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- Q123195 subject Q7204516.
- Q123195 subject Q8790354.
- Q123195 abstract "Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.It is approved for sale over the counter in Australia and the UK (recently re-classified to over the counter status), and is approved for the treatment of toenail fungus by prescription in other countries. It is not approved for the treatment of onychomycosis in the United States or Canada, but can be ordered from there by mail from other countries.".
- Q123195 atcPrefix "D01".
- Q123195 atcSuffix "AE16".
- Q123195 casNumber "78613-35-1".
- Q123195 chEBI "599440".
- Q123195 fdaUniiCode "AB0BHP2FH0".
- Q123195 iupacName "(±)-(2R*,6S*)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine".
- Q123195 pubchem "54260".
- Q123195 thumbnail Amorolfine.svg?width=300.
- Q123195 wikiPageWikiLink Q1154971.
- Q123195 wikiPageWikiLink Q143263.
- Q123195 wikiPageWikiLink Q223807.
- Q123195 wikiPageWikiLink Q29548.
- Q123195 wikiPageWikiLink Q408309.
- Q123195 wikiPageWikiLink Q420054.
- Q123195 wikiPageWikiLink Q5104316.
- Q123195 wikiPageWikiLink Q578726.
- Q123195 wikiPageWikiLink Q7204516.
- Q123195 wikiPageWikiLink Q7663812.
- Q123195 wikiPageWikiLink Q79899.
- Q123195 wikiPageWikiLink Q8790354.
- Q123195 wikiPageWikiLink Q917620.
- Q123195 atcPrefix "D01".
- Q123195 atcSuffix "AE16".
- Q123195 casNumber "78613".
- Q123195 chebi "599440".
- Q123195 iupacName "--2,6-dimethyl-4-{2-methyl-3-[4-phenyl]propyl}morpholine".
- Q123195 pubchem "54260".
- Q123195 unii "AB0BHP2FH0".
- Q123195 type ChemicalSubstance.
- Q123195 type Drug.
- Q123195 type ChemicalObject.
- Q123195 type Thing.
- Q123195 type Q8386.
- Q123195 comment "Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails).".
- Q123195 label "Amorolfine".
- Q123195 depiction Amorolfine.svg.