Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/VKORC1> ?p ?o }
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- VKORC1 abstract "Vitamin K epoxide reductase complex subunit 1 is an enzyme that in humans is encoded by the VKORC1 gene.Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors. In humans and rats it has also been associated with warfarin resistance - but these mutations are rare except in Ethiopian and certain Jewish populations. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.".
- VKORC1 entrezgene "79001".
- VKORC1 wikiPageID "14756663".
- VKORC1 wikiPageLength "8130".
- VKORC1 wikiPageOutDegree "4".
- VKORC1 wikiPageRevisionID "679110038".
- VKORC1 wikiPageWikiLink Enzyme.
- VKORC1 wikiPageWikiLink Gene.
- VKORC1 wikiPageWikiLink Vitamin_K.
- VKORC1 wikiPageWikiLink Warfarin.
- VKORC1 wikiPageWikiLinkText "VKORC1".
- VKORC1 requireManualInspection "no".
- VKORC1 summaryText "Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors. In humans and rats it has also been associated with warfarin resistance - but these mutations are rare except in Ethiopian and certain Jewish populations. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.".
- VKORC1 updateCitations "yes".
- VKORC1 updatePage "yes".
- VKORC1 updateProteinBox "yes".
- VKORC1 updateSummary "yes".
- VKORC1 wikiPageUsesTemplate Template:Cite_journal.
- VKORC1 wikiPageUsesTemplate Template:Gene-16-stub.
- VKORC1 wikiPageUsesTemplate Template:PBB.
- VKORC1 wikiPageUsesTemplate Template:PBB_Controls.
- VKORC1 wikiPageUsesTemplate Template:PBB_Further_reading.
- VKORC1 wikiPageUsesTemplate Template:PBB_Summary.
- VKORC1 wikiPageUsesTemplate Template:Refbegin.
- VKORC1 wikiPageUsesTemplate Template:Refend.
- VKORC1 wikiPageUsesTemplate Template:Reflist.
- VKORC1 hypernym Enzyme.
- VKORC1 type Biomolecule.
- VKORC1 type Protein.
- VKORC1 type Thing.
- VKORC1 type Q206229.
- VKORC1 type Q8054.
- VKORC1 comment "Vitamin K epoxide reductase complex subunit 1 is an enzyme that in humans is encoded by the VKORC1 gene.Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form.".
- VKORC1 label "VKORC1".
- VKORC1 sameAs Q18045930.
- VKORC1 sameAs m.03gww6z.
- VKORC1 sameAs Q18045930.
- VKORC1 wasDerivedFrom VKORC1?oldid=679110038.
- VKORC1 isPrimaryTopicOf VKORC1.