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- Trifunctional_antibody abstract "A trifunctional antibody is a monoclonal antibody with binding sites for two different antigens, typically CD3 and a tumor antigen, making it a type of bispecific monoclonal antibody. In addition, its intact Fc-part can bind to an Fc receptor on accessory cells like conventional monospecific antibodies. The net effect is that this type of drug links T cells (via CD3) and monocytes/macrophages, natural killer cells, dendritic cells or other Fc receptor expressing cells to the tumor cells, leading to their destruction.At an equivalent dose a trifunctional antibody is more potent (more than 1,000-fold) in eliminating tumor cells than conventional antibodies. These drugs evoke the removal of tumor cells by means of (i) antibody-dependent cell-mediated cytoxicity, a process also described for conventional antibodies and more importantly by (ii) polyclonal cytotoxic T cell responses with emphasis on CD8 T cells. These trifunctional antibodies also elicit individual anti-tumor immune responses in cancer patients treated with e.g. catumaxomab; i.e. autologous antibodies as well as CD4 and CD8 T cells directed against the tumor were detected. Furthermore, putative cancer stem cells from malignant ascites fluid were eliminated due to catumaxomab treatment.Examples include catumaxomab (EpCAM / CD3), ertumaxomab (HER2/neu / CD3), FBTA05 (CD20 / CD3, proposed trade name Lymphomun) and TRBS07 (GD2 / CD3, proposed trade name Ektomab), drugs against various types of cancer.".
- Trifunctional_antibody thumbnail Catumaxomab_mechanism.svg?width=300.
- Trifunctional_antibody wikiPageID "25092134".
- Trifunctional_antibody wikiPageLength "13225".
- Trifunctional_antibody wikiPageOutDegree "34".
- Trifunctional_antibody wikiPageRevisionID "704884978".
- Trifunctional_antibody wikiPageWikiLink Antibody-dependent_cell-mediated_cytotoxicity.
- Trifunctional_antibody wikiPageWikiLink Antigen-presenting_cell.
- Trifunctional_antibody wikiPageWikiLink Ascites.
- Trifunctional_antibody wikiPageWikiLink Bi-specific_T-cell_engager.
- Trifunctional_antibody wikiPageWikiLink Bispecific_monoclonal_antibody.
- Trifunctional_antibody wikiPageWikiLink CD20.
- Trifunctional_antibody wikiPageWikiLink CD3_(immunology).
- Trifunctional_antibody wikiPageWikiLink Cancer_stem_cell.
- Trifunctional_antibody wikiPageWikiLink Category:Immunology.
- Trifunctional_antibody wikiPageWikiLink Category:Monoclonal_antibodies.
- Trifunctional_antibody wikiPageWikiLink Catumaxomab.
- Trifunctional_antibody wikiPageWikiLink Chromatography.
- Trifunctional_antibody wikiPageWikiLink Cytokine.
- Trifunctional_antibody wikiPageWikiLink Cytotoxic_T_cell.
- Trifunctional_antibody wikiPageWikiLink Dendritic_cell.
- Trifunctional_antibody wikiPageWikiLink Epithelial_cell_adhesion_molecule.
- Trifunctional_antibody wikiPageWikiLink Ertumaxomab.
- Trifunctional_antibody wikiPageWikiLink Fc_receptor.
- Trifunctional_antibody wikiPageWikiLink GD2.
- Trifunctional_antibody wikiPageWikiLink neu.
- Trifunctional_antibody wikiPageWikiLink Hybridoma_technology.
- Trifunctional_antibody wikiPageWikiLink Immunoglobulin_heavy_chain.
- Trifunctional_antibody wikiPageWikiLink Immunoglobulin_light_chain.
- Trifunctional_antibody wikiPageWikiLink Macrophage.
- Trifunctional_antibody wikiPageWikiLink Monoclonal_antibody.
- Trifunctional_antibody wikiPageWikiLink Monocyte.
- Trifunctional_antibody wikiPageWikiLink Natural_killer_cell.
- Trifunctional_antibody wikiPageWikiLink Nausea.
- Trifunctional_antibody wikiPageWikiLink Protein_A.
- Trifunctional_antibody wikiPageWikiLink T_cell.
- Trifunctional_antibody wikiPageWikiLink Tumor_antigen.
- Trifunctional_antibody wikiPageWikiLink File:Catumaxomab_mechanism.svg.
- Trifunctional_antibody wikiPageWikiLink File:Quadroma_antibodies.svg.
- Trifunctional_antibody wikiPageWikiLinkText "Trifunctional antibody".
- Trifunctional_antibody wikiPageWikiLinkText "Trifunctional antibody#Production".
- Trifunctional_antibody wikiPageWikiLinkText "trifunctional antibody".
- Trifunctional_antibody wikiPageUsesTemplate Template:Cite_journal.
- Trifunctional_antibody wikiPageUsesTemplate Template:Engineered_antibodies.
- Trifunctional_antibody wikiPageUsesTemplate Template:Monoclonals_for_tumors.
- Trifunctional_antibody wikiPageUsesTemplate Template:Reflist.
- Trifunctional_antibody subject Category:Immunology.
- Trifunctional_antibody subject Category:Monoclonal_antibodies.
- Trifunctional_antibody hypernym Antibody.
- Trifunctional_antibody type Drug.
- Trifunctional_antibody type Antibody.
- Trifunctional_antibody type Redirect.
- Trifunctional_antibody comment "A trifunctional antibody is a monoclonal antibody with binding sites for two different antigens, typically CD3 and a tumor antigen, making it a type of bispecific monoclonal antibody. In addition, its intact Fc-part can bind to an Fc receptor on accessory cells like conventional monospecific antibodies.".
- Trifunctional_antibody label "Trifunctional antibody".
- Trifunctional_antibody sameAs Q7841565.
- Trifunctional_antibody sameAs m.09g7t_h.
- Trifunctional_antibody sameAs Q7841565.
- Trifunctional_antibody wasDerivedFrom Trifunctional_antibody?oldid=704884978.
- Trifunctional_antibody depiction Catumaxomab_mechanism.svg.
- Trifunctional_antibody isPrimaryTopicOf Trifunctional_antibody.