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- Q1332167 subject Q9448303.
- Q1332167 abstract "In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. It is defined as the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing.The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma. VD is directly correlated with the amount of drug distributed into tissue; a higher VD indicates a greater amount of tissue distribution. A VD greater than the total volume of body water (approximately 42 liters in humans) is possible, and would indicate that the drug is highly distributed into tissue.In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma binding in the body's environment. Volume of distribution may be increased by renal failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). Conversely it may be decreased in dehydration.The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula.".
- Q1332167 wikiPageExternalLink VolDist1.html.
- Q1332167 wikiPageExternalLink avd.html.
- Q1332167 wikiPageExternalLink c0507.html.
- Q1332167 wikiPageExternalLink volume_of_distribution.html.
- Q1332167 wikiPageExternalLink index.html.
- Q1332167 wikiPageWikiLink Q12140.
- Q1332167 wikiPageWikiLink Q128406.
- Q1332167 wikiPageWikiLink Q15090168.
- Q1332167 wikiPageWikiLink Q153.
- Q1332167 wikiPageWikiLink Q167149.
- Q1332167 wikiPageWikiLink Q1781748.
- Q1332167 wikiPageWikiLink Q192197.
- Q1332167 wikiPageWikiLink Q193583.
- Q1332167 wikiPageWikiLink Q285166.
- Q1332167 wikiPageWikiLink Q39297.
- Q1332167 wikiPageWikiLink Q407308.
- Q1332167 wikiPageWikiLink Q407431.
- Q1332167 wikiPageWikiLink Q422438.
- Q1332167 wikiPageWikiLink Q476921.
- Q1332167 wikiPageWikiLink Q5283598.
- Q1332167 wikiPageWikiLink Q621636.
- Q1332167 wikiPageWikiLink Q79749.
- Q1332167 wikiPageWikiLink Q8386.
- Q1332167 wikiPageWikiLink Q898401.
- Q1332167 wikiPageWikiLink Q9448303.
- Q1332167 wikiPageWikiLink Q970208.
- Q1332167 comment "In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. It is defined as the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing.The VD of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma.".
- Q1332167 label "Volume of distribution".