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- Q10918457 subject Q8668627.
- Q10918457 subject Q9532257.
- Q10918457 abstract "Synthesis of morphine-like alkaloids in chemistry describes the total synthesis of the natural morphinan class of alkaloids that includes codeine, morphine, oripavine, and thebaine and the closely related semisynthetic analogs buprenorphine, hydrocodone, isocodeine, naltrexone, naloxone, nalbuphine, and oxycodone.The structure of morphine is not particularly complex, however the electrostatic polarization of adjacent bonded atoms does not alternate uniformly throughout the structure. This "dissonant connectivity" makes bond formation more difficult and therefore significantly complicates any synthetic strategy that is applied to this family of molecules.The first morphine total synthesis, devised by Marshall D. Gates, Jr. in 1952 remains a widely used example of total synthesis. This synthesis took a total of 31 steps and proceeded in 0.06% over all yield. The dihydrocodeinone synthesis of Kenner C. Rice is one of the most efficient and proceeds in 30% overall yield in 14 steps.Several other syntheses were reported, notably by the research groups of Evans, Fuchs, Parker, Overman, Mulzer-Trauner, White, Taber, Trost, Fukuyama, Guillou, Stork, and Magnus.".
- Q10918457 thumbnail Morphin_-_Morphine.svg?width=300.
- Q10918457 wikiPageExternalLink gm-2006-01n31.pdf.
- Q10918457 wikiPageExternalLink morphine.
- Q10918457 wikiPageWikiLink Q1057268.
- Q10918457 wikiPageWikiLink Q109369.
- Q10918457 wikiPageWikiLink Q11203791.
- Q10918457 wikiPageWikiLink Q16842168.
- Q10918457 wikiPageWikiLink Q174723.
- Q10918457 wikiPageWikiLink Q2329.
- Q10918457 wikiPageWikiLink Q277979.
- Q10918457 wikiPageWikiLink Q282902.
- Q10918457 wikiPageWikiLink Q3121632.
- Q10918457 wikiPageWikiLink Q375669.
- Q10918457 wikiPageWikiLink Q407535.
- Q10918457 wikiPageWikiLink Q407721.
- Q10918457 wikiPageWikiLink Q409587.
- Q10918457 wikiPageWikiLink Q410169.
- Q10918457 wikiPageWikiLink Q411441.
- Q10918457 wikiPageWikiLink Q420639.
- Q10918457 wikiPageWikiLink Q49351.
- Q10918457 wikiPageWikiLink Q6085506.
- Q10918457 wikiPageWikiLink Q6122828.
- Q10918457 wikiPageWikiLink Q644785.
- Q10918457 wikiPageWikiLink Q725840.
- Q10918457 wikiPageWikiLink Q765613.
- Q10918457 wikiPageWikiLink Q81225.
- Q10918457 wikiPageWikiLink Q8668627.
- Q10918457 wikiPageWikiLink Q901154.
- Q10918457 wikiPageWikiLink Q901232.
- Q10918457 wikiPageWikiLink Q901783.
- Q10918457 wikiPageWikiLink Q9532257.
- Q10918457 comment "Synthesis of morphine-like alkaloids in chemistry describes the total synthesis of the natural morphinan class of alkaloids that includes codeine, morphine, oripavine, and thebaine and the closely related semisynthetic analogs buprenorphine, hydrocodone, isocodeine, naltrexone, naloxone, nalbuphine, and oxycodone.The structure of morphine is not particularly complex, however the electrostatic polarization of adjacent bonded atoms does not alternate uniformly throughout the structure.".
- Q10918457 label "Total synthesis of morphine and related alkaloids".
- Q10918457 depiction Morphin_-_Morphine.svg.