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- Q14905207 subject Q8439272.
- Q14905207 abstract "Cytochrome P450 17A1, or steroid 17-alpha-monooxygenase, or 17α-hydroxylase/17,20 lyase/17,20 desmolase is an enzyme that in humans is encoded by the CYP17A1 gene. It is found in the zona reticularis of the adrenal cortex and zona fasciculata as well as gonadal tissues. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are generally regarded as monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids, including the remarkable carbon-carbon bond scission catalyzed by this enzyme. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.More specifically, CYP17A1 acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 of the steroid D ring (the hydroxylase activity), or acts upon 17-hydroxyprogesterone and 17-hydroxypregnenolone to split the side-chain off the steroid nucleus (the lyase activity).".
- Q14905207 entrezgene "1586".
- Q14905207 wikiPageWikiLink Q104116.
- Q14905207 wikiPageWikiLink Q11320751.
- Q14905207 wikiPageWikiLink Q11367.
- Q14905207 wikiPageWikiLink Q175901.
- Q14905207 wikiPageWikiLink Q177911.
- Q14905207 wikiPageWikiLink Q181257.
- Q14905207 wikiPageWikiLink Q189621.
- Q14905207 wikiPageWikiLink Q2064889.
- Q14905207 wikiPageWikiLink Q2273662.
- Q14905207 wikiPageWikiLink Q26963.
- Q14905207 wikiPageWikiLink Q277954.
- Q14905207 wikiPageWikiLink Q30612.
- Q14905207 wikiPageWikiLink Q321431.
- Q14905207 wikiPageWikiLink Q366868.
- Q14905207 wikiPageWikiLink Q407693.
- Q14905207 wikiPageWikiLink Q407727.
- Q14905207 wikiPageWikiLink Q412158.
- Q14905207 wikiPageWikiLink Q4127184.
- Q14905207 wikiPageWikiLink Q422519.
- Q14905207 wikiPageWikiLink Q422549.
- Q14905207 wikiPageWikiLink Q43656.
- Q14905207 wikiPageWikiLink Q62614.
- Q14905207 wikiPageWikiLink Q6901821.
- Q14905207 wikiPageWikiLink Q7180990.
- Q14905207 wikiPageWikiLink Q7187.
- Q14905207 wikiPageWikiLink Q79927.
- Q14905207 wikiPageWikiLink Q8047.
- Q14905207 wikiPageWikiLink Q8439272.
- Q14905207 type Biomolecule.
- Q14905207 type Protein.
- Q14905207 type Thing.
- Q14905207 type Q206229.
- Q14905207 type Q8054.
- Q14905207 comment "Cytochrome P450 17A1, or steroid 17-alpha-monooxygenase, or 17α-hydroxylase/17,20 lyase/17,20 desmolase is an enzyme that in humans is encoded by the CYP17A1 gene. It is found in the zona reticularis of the adrenal cortex and zona fasciculata as well as gonadal tissues. This gene encodes a member of the cytochrome P450 superfamily of enzymes.".
- Q14905207 label "CYP17A1".