Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Vitamin_B12-binding_domain> ?p ?o }
Showing triples 1 to 84 of
84
with 100 triples per page.
- Vitamin_B12-binding_domain abstract "In molecular biology, the vitamin B12-binding domain is a protein domain which binds to cobalamin (vitamin B12). It can bind two different forms of the cobalamin cofactor, with cobalt bonded either to a methyl group (methylcobalamin) or to 5'-deoxyadenosine (adenosylcobalamin). Cobalamin-binding domains are mainly found in two families of enzymes present in animals and prokaryotes, which perform distinct kinds of reactions at the cobalt-carbon bond. Enzymes that require methylcobalamin carry out methyl transfer reactions. Enzymes that require adenosylcobalamin catalyse reactions in which the first step is the cleavage of adenosylcobalamin to form cob(II)alamin and the 5'-deoxyadenosyl radical, and thus act as radical generators. In both types of enzymes the B12-binding domain uses a histidine to bind the cobalt atom of cobalamin cofactors. This histidine is embedded in a DXHXXG sequence, the most conserved primary sequence motif of the domain. Proteins containing the cobalamin-binding domain include: Animal and prokaryotic methionine synthase (EC 2.1.1.13), which catalyse the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine.Animal and prokaryotic methylmalonyl-CoA mutase (EC 5.4.99.2), which are involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. Prokaryotic lysine 5,6-aminomutase (EC 5.4.3.4). Prokaryotic glutamate mutase (EC 5.4.99.1). Prokaryotic methyleneglutarate mutase (EC 5.4.99.4). Prokaryotic isobutyryl-CoA mutase (EC 5.4.99.13).The core structure of the cobalamin-binding domain is characterised by a five-stranded alpha/beta (Rossmann) fold, which consists of 5 parallel beta-sheets surrounded by 4-5 alpha helices in three layers (alpha/beta/alpha). Upon binding cobalamin, important elements of the binding site appear to become structured, including an alpha-helix that forms on one side of the cleft accommodating the nucleotide 'tail' of the cofactor. In cobalamin, the cobalt atom can be either free (dmb-off) or bound to dimethylbenzimidazole (dmb-on) according to the pH. When bound to the cobalamin-binding domain, the dimethylbenzimidazole ligand is replaced by the active histidine (His-on) of the DXHXXG motif. The replacement of dimethylbenzimidazole by histidine allows switching between the catalytic and activation cycles. In methionine synthase the cobalamin cofactor is sandwiched between the cobalamin-binding domain and an approximately 90 residues N-terminal domain forming a helical bundle comprising two pairs of antiparallel helices. This N-terminal domain forms a 4-helical bundle cap, in the conversion to the active conformation of this enzyme, the 4-helical cap rotates to allow the cobalamin cofactor to bind the activation domain.".
- Vitamin_B12-binding_domain symbol "B12-binding".
- Vitamin_B12-binding_domain symbol "B12-binding_2".
- Vitamin_B12-binding_domain thumbnail PDB_1id8_EBI.jpg?width=300.
- Vitamin_B12-binding_domain wikiPageID "32150687".
- Vitamin_B12-binding_domain wikiPageLength "6948".
- Vitamin_B12-binding_domain wikiPageOutDegree "50".
- Vitamin_B12-binding_domain wikiPageRevisionID "607873929".
- Vitamin_B12-binding_domain wikiPageWikiLink Alpha_helix.
- Vitamin_B12-binding_domain wikiPageWikiLink Animal.
- Vitamin_B12-binding_domain wikiPageWikiLink Antiparallel_(biochemistry).
- Vitamin_B12-binding_domain wikiPageWikiLink Atom.
- Vitamin_B12-binding_domain wikiPageWikiLink Base_pair.
- Vitamin_B12-binding_domain wikiPageWikiLink Beta_sheet.
- Vitamin_B12-binding_domain wikiPageWikiLink Binding_site.
- Vitamin_B12-binding_domain wikiPageWikiLink Biomolecular_structure.
- Vitamin_B12-binding_domain wikiPageWikiLink Bond_cleavage.
- Vitamin_B12-binding_domain wikiPageWikiLink Catalysis.
- Vitamin_B12-binding_domain wikiPageWikiLink Category:Protein_domains.
- Vitamin_B12-binding_domain wikiPageWikiLink Chemical_bond.
- Vitamin_B12-binding_domain wikiPageWikiLink Chemical_reaction.
- Vitamin_B12-binding_domain wikiPageWikiLink Cholesterol.
- Vitamin_B12-binding_domain wikiPageWikiLink Citric_acid_cycle.
- Vitamin_B12-binding_domain wikiPageWikiLink Cobalamin.
- Vitamin_B12-binding_domain wikiPageWikiLink Cobalt.
- Vitamin_B12-binding_domain wikiPageWikiLink Cobamamide.
- Vitamin_B12-binding_domain wikiPageWikiLink Cofactor_(biochemistry).
