Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Ubiquitin> ?p ?o }
- Ubiquitin abstract "Ubiquitin is a small (8.5 kDa) regulatory protein that has been found in almost all tissues (ubiquitously) of eukaryotic organisms. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the 1970s and 1980s. There are four genes in the human genome that produce ubiquitin: UBB, UBC, UBA52 and RPS27A.The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitination is carried out in three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade binds ubiquitin to lysine residues on the protein substrate via an isopeptide bond, cysteine residues through a thioester bond, serine and threonine residues through an ester bond, or the amino group of the protein's N-terminus via a peptide bond.The protein modifications can be either a single ubiquitin protein (monoubiquitination) or a chain of ubiquitin (polyubiquitination). The ubiquitination bonds are always formed with one of the seven lysine residues from the ubiquitin molecule. These 'linking' lysines are represented by a \"K\" (which is the one-letter amino acid notation of lysine) and a number, referring to its position in the ubiquitin molecule. First, a ubiquitin molecule is bonded by its C-terminus to a specific lysine residue (e.g. K48, K29, K63,...) on the target protein. Poly-ubiquitination occurs when the C-terminus of another ubiquitin, will be linked again to a lysine residue (for example again K48 or K29) on the previously added ubiquitin molecule, forming a chain. This process repeats several times, leading to the addition of several ubiquitins. Only poly-ubiquitination on defined lysines, mostly on K48 and K29, is related to degradation with the proteasome (referred to as the \"molecular kiss of death\"), while other polyubiquitinations (e.g. on K63, K11, K6) and monoubiquitinations may regulate processes such as endocytic trafficking, inflammation, translation and DNA repair.Lysine 48-linked chains have been much-studied. They are the forms of chains that signal proteins to the proteasome, which destroys and recycles proteins. This discovery won the Nobel Prize for chemistry in 2004.".
- Ubiquitin symbol "ubiquitin".
- Ubiquitin thumbnail Ubiquitin_cartoon-2-.png?width=300.
- Ubiquitin wikiPageExternalLink 7-340-ubiquitination-the-proteasome-and-human-disease-fall-2004.
- Ubiquitin wikiPageExternalLink uniProtView.do?proteinAc=P62988.
- Ubiquitin wikiPageExternalLink NBK1144.
- Ubiquitin wikiPageExternalLink 105830,601623,105830,601623.
- Ubiquitin wikiPageID "32167".
- Ubiquitin wikiPageLength "67867".
- Ubiquitin wikiPageOutDegree "281".
- Ubiquitin wikiPageRevisionID "704815907".
- Ubiquitin wikiPageWikiLink 3-M_syndrome.
- Ubiquitin wikiPageWikiLink ANUBL1.
- Ubiquitin wikiPageWikiLink ATG12.
- Ubiquitin wikiPageWikiLink ATG8.
- Ubiquitin wikiPageWikiLink Aaron_Ciechanover.
- Ubiquitin wikiPageWikiLink Active_site.
- Ubiquitin wikiPageWikiLink Adenosine_monophosphate.
- Ubiquitin wikiPageWikiLink Adenosine_triphosphate.
- Ubiquitin wikiPageWikiLink Alcoholic_liver_disease.
- Ubiquitin wikiPageWikiLink Alzheimers_disease.
- Ubiquitin wikiPageWikiLink Amine.
- Ubiquitin wikiPageWikiLink Amino_acid.
- Ubiquitin wikiPageWikiLink Amyloid_precursor_protein.
- Ubiquitin wikiPageWikiLink Anaphase-promoting_complex.
- Ubiquitin wikiPageWikiLink Angelman_syndrome.
- Ubiquitin wikiPageWikiLink Antibody.
- Ubiquitin wikiPageWikiLink Antigen_processing.
- Ubiquitin wikiPageWikiLink Apoptosis.
- Ubiquitin wikiPageWikiLink Astrocyte.
- Ubiquitin wikiPageWikiLink Atomic_mass_unit.
- Ubiquitin wikiPageWikiLink Autophagin.
- Ubiquitin wikiPageWikiLink Autophagy.
- Ubiquitin wikiPageWikiLink Avram_Hershko.
- Ubiquitin wikiPageWikiLink BAG1.
- Ubiquitin wikiPageWikiLink BRCA1.
