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- Zoptarelin_doxorubicin abstract "Zoptarelin doxorubicin consists of doxorubicin linked to a small peptide agonist to the luteinizing hormone-releasing hormone (LHRH) receptor. It has been developed as a potential treatment for a number of human cancers. The LHRH receptor is aberrantly present on the cell surface of approximately 80% of endometrial and ovarian cancers, 86% of prostate cancers and about 50% of breast cancers. Whereas in normal tissues, expression of this receptor is mainly confined to the pituitary gland, reproductive organs and hematopoietic stem cells. To a lesser extent the LHRH receptor is also found on the surface of bladder, colorectal, and pancreatic cancers, sarcomas, lymphomas, melanomas, and renal cell carcinomas.The proposed method of action is that upon administration zoptarelin doxorubicin binds to the LHRH receptor and is subsequently internalized, concentrating the toxic doxorubicin within cancer cells and the small subset of normal tissues, as opposed to the completely systemic distribution observed with untargeted chemotherapeutics. The specific targeting of the doxorubicin to LHRH receptor bearing cells is also proposed to reduce the cardiotoxicity observed in the administration of unconjugated doxorubicin.Zoptarelin doxorubicin is also known as AEZS-108 (previously AN-152).Zoptarelin doxorubicin was developed by Andrew V. Schally while at the Tulane University School of Medicine, New Orleans and subsequently at the Sylvester Comprehensive Cancer Center, University of Miami. The U.S. Food and Drug Administration (FDA) has granted it orphan drug status for ovarian cancer and endometrial cancer.".
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- Zoptarelin_doxorubicin wikiPageID "28796495".
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- Zoptarelin_doxorubicin wikiPageRevisionID "707012641".
- Zoptarelin_doxorubicin wikiPageWikiLink Andrew_Schally.
- Zoptarelin_doxorubicin wikiPageWikiLink Category:Anthracyclines.
- Zoptarelin_doxorubicin wikiPageWikiLink Category:Experimental_cancer_drugs.
- Zoptarelin_doxorubicin wikiPageWikiLink Doxorubicin.
- Zoptarelin_doxorubicin wikiPageWikiLink Endometrial_cancer.
- Zoptarelin_doxorubicin wikiPageWikiLink Food_and_Drug_Administration.
- Zoptarelin_doxorubicin wikiPageWikiLink Gonadotropin-releasing_hormone.
- Zoptarelin_doxorubicin wikiPageWikiLink Ovarian_cancer.
- Zoptarelin_doxorubicin wikiPageWikiLink Tulane_University_School_of_Medicine.
- Zoptarelin_doxorubicin wikiPageWikiLinkText "Zoptarelin doxorubicin".
- Zoptarelin_doxorubicin atcPrefix "None".
- Zoptarelin_doxorubicin c "91".
- Zoptarelin_doxorubicin chemspiderid "17290938".
- Zoptarelin_doxorubicin h "117".
- Zoptarelin_doxorubicin inchi "1".
- Zoptarelin_doxorubicin inchikey "OOUACICUAVTCEC-LZHWUUGEBP".
- Zoptarelin_doxorubicin iupacName "([2-[-4-[-4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-oxo-ethyl] 5-(5R)-6-[[(1S)-1-[[(1S)-1-[(2S)-2-[(2-amino-2-oxo-ethyl)carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-5-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-oxo-hexyl]amino]-5-oxo-pentanoate)".
- Zoptarelin_doxorubicin legalStatus "Investigational".
- Zoptarelin_doxorubicin n "19".
- Zoptarelin_doxorubicin o "26".
- Zoptarelin_doxorubicin pubchem "16134409".
- Zoptarelin_doxorubicin smiles "CC1CO".
- Zoptarelin_doxorubicin stdinchi "1".
- Zoptarelin_doxorubicin stdinchikey "OOUACICUAVTCEC-LZHWUUGESA-N".
- Zoptarelin_doxorubicin synonyms "AN-152; AEZS-108".
- Zoptarelin_doxorubicin width "250".
- Zoptarelin_doxorubicin wikiPageUsesTemplate Template:Infobox_drug.
- Zoptarelin_doxorubicin wikiPageUsesTemplate Template:Peptidergics.
- Zoptarelin_doxorubicin wikiPageUsesTemplate Template:Reflist.
- Zoptarelin_doxorubicin subject Category:Anthracyclines.
- Zoptarelin_doxorubicin subject Category:Experimental_cancer_drugs.
- Zoptarelin_doxorubicin type ChemicalSubstance.
- Zoptarelin_doxorubicin type Drug.
- Zoptarelin_doxorubicin type Drug.
- Zoptarelin_doxorubicin type ChemicalObject.
- Zoptarelin_doxorubicin type Thing.
- Zoptarelin_doxorubicin type Q8386.
- Zoptarelin_doxorubicin comment "Zoptarelin doxorubicin consists of doxorubicin linked to a small peptide agonist to the luteinizing hormone-releasing hormone (LHRH) receptor. It has been developed as a potential treatment for a number of human cancers. The LHRH receptor is aberrantly present on the cell surface of approximately 80% of endometrial and ovarian cancers, 86% of prostate cancers and about 50% of breast cancers.".
- Zoptarelin_doxorubicin label "Zoptarelin doxorubicin".
- Zoptarelin_doxorubicin sameAs Q4651377.
- Zoptarelin_doxorubicin sameAs m.0ddcnyf.
- Zoptarelin_doxorubicin sameAs Q4651377.
- Zoptarelin_doxorubicin wasDerivedFrom Zoptarelin_doxorubicin?oldid=707012641.
- Zoptarelin_doxorubicin depiction Zoptarelin_doxorubicin.svg.
- Zoptarelin_doxorubicin isPrimaryTopicOf Zoptarelin_doxorubicin.