DBpedia 2016-04

Matches in DBpedia 2016-04 for { <http://doi.org/10.1038/nrn3111> ?p ?o }

Showing triples 1 to 46 of 46 with 100 triples per page.

nrn3111 author "Robison AJ, Nestler EJ".
nrn3111 date "Nov 2011".
nrn3111 date "November 2011".
nrn3111 doi "10.1038/nrn3111".
nrn3111 first1 "Alfred J.".
nrn3111 first2 "Eric J.".
nrn3111 isCitedBy Addiction.
nrn3111 isCitedBy Amphetamine.
nrn3111 isCitedBy Behavioral_addiction.
nrn3111 isCitedBy Epigenetics.
nrn3111 isCitedBy Eric_J._Nestler.
nrn3111 isCitedBy Ethanol.
nrn3111 isCitedBy FOSB.
nrn3111 isCitedBy JunD.
nrn3111 isCitedBy MDMA.
nrn3111 isCitedBy Mesolimbic_pathway.
nrn3111 isCitedBy Methamphetamine.
nrn3111 isCitedBy Methylphenidate.
nrn3111 isCitedBy NF-κB.
nrn3111 isCitedBy Neuropharmacology.
nrn3111 isCitedBy Nucleus_accumbens.
nrn3111 isCitedBy Opioid_addiction_and_dependence.
nrn3111 isCitedBy Substance_dependence.
nrn3111 isCitedBy Substance_use_disorder.
nrn3111 isCitedBy Sugar_addiction.
nrn3111 issue "11".
nrn3111 journal "Nat. Rev. Neurosci".
nrn3111 journal "Nat. Rev. Neurosci.".
nrn3111 journal "Nature Reviews Neuroscience".
nrn3111 journal "Nature Reviews. Neuroscience".
nrn3111 last1 "Robison".
nrn3111 last2 "Nestler".
nrn3111 pages "623–37".
nrn3111 pages "623–637".
nrn3111 pmc "3272277".
nrn3111 pmid "21989194".
nrn3111 quote "ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states. ... 95% of NAc neurons are GABAergic MSNs , which can be further differentiated into those MSNs that express the D1 dopamine receptor and express dynorphin and substance P and those that express the D2 dopamine receptor and express enkephalin132. Drug induction of ΔFosB133,134, and the effects of ΔFosB and G9a on cell morphology and behavior, differ between D1-type and D2-type MSNs135, and neuronal activity of these two cell types causes opposing effects on the rewarding properties of cocaine131. ... About 1–2% of NAc neurons are aspiny large cholinergic interneurons, which have been shown to play an important role in cocaine reward130, and a similar number are GABAergic interneurons, the function of which are less well understood.".
nrn3111 quote "ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states. ... ΔFosB serves as one of the master control proteins governing this structural plasticity.".
nrn3111 quote "ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states.".
nrn3111 quote "ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the or blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states.".
nrn3111 quote "ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states. ... ΔFosB serves as one of the master control proteins governing this structural plasticity.".
nrn3111 quote "ΔFosB serves as one of the master control proteins governing this structural plasticity.".
nrn3111 title "Transcriptional and epigenetic mechanisms of addiction".
nrn3111 vauthors "Robison AJ, Nestler EJ".
nrn3111 volume "12".
nrn3111 year "2011".