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- Q1235785 subject Q6853484.
- Q1235785 subject Q7215468.
- Q1235785 subject Q8432427.
- Q1235785 abstract "Stiff person syndrome (SPS) is a rare neurologic disorder of unclear etiology characterized by progressive rigidity and stiffness. The stiffness primarily affects the truncal muscles and is superimposed by spasms, resulting in postural deformities. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms. The exact mechanism of the condition is unclear.SPS occurs in about one in a million people and is most commonly found in middle-aged people. A small minority of patients have the paraneoplastic variety of the condition. Variants of the condition, such as stiff-limb syndrome which primarily affects a specific limb, are often seen.SPS was first described in 1956. Diagnostic criteria were proposed in the 1960s and refined two decades later. In the 1990s and 2000s the roles of antibodies in the condition became more clear. SPS patients generally have GAD antibodies, which seldom occur in the general population. In addition to blood to tests for GAD, electromyography tests can help confirm the condition's presence.Benzodiazepine-class drugs are the most common treatment; they are used for symptom relief from stiffness. Other common treatments include Baclofen, intravenous immunoglobin and rituxan. There has been limited but encouraging success with stem-cell treatment.".
- Q1235785 icd10 "G25.8".
- Q1235785 icd9 "333.91".
- Q1235785 omim "3198".
- Q1235785 wikiPageExternalLink stiff-person-syndrome.
- Q1235785 wikiPageWikiLink Q103537.
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- Q1235785 wikiPageWikiLink Q6853484.
- Q1235785 wikiPageWikiLink Q7215468.
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- Q1235785 wikiPageWikiLink Q8432427.
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- Q1235785 icd "333.91".
- Q1235785 icd "G25.8".
- Q1235785 omim "3198".
- Q1235785 type Disease.
- Q1235785 type Thing.
- Q1235785 type Q12136.
- Q1235785 comment "Stiff person syndrome (SPS) is a rare neurologic disorder of unclear etiology characterized by progressive rigidity and stiffness. The stiffness primarily affects the truncal muscles and is superimposed by spasms, resulting in postural deformities. Chronic pain, impaired mobility, and lumbar hyperlordosis are common symptoms. The exact mechanism of the condition is unclear.SPS occurs in about one in a million people and is most commonly found in middle-aged people.".
- Q1235785 label "Stiff person syndrome".