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- Q1091921 subject Q7336348.
- Q1091921 subject Q8431759.
- Q1091921 subject Q8593001.
- Q1091921 subject Q9052781.
- Q1091921 abstract "Cilengitide (EMD 121974) is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.The European Medicines Agency has granted cilengitide orphan drug status.Cilengitide seems to function by inhibiting the FAK/src/AKT pathway and inducing apoptosis in endothelial cells. Preclinical studies in mice of cilengitide were able to demonstrate efficacious tumor regression.In a rat xenograft model, cilengitide was able to potentiate the cytotoxic effects of radiation when cilengitide was administered prior to radiation therapy. When combined with radiation, inhibition of integrin expression by cilengitide synergistically improves the cytotoxic effects of ionizing radiation for glioblastoma.".
- Q1091921 iupacName "2-[(2S,5R,8S,11S)-5-benzyl-11-{3-[(diaminomethylidene)amino]propyl}-7-methyl-3,6,9,12,15-pentaoxo-8-(propan-2-yl)-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid".
- Q1091921 thumbnail Cilengitide.svg?width=300.
- Q1091921 wikiPageWikiLink Q10676833.
- Q1091921 wikiPageWikiLink Q130146.
- Q1091921 wikiPageWikiLink Q1367466.
- Q1091921 wikiPageWikiLink Q15333532.
- Q1091921 wikiPageWikiLink Q156959.
- Q1091921 wikiPageWikiLink Q157808.
- Q1091921 wikiPageWikiLink Q172847.
- Q1091921 wikiPageWikiLink Q18028029.
- Q1091921 wikiPageWikiLink Q18252301.
- Q1091921 wikiPageWikiLink Q282142.
- Q1091921 wikiPageWikiLink Q2973.
- Q1091921 wikiPageWikiLink Q423650.
- Q1091921 wikiPageWikiLink Q539568.
- Q1091921 wikiPageWikiLink Q7336348.
- Q1091921 wikiPageWikiLink Q8431759.
- Q1091921 wikiPageWikiLink Q8593001.
- Q1091921 wikiPageWikiLink Q9052781.
- Q1091921 iupacname "2".
- Q1091921 type ChemicalCompound.
- Q1091921 type ChemicalSubstance.
- Q1091921 type ChemicalObject.
- Q1091921 type Thing.
- Q1091921 type Q11173.
- Q1091921 comment "Cilengitide (EMD 121974) is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology.".
- Q1091921 label "Cilengitide".
- Q1091921 depiction Cilengitide.svg.