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- Q1022877 subject Q7170959.
- Q1022877 abstract "The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality. It was conducted between 1986 and 1989 and included over 1700 patients in 27 centres. The study found that the tested drugs increased mortality instead of lowering it as was expected. The publication of these results in 1991/92, in combination with large follow-up studies for drugs that had not been tested in CAST, led to a paradigm shift in the treatment of MI patients. Class I and III antiarrhythmics are now only used with extreme caution after MI, or they are contraindicated completely. Heart Rhythm Society Distinguished Scientist D. George Wyse was a member of the CAST trial's steering and executive committees.".
- Q1022877 wikiPageWikiLink Q1162673.
- Q1022877 wikiPageWikiLink Q12152.
- Q1022877 wikiPageWikiLink Q1329925.
- Q1022877 wikiPageWikiLink Q1436668.
- Q1022877 wikiPageWikiLink Q188151.
- Q1022877 wikiPageWikiLink Q189331.
- Q1022877 wikiPageWikiLink Q241549.
- Q1022877 wikiPageWikiLink Q421381.
- Q1022877 wikiPageWikiLink Q514534.
- Q1022877 wikiPageWikiLink Q5203604.
- Q1022877 wikiPageWikiLink Q58702.
- Q1022877 wikiPageWikiLink Q641303.
- Q1022877 wikiPageWikiLink Q689971.
- Q1022877 wikiPageWikiLink Q6973027.
- Q1022877 wikiPageWikiLink Q7170959.
- Q1022877 wikiPageWikiLink Q840646.
- Q1022877 wikiPageWikiLink Q904071.
- Q1022877 comment "The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality. It was conducted between 1986 and 1989 and included over 1700 patients in 27 centres. The study found that the tested drugs increased mortality instead of lowering it as was expected.".
- Q1022877 label "Cardiac Arrhythmia Suppression Trial".