- Ubiquitin wikiPageWikiLink Biogenesis.
- Ubiquitin wikiPageWikiLink Biological_membrane.
- Ubiquitin wikiPageWikiLink C-terminus.
- Ubiquitin wikiPageWikiLink C1orf131.
- Ubiquitin wikiPageWikiLink CUL7.
- Ubiquitin wikiPageWikiLink Carboxylic_acid.
- Ubiquitin wikiPageWikiLink Category:Posttranslational_modification.
- Ubiquitin wikiPageWikiLink Category:Protein_structure.
- Ubiquitin wikiPageWikiLink Category:Proteins.
- Ubiquitin wikiPageWikiLink Cell_(biology).
- Ubiquitin wikiPageWikiLink Cysteine.
- Ubiquitin wikiPageWikiLink Cysteine_protease.
- Ubiquitin wikiPageWikiLink DDI1.
- Ubiquitin wikiPageWikiLink DDI2.
- Ubiquitin wikiPageWikiLink DNA.
- Ubiquitin wikiPageWikiLink DNA_repair.
- Ubiquitin wikiPageWikiLink DNA_synthesis.
- Ubiquitin wikiPageWikiLink Deubiquitinating_enzyme.
- Ubiquitin wikiPageWikiLink ESCRT.
- Ubiquitin wikiPageWikiLink Endocytosis.
- Ubiquitin wikiPageWikiLink Endoplasmic-reticulum-associated_protein_degradation.
- Ubiquitin wikiPageWikiLink Ester.
- Ubiquitin wikiPageWikiLink Eukaryote.
- Ubiquitin wikiPageWikiLink FAU_(gene).
- Ubiquitin wikiPageWikiLink Fanconi_anemia.
- Ubiquitin wikiPageWikiLink Genetic_disorder.
- Ubiquitin wikiPageWikiLink Glycine.
- Ubiquitin wikiPageWikiLink H2AFX.
- Ubiquitin wikiPageWikiLink HECT_domain.
- Ubiquitin wikiPageWikiLink HERPUD1.
- Ubiquitin wikiPageWikiLink HERPUD2.
- Ubiquitin wikiPageWikiLink HLA-B_associated_transcript_3.
- Ubiquitin wikiPageWikiLink HOPS.
- Ubiquitin wikiPageWikiLink Histone.
- Ubiquitin wikiPageWikiLink Human_genome.
- Ubiquitin wikiPageWikiLink Huntingtons_disease.
- Ubiquitin wikiPageWikiLink Hydroxyl.
- Ubiquitin wikiPageWikiLink IKK2.
- Ubiquitin wikiPageWikiLink ISG15.
- Ubiquitin wikiPageWikiLink Immunohistochemistry.
- Ubiquitin wikiPageWikiLink Inclusion_bodies.
- Ubiquitin wikiPageWikiLink Inflammation.
- Ubiquitin wikiPageWikiLink Irwin_Rose.
- Ubiquitin wikiPageWikiLink Isoelectric_point.
- Ubiquitin wikiPageWikiLink Isopeptide_bond.
- Ubiquitin wikiPageWikiLink JUNQ_and_IPOD.
- Ubiquitin wikiPageWikiLink LOC391257.
- Ubiquitin wikiPageWikiLink Lewy_body.
- Ubiquitin wikiPageWikiLink Lysine.
- Ubiquitin wikiPageWikiLink Lysosome.
- Ubiquitin wikiPageWikiLink Lysozyme.
- Ubiquitin wikiPageWikiLink Magnesium.
- Ubiquitin wikiPageWikiLink Mallory_body.
- Ubiquitin wikiPageWikiLink Mdm2.
- Ubiquitin wikiPageWikiLink Midshipman.
- Ubiquitin wikiPageWikiLink MoaD.
- Ubiquitin wikiPageWikiLink Molecular_mass.
- Ubiquitin wikiPageWikiLink Molybdenum_cofactor.
- Ubiquitin wikiPageWikiLink Motor_neuron_disease.
- Ubiquitin wikiPageWikiLink MyoD.
- Ubiquitin wikiPageWikiLink N-terminus.
- Ubiquitin wikiPageWikiLink NEDD8.
- Ubiquitin wikiPageWikiLink Neurodegeneration.
- Ubiquitin wikiPageWikiLink Neurofibrillary_tangle.