Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Transforming_growth_factor_beta> ?p ?o }
- Transforming_growth_factor_beta abstract "Transforming growth factor beta (TGF-β) is a pleiotropic cytokine belonging to the TGF-beta superfamily that includes three different isoforms (TGF-beta 1-3) and many other signaling proteins produced by all white blood cell lineages. Activated TGF-beta complexes with other factors to form a serine/threonine kinase that activates a signaling cascade that leads to the transcription of its many target genes, functioning in differentiation, chemotaxis, proliferation, and activation of many immune cells.TGF-β is secreted by many cell types, including macrophages, in a latent form in which it is complexed with two other polypeptides, latent TGF-beta binding protein (LTBP) and latency-associated peptide (LAP). Serum proteinases such as plasmin catalyze the release of active TGF-β from the complex. This often occurs on the surface of macrophages where the latent TGF-β complex is bound to CD36 via its ligand, thrombospondin-1 (TSP-1). Inflammatory stimuli that activate macrophages enhance the release of active TGF-β by promoting the activation of plasmin. Macrophages can also endocytose IgG-bound latent TGF-β complexes that are secreted by plasma cells and then release active TGF-β into the extracellular fluid. Among its key functions is regulation of inflammatory processes, particularly in the gut. TGF-beta also plays a crucial role in stem cell differentiation as well as T-cell regulation and differentiation. As such, it is a highly researched cytokine in the fields of cancer, auto-immune diseases, and infectious disease.The TGF-beta superfamily includes endogenous growth inhibiting proteins; an increase in expression of TGF-beta oftens correlates with the malignancy of many cancers and a defect in the cellular growth inhibition response to TGF-beta. Its immuno-suppressive functions then come to dominate, contributing to oncogenesis. The disregulation of its immunosuppressive functions is also implicated in the pathogenesis of autoimmune diseases, although their effect is mediated by the environment of other cytokines present.".
- Transforming_growth_factor_beta wikiPageExternalLink do_annotation.pl?DOMAIN=TGFB.
- Transforming_growth_factor_beta wikiPageExternalLink get_pathway?org_name=hsa&mapno=04350.
- Transforming_growth_factor_beta wikiPageExternalLink TGF_system.
- Transforming_growth_factor_beta wikiPageExternalLink query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7040.
- Transforming_growth_factor_beta wikiPageExternalLink tgfbetapathway.html.
- Transforming_growth_factor_beta wikiPageExternalLink 080223122241.htm.
- Transforming_growth_factor_beta wikiPageExternalLink elisa-analysis-latent-tgf-%CE%B21.
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- Transforming_growth_factor_beta wikiPageRevisionID "708197831".
- Transforming_growth_factor_beta wikiPageWikiLink Alzheimers_disease.
- Transforming_growth_factor_beta wikiPageWikiLink Amino_acid.
- Transforming_growth_factor_beta wikiPageWikiLink Anita_Roberts.
- Transforming_growth_factor_beta wikiPageWikiLink Aortic_dissection.
- Transforming_growth_factor_beta wikiPageWikiLink Apoptosis.
- Transforming_growth_factor_beta wikiPageWikiLink Arachnodactyly.
- Transforming_growth_factor_beta wikiPageWikiLink Atherosclerosis.
- Transforming_growth_factor_beta wikiPageWikiLink C-Jun_N-terminal_kinases.
- Transforming_growth_factor_beta wikiPageWikiLink C-terminus.
- Transforming_growth_factor_beta wikiPageWikiLink CD36.
- Transforming_growth_factor_beta wikiPageWikiLink Cardiovascular_disease.
- Transforming_growth_factor_beta wikiPageWikiLink Category:TGFβ_domain.
- Transforming_growth_factor_beta wikiPageWikiLink Cell_cycle.
- Transforming_growth_factor_beta wikiPageWikiLink Cell_nucleus.
- Transforming_growth_factor_beta wikiPageWikiLink Cholesterol.
- Transforming_growth_factor_beta wikiPageWikiLink Cysteine.
- Transforming_growth_factor_beta wikiPageWikiLink Cystine_knot.
- Transforming_growth_factor_beta wikiPageWikiLink Death-associated_protein_6.
- Transforming_growth_factor_beta wikiPageWikiLink Diabetic_nephropathy.
- Transforming_growth_factor_beta wikiPageWikiLink Disulfide.
- Transforming_growth_factor_beta wikiPageWikiLink Ectopia_lentis.
- Transforming_growth_factor_beta wikiPageWikiLink Elastic_fiber.
- Transforming_growth_factor_beta wikiPageWikiLink Endometrium.
- Transforming_growth_factor_beta wikiPageWikiLink European_Molecular_Biology_Laboratory.
- Transforming_growth_factor_beta wikiPageWikiLink Experimental_autoimmune_encephalomyelitis.
- Transforming_growth_factor_beta wikiPageWikiLink Extracellular_matrix.
