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- Q14225730 subject Q7163741.
- Q14225730 subject Q7214757.
- Q14225730 subject Q7217197.
- Q14225730 abstract "Cell-free fetal DNA (cffDNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of cffDNA provides a method of non-invasive prenatal diagnosis.cffDNA originates from the trophoblasts making up the placenta. It is estimated that 2-6% of the DNA in the maternal blood is fetal in origin. The fetal DNA is fragmented and makes its way into the maternal bloodstream via shedding of the placental microparticles into the maternal bloodstream (figure 1). Studies have shown that cffDNA can first be observed as early as 7 weeks gestation, and the amount of cffDNA increases as the pregnancy progresses. cffDNA diminishes quickly after the birth of the baby, so that it is no longer detectable in the maternal blood approximately 2 hours after birth. cffDNA is significantly smaller than the maternal DNA in the bloodstream, with fragments approximately 200bp in size. Many protocols to extract the fetal DNA from the maternal plasma use its size to distinguish it from the maternal DNA.Studies have looked at, and some even optimized, protocols for testing non-compatible RhD factors, sex determination for X-linked genetic disorders and testing for single gene disorders. Current studies are now looking at determining aneuploidies in the developing fetus. These protocols can be done earlier than the current prenatal testing methods, and have no risk of spontaneous abortion, unlike current prenatal testing methods. Non-invasive prenatal diagnosis (NIPD) has been implemented in the UK and parts of the US; it has clear benefits above the standard tests of chorionic villi sample (CVS) and amniocentesis which have procedure-related miscarriage risks of about 1 in 100 pregnancies and 1 in 200 pregnancies, respectively.As a method of prenatal diagnosis, cell-free fetal DNA techniques share the same ethical and practical issues, such as the possibility of prenatal sex discernment and sex selection.".
- Q14225730 wikiPageExternalLink www.ariosadx.com.
- Q14225730 wikiPageWikiLink Q1076497.
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- Q14225730 wikiPageWikiLink Q21192952.
- Q14225730 wikiPageWikiLink Q2253111.
- Q14225730 wikiPageWikiLink Q26513.
- Q14225730 wikiPageWikiLink Q28693.
- Q14225730 wikiPageWikiLink Q2914865.
- Q14225730 wikiPageWikiLink Q3808900.
- Q14225730 wikiPageWikiLink Q391556.
- Q14225730 wikiPageWikiLink Q473768.
- Q14225730 wikiPageWikiLink Q47715.
- Q14225730 wikiPageWikiLink Q529622.
- Q14225730 wikiPageWikiLink Q61335.
- Q14225730 wikiPageWikiLink Q625506.
- Q14225730 wikiPageWikiLink Q6784807.
- Q14225730 wikiPageWikiLink Q6968762.
- Q14225730 wikiPageWikiLink Q7163741.
- Q14225730 wikiPageWikiLink Q7214757.
- Q14225730 wikiPageWikiLink Q7217197.
- Q14225730 wikiPageWikiLink Q7240528.
- Q14225730 wikiPageWikiLink Q7430.
- Q14225730 wikiPageWikiLink Q873308.
- Q14225730 wikiPageWikiLink Q886549.
- Q14225730 wikiPageWikiLink Q976163.
- Q14225730 comment "Cell-free fetal DNA (cffDNA) is fetal DNA circulating freely in the maternal blood stream. It can be sampled by venipuncture on the mother. Analysis of cffDNA provides a method of non-invasive prenatal diagnosis.cffDNA originates from the trophoblasts making up the placenta. It is estimated that 2-6% of the DNA in the maternal blood is fetal in origin.".
- Q14225730 label "Cell-free fetal DNA".