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- nrn3869 date "December 2014".
- nrn3869 doi "10.1038/nrn3869".
- nrn3869 isCitedBy Eric_J._Nestler.
- nrn3869 issue "12".
- nrn3869 journal "Nat. Rev. Neurosci.".
- nrn3869 pages "768–769".
- nrn3869 pmid "25409693".
- nrn3869 quote "Chronic exposure to stress or drugs of abuse causes widespread changes in the activity of chromatin remodelling enzymes. However, it has been difficult to determine the relative functional importance of drug- or stress-induced epigenetic modifications of individual genes. Nestler and colleagues have now employed gene- and brain-region-specific chromatin remodelling to examine the role of one particular gene, [ΔFosB], in addiction- and depression-related changes in the brain and behaviour. ... This study shows that single epigenetic modifications can modulate both [ΔFosB] expression and its behavioural effects. A similar approach may be used to target other genes of interest and elucidate further the changes in molecular pathways that underlie psychiatric disorders.ORIGINAL RESEARCH PAPER Heller, E. A. et al. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nature Neurosci. http://dx.doi.org/10.1038/nn.3871".
- nrn3869 title "Psychiatric disorders: a feat of epigenetic engineering".
- nrn3869 vauthors "Whalley K".
- nrn3869 volume "15".