
- Q14907831 wikiPageWikiLink Q898365.
- Q14907831 wikiPageWikiLink Q917177.
- Q14907831 type Biomolecule.
- Q14907831 type Protein.
- Q14907831 type Thing.
- Q14907831 type Q206229.
- Q14907831 type Q8054.
- Q14907831 comment "Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5), is a glycosylated monomeric metalloprotein enzyme expressed in mammals. It has a molecular weight of approximately 35kDa, a basic isoelectric point (7.6-9.5), and optimal activity in acidic conditions. TRAP is synthesized as latent proenzyme and activated by proteolytic cleavage and reduction.".
- Q14907831 label "Tartrate-resistant acid phosphatase".