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- Q1143638 subject Q7134791.
- Q1143638 abstract "Warfarin-induced skin necrosis (or, more generally, coumadin-induced skin necrosis or Anticoagulant-induced skin necrosis) is a condition in which skin and subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (coumadins, such as warfarin).Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants. The typical patient appears to be an obese, middle aged woman (median age 54 years, male to female ratio 1:3). This drug eruption usually occurs between the third and tenth days of therapy with warfarin derivatives. The first symptoms are pain and redness in the affected area. As they progress, lesions develop a sharp border and become petechial, then hard and purpuric. They may then resolve or progress to form large, irregular, bloody bullae with eventual necrosis and slow-healing eschar formation. Favored sites are breasts, thighs, buttocks and penis, all areas with subcutaneous fat. In rare cases, the fascia and muscle are involved.Development of the syndrome is associated with the use of large loading doses at the start of treatment.".
- Q1143638 icd10 "Y44.2".
- Q1143638 icd9 "E934.2".
- Q1143638 thumbnail Coumarin-induced_skin_necrosis.jpg?width=300.
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- Q1143638 icd "E934.2".
- Q1143638 icd "Y44.2".
- Q1143638 name "Warfarin necrosis".
- Q1143638 type Disease.
- Q1143638 type Thing.
- Q1143638 type Q12136.
- Q1143638 comment "Warfarin-induced skin necrosis (or, more generally, coumadin-induced skin necrosis or Anticoagulant-induced skin necrosis) is a condition in which skin and subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (coumadins, such as warfarin).Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants.".
- Q1143638 label "Warfarin necrosis".
- Q1143638 depiction Coumarin-induced_skin_necrosis.jpg.
- Q1143638 name "Warfarin necrosis".