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- Q12745592 subject Q7348588.
- Q12745592 subject Q8802898.
- Q12745592 subject Q9089708.
- Q12745592 abstract "Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate. They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors (see below).AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.iGluRs are tetramers (they are formed of four subunits). All subunits have a shared architecture with four domain layers: two extracellular clamshell domains called the N-terminal domain (NTD) and ligand-binding domain (LBD; which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD).".
- Q12745592 symbol "Lig_chan".
- Q12745592 thumbnail PDB_1s50_EBI.jpg?width=300.
- Q12745592 wikiPageWikiLink Q128406.
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- Q12745592 wikiPageWikiLink Q7348588.
- Q12745592 wikiPageWikiLink Q7662033.
- Q12745592 wikiPageWikiLink Q8802898.
- Q12745592 wikiPageWikiLink Q9089708.
- Q12745592 symbol "Lig_chan".
- Q12745592 type Biomolecule.
- Q12745592 type Protein.
- Q12745592 type Thing.
- Q12745592 type Q206229.
- Q12745592 type Q8054.
- Q12745592 comment "Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate. They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory.".
- Q12745592 label "Ionotropic glutamate receptor".
- Q12745592 depiction PDB_1s50_EBI.jpg.