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- USP4 abstract "Ubiquitin specific protease 4 (USP4) is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein is encoded by a gene containing 22 exons.This protein is a member of cysteine peptidase family C19. As a deubiquitinating enzyme it is unusual in having the capacity to cleave ubiquitin-proline bonds. This property may reflect structural flexibility in the active site of the enzyme, and may explain its ability to cleave ubiquitin chains of various linkages. USP4 has substrates of important function in a number of cell signalling pathways, including the NF-κB, TGF-β, Wnt/β-catenin, p53, and spliceosome pathways. Other substrates include the adenosine A2A receptor and the Ro52 (TRIM21) protein.".
- USP4 entrezgene "7375".
- USP4 wikiPageID "14878638".
- USP4 wikiPageLength "7647".
- USP4 wikiPageOutDegree "15".
- USP4 wikiPageRevisionID "674801726".
- USP4 wikiPageWikiLink Adenosine_A2A_receptor.
- USP4 wikiPageWikiLink Cysteine_protease.
- USP4 wikiPageWikiLink Deubiquitinating_enzyme.
- USP4 wikiPageWikiLink Enzyme.
- USP4 wikiPageWikiLink Exon.
- USP4 wikiPageWikiLink NF-κB.
- USP4 wikiPageWikiLink P53.
- USP4 wikiPageWikiLink Proline.
- USP4 wikiPageWikiLink Protein–protein_interaction.
- USP4 wikiPageWikiLink Retinoblastoma_protein.
- USP4 wikiPageWikiLink Spliceosome.
- USP4 wikiPageWikiLink TRIM21.
- USP4 wikiPageWikiLink Transforming_growth_factor_beta.
- USP4 wikiPageWikiLink Ubiquitin.
- USP4 wikiPageWikiLink Wnt_signaling_pathway.
- USP4 wikiPageWikiLinkText "USP4".
- USP4 wikiPageUsesTemplate Template:Cite_journal.
- USP4 wikiPageUsesTemplate Template:Gene-3-stub.
- USP4 wikiPageUsesTemplate Template:PBB.
- USP4 wikiPageUsesTemplate Template:Refbegin.
- USP4 wikiPageUsesTemplate Template:Refend.
- USP4 wikiPageUsesTemplate Template:Reflist.
- USP4 hypernym Enzyme.
- USP4 type Biomolecule.
- USP4 type Protein.
- USP4 type Thing.
- USP4 type Q206229.
- USP4 type Q8054.
- USP4 comment "Ubiquitin specific protease 4 (USP4) is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein is encoded by a gene containing 22 exons.This protein is a member of cysteine peptidase family C19. As a deubiquitinating enzyme it is unusual in having the capacity to cleave ubiquitin-proline bonds.".
- USP4 label "USP4".
- USP4 sameAs Q18032291.
- USP4 sameAs USP4.
- USP4 sameAs m.03h012s.
- USP4 sameAs Q18032291.
- USP4 wasDerivedFrom USP4?oldid=674801726.
- USP4 isPrimaryTopicOf USP4.