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- Q1445686 subject Q8573019.
- Q1445686 abstract "Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides. Moreover, ketolides are effective against macrolide-resistant bacteria, due to their ability to bind at two sites at the bacterial ribosome as well as having a structural modification that makes them poor substrates for efflux-pump mediated resistance. Ketolides block protein synthesis by binding to ribosomal subunits and may also inhibit the formation of newly forming ribosomes. According to a recent study comparing the actionof the classic macrolideserythromycin and azithromycinwithketolides, which are used to treatserious infections,the more powerfuldrugs (ketolides) were the more "leaky" inblocking the production ofproteins.The researchers were surprised to discoverthat ketolides, which are knownto be better antibiotics, allow formany more proteins to be madecompared to the older, lessefficient macrolides.As a result, it is now believed that allowingcells to make some proteinscould be much more damagingfor a microbe than not letting itmake any proteins at all.The findings may point the wayto better and more potentantibiotics.The only ketolide on the market at this moment is telithromycin, which is sold under the brand name of Ketek.Other ketolides in development include cethromycin and solithromycin.".
- Q1445686 thumbnail Telithromycin.png?width=300.
- Q1445686 wikiPageExternalLink ketek.html.
- Q1445686 wikiPageWikiLink Q1057705.
- Q1445686 wikiPageWikiLink Q12187.
- Q1445686 wikiPageWikiLink Q170744.
- Q1445686 wikiPageWikiLink Q213511.
- Q1445686 wikiPageWikiLink Q2736135.
- Q1445686 wikiPageWikiLink Q42244.
- Q1445686 wikiPageWikiLink Q422687.
- Q1445686 wikiPageWikiLink Q4859770.
- Q1445686 wikiPageWikiLink Q59078.
- Q1445686 wikiPageWikiLink Q7558263.
- Q1445686 wikiPageWikiLink Q8573019.
- Q1445686 comment "Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides.".
- Q1445686 label "Ketolide".
- Q1445686 depiction Telithromycin.png.