Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/WIN_55,212-2> ?p ?o }
- WIN_55,212-2 abstract "WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure.WIN 55,212-2 is a potent cannabinoid receptor agonist that has been found to be a potent analgesic in a rat model of neuropathic pain. It activates p42 and p44 MAP kinase via receptor-mediated signaling.At 5 µM WIN 55,212-2 inhibit ATP production in sperm in a CB1 receptor-dependent fashion.WIN 55,212-2, along with HU-210 and JWH-133, may prevent the inflammation caused by amyloid beta proteins involved in Alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through agonist action at cannabinoid receptors, which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglial activation in rat models.WIN 55,212-2 is a full agonist at the CB1 cannabinoid receptor (Ki = 1.9 nM) and has much higher affinity than THC (Ki = 41 nM) for this receptor.WIN 55,212-2 reduces voluntary wheel running in laboratory mice, but with effects that depend on both genetic background and sex.WIN 55,212-2 is illegal in the UK".
- WIN_55,212-2 casNumber "131543-23-2".
- WIN_55,212-2 chEBI "73295".
- WIN_55,212-2 iupacName "(R)-(+)-[2,3-Dihydro-5-methyl-".
- WIN_55,212-2 iupacName "1-napthalenylmethanone".
- WIN_55,212-2 iupacName "3-(4-morpholinylmethyl)pyrrolo".
- WIN_55,212-2 iupacName "[1,2,3-de]-1,4-benzoxazin-6-yl]-".
- WIN_55,212-2 pubchem "5311501".
- WIN_55,212-2 thumbnail WIN_55,212-2-2D-skeletal.svg?width=300.
- WIN_55,212-2 wikiPageExternalLink win-55-212-2.
- WIN_55,212-2 wikiPageExternalLink 1904?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&fulltext=cannabinoid+alzheimer%27s&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT.
- WIN_55,212-2 wikiPageExternalLink article.ns?id=dn10330.
- WIN_55,212-2 wikiPageID "4425290".
- WIN_55,212-2 wikiPageLength "8913".
- WIN_55,212-2 wikiPageOutDegree "35".
- WIN_55,212-2 wikiPageRevisionID "705756489".
- WIN_55,212-2 wikiPageWikiLink Adenosine_triphosphate.
- WIN_55,212-2 wikiPageWikiLink Agonist.
- WIN_55,212-2 wikiPageWikiLink Alzheimers_disease.
- WIN_55,212-2 wikiPageWikiLink Aminoalkylindole.
- WIN_55,212-2 wikiPageWikiLink Amyloid_beta.
- WIN_55,212-2 wikiPageWikiLink Calcineurin.
- WIN_55,212-2 wikiPageWikiLink Cannabinoid.
- WIN_55,212-2 wikiPageWikiLink Cannabinoid_receptor.
- WIN_55,212-2 wikiPageWikiLink Cannabinoid_receptor_type_1.
- WIN_55,212-2 wikiPageWikiLink Category:Aminoalkylindoles.
- WIN_55,212-2 wikiPageWikiLink Category:CB1_receptor_agonists.
- WIN_55,212-2 wikiPageWikiLink Category:Cannabinoids.
- WIN_55,212-2 wikiPageWikiLink Category:Morpholines.
- WIN_55,212-2 wikiPageWikiLink Category:Naphthoylindoles.
- WIN_55,212-2 wikiPageWikiLink Category:WIN_compounds.
- WIN_55,212-2 wikiPageWikiLink Chemical_structure.
- WIN_55,212-2 wikiPageWikiLink Dissociation_constant.
- WIN_55,212-2 wikiPageWikiLink Genetic_marker.
- WIN_55,212-2 wikiPageWikiLink HU-210.
- WIN_55,212-2 wikiPageWikiLink JWH-133.
- WIN_55,212-2 wikiPageWikiLink JWH-200.
- WIN_55,212-2 wikiPageWikiLink MAPK1.
- WIN_55,212-2 wikiPageWikiLink MAPK3.
- WIN_55,212-2 wikiPageWikiLink Microglia.
