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- Utrophin abstract "Utrophin is a protein that in humans is encoded by the UTRN gene.The protein encoded by this gene is a component of the cytoskeleton. Utrophin was found during research into Duchenne's muscular dystrophy. The name is a contraction for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6. Utrophin was discovered due to its homology with dystrophin. It was found by screening a peptide containing the C-terminal domain of dystrophin against cDNA libraries. The homology varies over its full length from less than 30% in regions of the central rod structural domain, to 85% (identity 73%) for the actin binding domain.The tertiary structure of utrophin contains a C-terminus that consists of protein–protein interaction motifs that interact with dystroglycan, a central rod region consisting of a triple coiled-coil repeat, and an actin-binding N-terminus.In normal muscle cells, utrophin is located at the neuromuscular synapse and myotendinous junctions. It is necessary for normal membrane maintenance, and for the clustering of the acetylcholine receptor. In adult humans, utrophin RNA is found ubiquitously, as the name implies, being abundant in the brain, kidney, liver, lung, muscle, spleen and stomach. In the human fetus during muscle differentiation, utrophin is found at the sarcolemma. It disappears when the fetus begins to express dystrophin.Utrophin expression is dramatically increased in patients with Duchenne's muscular dystrophy (and female carriers), both in those muscle fibers lacking dystrophin and in rare, revertant fibers that express dystrophin.No reports have yet associated mutation in the utrophin gene with disease, but it does not seem to play a critical role in development, since mice without utrophin develop normally.".
- Utrophin entrezgene "7402".
- Utrophin wikiPageID "7137936".
- Utrophin wikiPageLength "9032".
- Utrophin wikiPageOutDegree "49".
- Utrophin wikiPageRevisionID "679109820".
- Utrophin wikiPageWikiLink Acetylcholine.
- Utrophin wikiPageWikiLink Actin.
- Utrophin wikiPageWikiLink Base_pair.
- Utrophin wikiPageWikiLink Biomolecular_structure.
- Utrophin wikiPageWikiLink Brain.
- Utrophin wikiPageWikiLink C-terminus.
- Utrophin wikiPageWikiLink CDNA_library.
- Utrophin wikiPageWikiLink Category:Cell_adhesion_proteins.
- Utrophin wikiPageWikiLink Category:Cytoskeleton.
- Utrophin wikiPageWikiLink Category:Muscular_dystrophy.
- Utrophin wikiPageWikiLink Cell_membrane.
- Utrophin wikiPageWikiLink Cellular_differentiation.
- Utrophin wikiPageWikiLink Chromosome_6_(human).
- Utrophin wikiPageWikiLink Complementary_DNA.
- Utrophin wikiPageWikiLink Cytoskeleton.
- Utrophin wikiPageWikiLink Duchenne_muscular_dystrophy.
- Utrophin wikiPageWikiLink Dystroglycan.
- Utrophin wikiPageWikiLink Dystrophin.
- Utrophin wikiPageWikiLink Fetus.
- Utrophin wikiPageWikiLink Gene.
- Utrophin wikiPageWikiLink Gene_expression.
- Utrophin wikiPageWikiLink Genetic_disorder.
- Utrophin wikiPageWikiLink Homology_(biology).
- Utrophin wikiPageWikiLink Human.
- Utrophin wikiPageWikiLink Kidney.
- Utrophin wikiPageWikiLink Liver.
- Utrophin wikiPageWikiLink Lung.
- Utrophin wikiPageWikiLink Muscle.
- Utrophin wikiPageWikiLink Mutation.
- Utrophin wikiPageWikiLink Myocyte.
- Utrophin wikiPageWikiLink N-terminus.
- Utrophin wikiPageWikiLink Neuromuscular_junction.
- Utrophin wikiPageWikiLink Peptide.
- Utrophin wikiPageWikiLink Protein.
- Utrophin wikiPageWikiLink Protein_domain.
- Utrophin wikiPageWikiLink RNA.
- Utrophin wikiPageWikiLink Sarcolemma.
- Utrophin wikiPageWikiLink Spleen.
- Utrophin wikiPageWikiLink Stomach.
- Utrophin wikiPageWikiLinkText "UTRN".
- Utrophin wikiPageWikiLinkText "Utrophin".
- Utrophin wikiPageWikiLinkText "utrophin".
- Utrophin requireManualInspection "no".
- Utrophin updateCitations "yes".
- Utrophin updatePage "yes".
- Utrophin updateProteinBox "yes".
- Utrophin updateSummary "no".
- Utrophin wikiPageUsesTemplate Template:Cite_journal.
- Utrophin wikiPageUsesTemplate Template:Cytoskeletal_Proteins.
- Utrophin wikiPageUsesTemplate Template:MeshName.
- Utrophin wikiPageUsesTemplate Template:PBB.
- Utrophin wikiPageUsesTemplate Template:PBB_Controls.
- Utrophin wikiPageUsesTemplate Template:PBB_Further_reading.
- Utrophin wikiPageUsesTemplate Template:PDB_Gallery.
- Utrophin wikiPageUsesTemplate Template:Refbegin.
- Utrophin wikiPageUsesTemplate Template:Refend.
- Utrophin wikiPageUsesTemplate Template:Reflist.
- Utrophin subject Category:Cell_adhesion_proteins.
- Utrophin subject Category:Cytoskeleton.
- Utrophin subject Category:Muscular_dystrophy.
- Utrophin hypernym Protein.
- Utrophin type Biomolecule.
- Utrophin type Protein.
- Utrophin type Disorder.
- Utrophin type Thing.
- Utrophin type Q206229.
- Utrophin type Q8054.
- Utrophin comment "Utrophin is a protein that in humans is encoded by the UTRN gene.The protein encoded by this gene is a component of the cytoskeleton. Utrophin was found during research into Duchenne's muscular dystrophy. The name is a contraction for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6. Utrophin was discovered due to its homology with dystrophin.".
- Utrophin label "Utrophin".
- Utrophin sameAs Q14906152.
- Utrophin sameAs Utrophin.
- Utrophin sameAs m.0h667j.
- Utrophin sameAs Q14906152.
- Utrophin wasDerivedFrom Utrophin?oldid=679109820.
- Utrophin isPrimaryTopicOf Utrophin.