- Vitamin_B12-binding_domain wikiPageWikiLink Conformational_isomerism.
- Vitamin_B12-binding_domain wikiPageWikiLink Conserved_sequence.
- Vitamin_B12-binding_domain wikiPageWikiLink Dimethylbenzimidazole.
- Vitamin_B12-binding_domain wikiPageWikiLink Enzyme.
- Vitamin_B12-binding_domain wikiPageWikiLink Fatty_acid.
- Vitamin_B12-binding_domain wikiPageWikiLink Glutamate_mutase.
- Vitamin_B12-binding_domain wikiPageWikiLink Helix.
- Vitamin_B12-binding_domain wikiPageWikiLink Histidine.
- Vitamin_B12-binding_domain wikiPageWikiLink Isobutyryl-CoA_mutase.
- Vitamin_B12-binding_domain wikiPageWikiLink Ligand_(biochemistry).
- Vitamin_B12-binding_domain wikiPageWikiLink Lysine_5,6-aminomutase.
- Vitamin_B12-binding_domain wikiPageWikiLink Methionine_synthase.
- Vitamin_B12-binding_domain wikiPageWikiLink Methyl_group.
- Vitamin_B12-binding_domain wikiPageWikiLink Methyleneglutarate_mutase.
- Vitamin_B12-binding_domain wikiPageWikiLink Methylmalonyl-CoA_mutase.
- Vitamin_B12-binding_domain wikiPageWikiLink Molecular_binding.
- Vitamin_B12-binding_domain wikiPageWikiLink Nucleotide.
- Vitamin_B12-binding_domain wikiPageWikiLink Prokaryote.
- Vitamin_B12-binding_domain wikiPageWikiLink Protein.
- Vitamin_B12-binding_domain wikiPageWikiLink Protein_domain.
- Vitamin_B12-binding_domain wikiPageWikiLink Radical_(chemistry).
- Vitamin_B12-binding_domain wikiPageWikiLink Residue_(chemistry).
- Vitamin_B12-binding_domain wikiPageWikiLink Sequence_motif.
- Vitamin_B12-binding_domain wikiPageWikiLink Structural_motif.
- Vitamin_B12-binding_domain caption "how a protein binds b12: a 3.o angstrom x-ray structure of the b12-binding domains of methionine synthase".
- Vitamin_B12-binding_domain caption "nmr structure of glutamate mutase complexed with the vitamin b12 nucleotide".
- Vitamin_B12-binding_domain interpro "IPR003759".
- Vitamin_B12-binding_domain interpro "IPR006158".
- Vitamin_B12-binding_domain name "B12-binding".
- Vitamin_B12-binding_domain name "B12-binding_2".
- Vitamin_B12-binding_domain pfam "PF02310".
- Vitamin_B12-binding_domain pfam "PF02607".
- Vitamin_B12-binding_domain scop "1".
- Vitamin_B12-binding_domain symbol "B12-binding".
- Vitamin_B12-binding_domain symbol "B12-binding_2".
- Vitamin_B12-binding_domain wikiPageUsesTemplate Template:EC_number.
- Vitamin_B12-binding_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- Vitamin_B12-binding_domain wikiPageUsesTemplate Template:InterPro_content.
- Vitamin_B12-binding_domain wikiPageUsesTemplate Template:Orphan.
- Vitamin_B12-binding_domain wikiPageUsesTemplate Template:Reflist.
- Vitamin_B12-binding_domain subject Category:Protein_domains.
- Vitamin_B12-binding_domain hypernym Domain.
- Vitamin_B12-binding_domain type Biomolecule.
- Vitamin_B12-binding_domain type Protein.
- Vitamin_B12-binding_domain type Chemical.
- Vitamin_B12-binding_domain type Domain.
- Vitamin_B12-binding_domain type Thing.
- Vitamin_B12-binding_domain type Q206229.
- Vitamin_B12-binding_domain type Q8054.
- Vitamin_B12-binding_domain comment "In molecular biology, the vitamin B12-binding domain is a protein domain which binds to cobalamin (vitamin B12). It can bind two different forms of the cobalamin cofactor, with cobalt bonded either to a methyl group (methylcobalamin) or to 5'-deoxyadenosine (adenosylcobalamin). Cobalamin-binding domains are mainly found in two families of enzymes present in animals and prokaryotes, which perform distinct kinds of reactions at the cobalt-carbon bond.".
- Vitamin_B12-binding_domain label "Vitamin B12-binding domain".
- Vitamin_B12-binding_domain sameAs Q7936946.
- Vitamin_B12-binding_domain sameAs m.0gx14y1.
- Vitamin_B12-binding_domain sameAs Q7936946.
- Vitamin_B12-binding_domain wasDerivedFrom Vitamin_B12-binding_domain?oldid=607873929.
- Vitamin_B12-binding_domain depiction PDB_1id8_EBI.jpg.
- Vitamin_B12-binding_domain isPrimaryTopicOf Vitamin_B12-binding_domain.