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- Q1471601 subject Q7216294.
- Q1471601 abstract "Template:ForAn insulator is a genetic boundary element that blocks the interaction between enhancers and promoters. It is thought that an insulator must reside between the enhancer and promoter to inhibit their subsequent interactions. Insulators therefore determine the set of genes an enhancer can influence. The need for insulators arises where two adjacent genes on a chromosome have very different transcription patterns; it is critical that the inducing or repressing mechanisms of one do not interfere with the neighbouring gene. Insulators have also been found to cluster at the boundaries of topological association domains (TADs) and may have a role in partitioning the genome into "chromosome neighborhoods" - genomic regions within which regulation occurs.Insulator activity is thought to occur primarily through the 3D structure of DNA mediated by proteins including CTCF.".
- Q1471601 thumbnail Gene_enhancer.svg?width=300.
- Q1471601 wikiPageWikiLink Q177900.
- Q1471601 wikiPageWikiLink Q21163346.
- Q1471601 wikiPageWikiLink Q224093.
- Q1471601 wikiPageWikiLink Q37748.
- Q1471601 wikiPageWikiLink Q7162.
- Q1471601 wikiPageWikiLink Q7187.
- Q1471601 wikiPageWikiLink Q7216294.
- Q1471601 wikiPageWikiLink Q837783.
- Q1471601 wikiPageWikiLink Q913367.
- Q1471601 comment "Template:ForAn insulator is a genetic boundary element that blocks the interaction between enhancers and promoters. It is thought that an insulator must reside between the enhancer and promoter to inhibit their subsequent interactions. Insulators therefore determine the set of genes an enhancer can influence.".
- Q1471601 label "Insulator (genetics)".
- Q1471601 depiction Gene_enhancer.svg.