- Transforming_growth_factor_beta wikiPageWikiLink FOXP3.
- Transforming_growth_factor_beta wikiPageWikiLink Fibrillin.
- Transforming_growth_factor_beta wikiPageWikiLink G1_Phase.
- Transforming_growth_factor_beta wikiPageWikiLink G1_phase.
- Transforming_growth_factor_beta wikiPageWikiLink Glycoprotein.
- Transforming_growth_factor_beta wikiPageWikiLink Immune_tolerance.
- Transforming_growth_factor_beta wikiPageWikiLink Immunoglobulin_A.
- Transforming_growth_factor_beta wikiPageWikiLink Interleukin_10.
- Transforming_growth_factor_beta wikiPageWikiLink Interleukin_2.
- Transforming_growth_factor_beta wikiPageWikiLink Keratoconus.
- Transforming_growth_factor_beta wikiPageWikiLink Latency_associated_peptide.
- Transforming_growth_factor_beta wikiPageWikiLink Latent_TGF-beta_binding_protein.
- Transforming_growth_factor_beta wikiPageWikiLink Lefty_(protein).
- Transforming_growth_factor_beta wikiPageWikiLink Loeys–Dietz_syndrome.
- Transforming_growth_factor_beta wikiPageWikiLink MMP2.
- Transforming_growth_factor_beta wikiPageWikiLink MMP9.
- Transforming_growth_factor_beta wikiPageWikiLink Marfan_syndrome.
- Transforming_growth_factor_beta wikiPageWikiLink Matrix_metalloproteinase.
- Transforming_growth_factor_beta wikiPageWikiLink Menstruation.
- Transforming_growth_factor_beta wikiPageWikiLink Mitogen-activated_protein_kinase.
- Transforming_growth_factor_beta wikiPageWikiLink Mitral_valve_prolapse.
- Transforming_growth_factor_beta wikiPageWikiLink Mothers_against_decapentaplegic_homolog_4.
- Transforming_growth_factor_beta wikiPageWikiLink Multiple_sclerosis.
- Transforming_growth_factor_beta wikiPageWikiLink Myc.
- Transforming_growth_factor_beta wikiPageWikiLink Myelin.
- Transforming_growth_factor_beta wikiPageWikiLink Plasmin.
- Transforming_growth_factor_beta wikiPageWikiLink Protease.
- Transforming_growth_factor_beta wikiPageWikiLink Protein_precursor.
- Transforming_growth_factor_beta wikiPageWikiLink Proteolysis.
- Transforming_growth_factor_beta wikiPageWikiLink R-SMAD.
- Transforming_growth_factor_beta wikiPageWikiLink Regulatory_T_cell.
- Transforming_growth_factor_beta wikiPageWikiLink Retinoblastoma_protein.
- Transforming_growth_factor_beta wikiPageWikiLink STAT3.
- Transforming_growth_factor_beta wikiPageWikiLink Signal_peptide.
- Transforming_growth_factor_beta wikiPageWikiLink Simple_Modular_Architecture_Research_Tool.
- Transforming_growth_factor_beta wikiPageWikiLink Statin.
- Transforming_growth_factor_beta wikiPageWikiLink TGF_beta_1.
- Transforming_growth_factor_beta wikiPageWikiLink TGF_beta_2.
- Transforming_growth_factor_beta wikiPageWikiLink TGF_beta_signaling_pathway.
- Transforming_growth_factor_beta wikiPageWikiLink T_helper_17_cell.
- Transforming_growth_factor_beta wikiPageWikiLink Thrombospondin_1.
- Transforming_growth_factor_beta wikiPageWikiLink Transforming_growth_factor.
- Transforming_growth_factor_beta wikiPageWikiLink Transforming_growth_factor,_beta_3.
- Transforming_growth_factor_beta wikiPageWikiLink File:DAXX_Pathway.svg.
- Transforming_growth_factor_beta wikiPageWikiLink File:SMAD_apoptosis.svg.
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF beta".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF-beta pathway".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF-beta".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF-ß1".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF-β ligand".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF-β superfamily".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGF-β".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGFβ".
- Transforming_growth_factor_beta wikiPageWikiLinkText "TGFβs".
- Transforming_growth_factor_beta wikiPageWikiLinkText "Transforming growth factor beta".
- Transforming_growth_factor_beta wikiPageWikiLinkText "transforming growth factor TGF-β".
- Transforming_growth_factor_beta wikiPageWikiLinkText "transforming growth factor beta".
- Transforming_growth_factor_beta wikiPageWikiLinkText "transforming growth factor β".
- Transforming_growth_factor_beta wikiPageWikiLinkText "transforming growth factor-beta".
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- Transforming_growth_factor_beta wikiPageUsesTemplate Template:MeshName.
- Transforming_growth_factor_beta wikiPageUsesTemplate Template:OMIM.