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- Wortmannin abstract "Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii,is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in vitro for the class I, II, and III PI3K members although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PKcs, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations , Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation.".
- Wortmannin thumbnail Wortmannin_chemical_structure.png?width=300.
- Wortmannin wikiPageExternalLink ?ligand=KWT.
- Wortmannin wikiPageExternalLink wortmannin.htm.
- Wortmannin wikiPageExternalLink overview.html.
- Wortmannin wikiPageID "1607079".
- Wortmannin wikiPageLength "6883".
- Wortmannin wikiPageOutDegree "30".
- Wortmannin wikiPageRevisionID "697382309".
- Wortmannin wikiPageWikiLink 1-phosphatidylinositol_4-kinase.
- Wortmannin wikiPageWikiLink Category:Acetate_esters.
- Wortmannin wikiPageWikiLink Category:Furans.
- Wortmannin wikiPageWikiLink Category:Lactones.
- Wortmannin wikiPageWikiLink Category:Phosphoinositide_3-kinase_inhibitors.
- Wortmannin wikiPageWikiLink Cell_biology.
- Wortmannin wikiPageWikiLink Class_III_PI_3-kinase.
- Wortmannin wikiPageWikiLink Class_II_PI_3-kinases.
- Wortmannin wikiPageWikiLink Class_I_PI_3-kinases.
- Wortmannin wikiPageWikiLink Covalent_bond.
- Wortmannin wikiPageWikiLink DNA-PKcs.
- Wortmannin wikiPageWikiLink DNA_repair.
- Wortmannin wikiPageWikiLink Fermentek.
- Wortmannin wikiPageWikiLink IC50.
- Wortmannin wikiPageWikiLink LY294002.
- Wortmannin wikiPageWikiLink Mechanistic_target_of_rapamycin.
- Wortmannin wikiPageWikiLink Mitogen-activated_protein_kinase.
- Wortmannin wikiPageWikiLink Myosin_light-chain_kinase.
- Wortmannin wikiPageWikiLink Penicillium_funiculosum.
- Wortmannin wikiPageWikiLink Phosphoinositide_3-kinase.
- Wortmannin wikiPageWikiLink Phosphoinositide_3-kinase_inhibitor.
- Wortmannin wikiPageWikiLink Polo-like_kinase.
- Wortmannin wikiPageWikiLink Protein_Data_Bank.
- Wortmannin wikiPageWikiLink Receptor-mediated_endocytosis.
- Wortmannin wikiPageWikiLink Talaromyces_wortmannii.
- Wortmannin wikiPageWikiLink Wortmannin.
- Wortmannin wikiPageWikiLinkText "Wortmannin".
- Wortmannin wikiPageWikiLinkText "Wortmannin#PX-866".
- Wortmannin wikiPageWikiLinkText "wortmannin".
- Wortmannin imagefile "Wortmannin chemical structure.png".
- Wortmannin verifiedfields "changed".
- Wortmannin verifiedrevid "393946468".
- Wortmannin watchedfields "changed".
- Wortmannin wikiPageUsesTemplate Template:Cascite.
- Wortmannin wikiPageUsesTemplate Template:Chembox.
- Wortmannin wikiPageUsesTemplate Template:Chembox_Hazards.
- Wortmannin wikiPageUsesTemplate Template:Chembox_Identifiers.
- Wortmannin wikiPageUsesTemplate Template:Chembox_Properties.
- Wortmannin wikiPageUsesTemplate Template:Chemspidercite.
- Wortmannin wikiPageUsesTemplate Template:Citation_needed.
- Wortmannin wikiPageUsesTemplate Template:Ebicite.
- Wortmannin wikiPageUsesTemplate Template:Reflist.
- Wortmannin wikiPageUsesTemplate Template:Serotonin_antagonists.
- Wortmannin wikiPageUsesTemplate Template:Stdinchicite.
- Wortmannin wikiPageUsesTemplate Template:Update-section.
- Wortmannin subject Category:Acetate_esters.
- Wortmannin subject Category:Furans.
- Wortmannin subject Category:Lactones.
- Wortmannin subject Category:Phosphoinositide_3-kinase_inhibitors.
- Wortmannin hypernym Inhibitor.
- Wortmannin type ChemicalCompound.
- Wortmannin type ChemicalSubstance.
- Wortmannin type Drug.
- Wortmannin type Chemical.
- Wortmannin type Ester.
- Wortmannin type Heterocycle.
- Wortmannin type Inhibitor.
- Wortmannin type Lactone.
- Wortmannin type ChemicalObject.
- Wortmannin type Thing.
- Wortmannin type Q11173.
- Wortmannin comment "Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii,is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor.".
- Wortmannin label "Wortmannin".
- Wortmannin sameAs Q423565.
- Wortmannin sameAs Wortmannin.
- Wortmannin sameAs ورتمانین.
- Wortmannin sameAs m.05g6p6.
- Wortmannin sameAs Вортманнин.
- Wortmannin sameAs Vortmanin.
- Wortmannin sameAs Vortmanin.
- Wortmannin sameAs Q423565.
- Wortmannin wasDerivedFrom Wortmannin?oldid=697382309.
- Wortmannin depiction Wortmannin_chemical_structure.png.
- Wortmannin isPrimaryTopicOf Wortmannin.