- WIN_55,212-2 wikiPageWikiLink Mitogen-activated_protein_kinase.
- WIN_55,212-2 wikiPageWikiLink Pravadoline.
- WIN_55,212-2 wikiPageWikiLink Sperm.
- WIN_55,212-2 wikiPageWikiLink TRPV1.
- WIN_55,212-2 wikiPageWikiLink Tetrahydrocannabinol.
- WIN_55,212-2 wikiPageWikiLink WIN_54,461.
- WIN_55,212-2 wikiPageWikiLink WIN_56,098.
- WIN_55,212-2 wikiPageWikiLink File:Pancreatic_stellate_cell_cropped.png.
- WIN_55,212-2 wikiPageWikiLinkText "WIN 55,212-2".
- WIN_55,212-2 wikiPageWikiLinkText "WIN-55212-2".
- WIN_55,212-2 wikiPageWikiLinkText "WIN_55,212-2".
- WIN_55,212-2 wikiPageWikiLinkText "WIN_55,212-2#See_also".
- WIN_55,212-2 c "27".
- WIN_55,212-2 casNumber "131543".
- WIN_55,212-2 chebi "73295".
- WIN_55,212-2 chembl "188".
- WIN_55,212-2 chemspiderid "4470978".
- WIN_55,212-2 h "26".
- WIN_55,212-2 iupacName "--[2,3-Dihydro-5-methyl-".
- WIN_55,212-2 iupacName "1".
- WIN_55,212-2 iupacName "3".
- WIN_55,212-2 iupacName "[1,2,3-de]-1,4-benzoxazin-6-yl]-".
- WIN_55,212-2 iupharLigand "733".
- WIN_55,212-2 legalCa "Schedule II".
- WIN_55,212-2 molecularWeight "426.52".
- WIN_55,212-2 n "2".
- WIN_55,212-2 o "3".
- WIN_55,212-2 pubchem "5311501".
- WIN_55,212-2 smiles "CC1=CCC5=CC=CC6=CC=CC=C65".
- WIN_55,212-2 verifiedfields "changed".
- WIN_55,212-2 verifiedrevid "447554700".
- WIN_55,212-2 watchedfields "changed".
- WIN_55,212-2 width "200".
- WIN_55,212-2 wikiPageUsesTemplate Template:Cannabinoidergics.
- WIN_55,212-2 wikiPageUsesTemplate Template:Cannabinoids.
- WIN_55,212-2 wikiPageUsesTemplate Template:Cascite.
- WIN_55,212-2 wikiPageUsesTemplate Template:Chemspidercite.
- WIN_55,212-2 wikiPageUsesTemplate Template:Citation_needed.
- WIN_55,212-2 wikiPageUsesTemplate Template:Drugbox.
- WIN_55,212-2 wikiPageUsesTemplate Template:Ebicite.
- WIN_55,212-2 wikiPageUsesTemplate Template:Hallucinogens.
- WIN_55,212-2 wikiPageUsesTemplate Template:PubMed.
- WIN_55,212-2 wikiPageUsesTemplate Template:Reflist.
- WIN_55,212-2 subject Category:Aminoalkylindoles.
- WIN_55,212-2 subject Category:CB1_receptor_agonists.
- WIN_55,212-2 subject Category:Cannabinoids.
- WIN_55,212-2 subject Category:Morpholines.
- WIN_55,212-2 subject Category:Naphthoylindoles.
- WIN_55,212-2 subject Category:WIN_compounds.
- WIN_55,212-2 hypernym Chemical.
- WIN_55,212-2 type ChemicalCompound.
- WIN_55,212-2 type ChemicalSubstance.
- WIN_55,212-2 type Drug.
- WIN_55,212-2 type Cannabinoid.
- WIN_55,212-2 type Chemical.
- WIN_55,212-2 type Drug.
- WIN_55,212-2 type Ether.
- WIN_55,212-2 type Heterocycle.
- WIN_55,212-2 type Ketone.
- WIN_55,212-2 type ChemicalObject.