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- Q1187179 subject Q8376912.
- Q1187179 subject Q8805811.
- Q1187179 abstract "Denileukin diftitox (trade name Ontak) is an antineoplastic agent, an engineered protein combining Interleukin-2 and Diphtheria toxin. This can bind to Interleukin-2 receptors and introduce the diphtheria toxin into cells that express those receptors, killing the cells. In some Leukemias and Lymphomas malignant cells express these receptors, so denileukin diftitox can target these. In 1999 Ontak was approved by the U.S. Food and Drug Administration (FDA) for treatment of Cutaneous T-cell lymphoma (CTCL).A recent study at the University of Louisville found the drug caused many stage IV cutaneous T-cell lympomas to regress or stabilize extending patient life expectancy from about eight months to more than a year; a clinically significant increase especially given the guarded prognosis of patients with advanced disseminated cutaneous T-cell lymphoma (CTCL) and the generally poor response to other available treatments. There is some evidence tying it to vision loss and in 2006 the FDA added a black box warning to the drug's label.".
- Q1187179 atcPrefix "L01".
- Q1187179 atcSuffix "XX29".
- Q1187179 casNumber "173146-27-5".
- Q1187179 drugbank "DB00004".
- Q1187179 fdaUniiCode "25E79B5CTM".
- Q1187179 iupacName "Diphtheria toxin-Interleukin-2 fusion protein".
- Q1187179 wikiPageExternalLink ucm095661.htm.
- Q1187179 wikiPageExternalLink ONTAK_PI_3-1-06.pdf.
- Q1187179 wikiPageWikiLink Q1317143.
- Q1187179 wikiPageWikiLink Q14864515.
- Q1187179 wikiPageWikiLink Q204711.
- Q1187179 wikiPageWikiLink Q208414.
- Q1187179 wikiPageWikiLink Q29496.
- Q1187179 wikiPageWikiLink Q421580.
- Q1187179 wikiPageWikiLink Q5196687.
- Q1187179 wikiPageWikiLink Q5971673.
- Q1187179 wikiPageWikiLink Q8376912.
- Q1187179 wikiPageWikiLink Q879952.
- Q1187179 wikiPageWikiLink Q8805811.
- Q1187179 atcPrefix "L01".
- Q1187179 atcSuffix "XX29".
- Q1187179 casNumber "173146".
- Q1187179 drugbank "DB00004".
- Q1187179 iupacName "Diphtheria toxin-Interleukin-2 fusion protein".
- Q1187179 unii "9223372036854775807".
- Q1187179 type ChemicalSubstance.
- Q1187179 type Drug.
- Q1187179 type ChemicalObject.
- Q1187179 type Thing.
- Q1187179 type Q8386.
- Q1187179 comment "Denileukin diftitox (trade name Ontak) is an antineoplastic agent, an engineered protein combining Interleukin-2 and Diphtheria toxin. This can bind to Interleukin-2 receptors and introduce the diphtheria toxin into cells that express those receptors, killing the cells. In some Leukemias and Lymphomas malignant cells express these receptors, so denileukin diftitox can target these. In 1999 Ontak was approved by the U.S.".
- Q1187179 label "Denileukin diftitox".