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- Q1261151 subject Q7214529.
- Q1261151 subject Q9448303.
- Q1261151 abstract "Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication concentrations in blood. Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed. TDM aims at improving patient care by individually adjusting the dose of drugs for which clinical experience or clinical trials have shown it improved outcome in the general or special populations. It can be based on a priori pharmacogenetic, demographic and clinical information, and/or on the a posteriori measurement of blood concentrations of drugs (pharmacokinetic monitoring) or biological surrogate or end-point markers of effect (pharmacodynamic monitoring).There are numerous variables that influence the interpretation of drug concentration data: time, route and dose of drug given, time of blood sampling, handling and storage conditions, precision and accuracy of the analytical method, validity of pharmacokinetic models and assumptions, co-medications and clinical status of the patient (i.e. disease, renal/hepatic status, biologic tolerance to drug therapy, etc.).Many different professionals (physicians, clinical pharmacologists, clinical pharmacists, nurses, medical laboratory scientists, etc.) are involved with the various elements of drug concentration monitoring, which is a truly multidisciplinary process. Because failure to properly carry out any one of the components can severely affect the usefulness of using drug concentrations to optimize therapy, an organized approach to the overall process is critical.".
- Q1261151 wikiPageExternalLink www.iatdmct.org.
- Q1261151 wikiPageWikiLink Q1121713.
- Q1261151 wikiPageWikiLink Q121176.
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- Q1261151 wikiPageWikiLink Q323936.
- Q1261151 wikiPageWikiLink Q348260.
- Q1261151 wikiPageWikiLink Q39631.
- Q1261151 wikiPageWikiLink Q410400.
- Q1261151 wikiPageWikiLink Q410412.
- Q1261151 wikiPageWikiLink Q412909.
- Q1261151 wikiPageWikiLink Q415264.
- Q1261151 wikiPageWikiLink Q422482.
- Q1261151 wikiPageWikiLink Q576618.
- Q1261151 wikiPageWikiLink Q659446.
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- Q1261151 wikiPageWikiLink Q701216.
- Q1261151 wikiPageWikiLink Q708800.
- Q1261151 wikiPageWikiLink Q7119492.
- Q1261151 wikiPageWikiLink Q7214529.
- Q1261151 wikiPageWikiLink Q725307.
- Q1261151 wikiPageWikiLink Q7873.
- Q1261151 wikiPageWikiLink Q849994.
- Q1261151 wikiPageWikiLink Q9448303.
- Q1261151 comment "Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication concentrations in blood. Its main focus is on drugs with a narrow therapeutic range, i.e. drugs that can easily be under- or overdosed. TDM aims at improving patient care by individually adjusting the dose of drugs for which clinical experience or clinical trials have shown it improved outcome in the general or special populations.".
- Q1261151 label "Therapeutic drug monitoring".