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- Q1088175 subject Q13259243.
- Q1088175 subject Q9527776.
- Q1088175 subject Q9536694.
- Q1088175 abstract "Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture composition"). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.Family of polypeptides with attached fatty acid; cationic detergent at physiological pH, both hydrophilic and hydrophobic propertiesBactericidal for gram-negative; little to no effect on gram-positive, since cell wall is too thick to permit access to membrane".
- Q1088175 atcPrefix "A07".
- Q1088175 atcSuffix "AA05".
- Q1088175 casNumber "1405-20-5".
- Q1088175 drugbank "DB00781".
- Q1088175 iupacName "N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide".
- Q1088175 pubchem "5702105".
- Q1088175 thumbnail Polymyxin_B1.svg?width=300.
- Q1088175 wikiPageWikiLink Q11193.
- Q1088175 wikiPageWikiLink Q1320251.
- Q1088175 wikiPageWikiLink Q132209.
- Q1088175 wikiPageWikiLink Q132229.
- Q1088175 wikiPageWikiLink Q13259243.
- Q1088175 wikiPageWikiLink Q168115.
- Q1088175 wikiPageWikiLink Q191154.
- Q1088175 wikiPageWikiLink Q1949025.
- Q1088175 wikiPageWikiLink Q258248.
- Q1088175 wikiPageWikiLink Q29548.
- Q1088175 wikiPageWikiLink Q334637.
- Q1088175 wikiPageWikiLink Q36496.
- Q1088175 wikiPageWikiLink Q389172.
- Q1088175 wikiPageWikiLink Q420054.
- Q1088175 wikiPageWikiLink Q423765.
- Q1088175 wikiPageWikiLink Q430024.
- Q1088175 wikiPageWikiLink Q432083.
- Q1088175 wikiPageWikiLink Q632006.
- Q1088175 wikiPageWikiLink Q640448.
- Q1088175 wikiPageWikiLink Q6994170.
- Q1088175 wikiPageWikiLink Q857288.
- Q1088175 wikiPageWikiLink Q9527776.
- Q1088175 wikiPageWikiLink Q9536694.
- Q1088175 atcPrefix "A07".
- Q1088175 atcSuffix "AA05".
- Q1088175 casNumber "1405".
- Q1088175 drugbank "DB00781".
- Q1088175 iupacName "N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris-15-benzyl-3--12--2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide".
- Q1088175 pubchem "5702105".
- Q1088175 type ChemicalSubstance.
- Q1088175 type Drug.
- Q1088175 type ChemicalObject.
- Q1088175 type Thing.
- Q1088175 type Q8386.
- Q1088175 comment "Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture composition"). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death.".
- Q1088175 label "Polymyxin B".
- Q1088175 depiction Polymyxin_B1.svg.