Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Tetraspanin> ?p ?o }
- Tetraspanin abstract "Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N- and C-termini and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2). Although several protein families have four transmembrane domains, tetraspanins are defined by conserved domains listed in the Protein Families database under pfam00335.12. The key features are four or more cysteine residues in the EC2 domain, with two in a highly conserved 'CCG' motif.Research into this field is relatively recent (less than 20 years) and therefore there is much to learn about the function of specific tetraspanins. Generally, tetraspanins are often thought to act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane.Tetraspanins are highly conserved between species. Some tetraspanins can have N-linked glycosylations on the long extracellular loop (LEL, EC2) and palmitoylations at a CXXC motif in their transmembrane region.There are 34 tetraspanins in mammals, 33 of which have also been identified in humans. Tetraspanins display numerous properties that indicate their physiological importance in cell adhesion, motility, activation and proliferation, as well as their contribution to pathological conditions such as metastasis or viral infection.A role for tetraspanins in platelets was demonstrated by the bleeding phenotypes of CD151- and TSSC6-deficient mice, which exhibit impaired \"outside-in\" signalling through αIIbβ3, the major platelet integrin. it is hypothesized that tetraspanins interact with and regulate other platelet receptors.".
- Tetraspanin symbol "Tetraspanin".
- Tetraspanin thumbnail Tetraspanin_Figure.jpg?width=300.
- Tetraspanin wikiPageExternalLink IEntry?ac=IPR008952.
- Tetraspanin wikiPageExternalLink Tetraspanin-table.doc.
- Tetraspanin wikiPageID "5917545".
- Tetraspanin wikiPageLength "6010".
- Tetraspanin wikiPageOutDegree "64".
- Tetraspanin wikiPageRevisionID "593854159".
- Tetraspanin wikiPageWikiLink C-terminus.
- Tetraspanin wikiPageWikiLink CD151.
- Tetraspanin wikiPageWikiLink CD37.
- Tetraspanin wikiPageWikiLink CD53.
- Tetraspanin wikiPageWikiLink CD63.
- Tetraspanin wikiPageWikiLink CD81.
- Tetraspanin wikiPageWikiLink CD82_(gene).
- Tetraspanin wikiPageWikiLink CD9.
- Tetraspanin wikiPageWikiLink Category:Immunology.
- Tetraspanin wikiPageWikiLink Category:Integral_membrane_proteins.
- Tetraspanin wikiPageWikiLink Category:Membrane_biology.
- Tetraspanin wikiPageWikiLink Category:Protein_domains.
- Tetraspanin wikiPageWikiLink Cell_growth.
- Tetraspanin wikiPageWikiLink Conserved_sequence.
- Tetraspanin wikiPageWikiLink Cysteine.
- Tetraspanin wikiPageWikiLink Eukaryote.
- Tetraspanin wikiPageWikiLink IIIa.
- Tetraspanin wikiPageWikiLink Glycosylation.
- Tetraspanin wikiPageWikiLink List_of_human_clusters_of_differentiation.
- Tetraspanin wikiPageWikiLink Membrane_protein.
- Tetraspanin wikiPageWikiLink Metastasis.
- Tetraspanin wikiPageWikiLink Multicellular_organism.
- Tetraspanin wikiPageWikiLink N-terminus.
- Tetraspanin wikiPageWikiLink Palmitoylation.
- Tetraspanin wikiPageWikiLink Peripherin_2.
- Tetraspanin wikiPageWikiLink Pfam.
- Tetraspanin wikiPageWikiLink Platelet.
- Tetraspanin wikiPageWikiLink Schistosoma.
- Tetraspanin wikiPageWikiLink Schistosomiasis.
- Tetraspanin wikiPageWikiLink TSPAN1.
- Tetraspanin wikiPageWikiLink TSPAN10.
- Tetraspanin wikiPageWikiLink TSPAN11.
- Tetraspanin wikiPageWikiLink TSPAN12.
- Tetraspanin wikiPageWikiLink TSPAN13.
- Tetraspanin wikiPageWikiLink TSPAN14.
- Tetraspanin wikiPageWikiLink TSPAN15.
- Tetraspanin wikiPageWikiLink TSPAN16.
- Tetraspanin wikiPageWikiLink TSPAN17.
- Tetraspanin wikiPageWikiLink TSPAN18.
- Tetraspanin wikiPageWikiLink TSPAN19.
- Tetraspanin wikiPageWikiLink TSPAN2.
- Tetraspanin wikiPageWikiLink TSPAN21.
- Tetraspanin wikiPageWikiLink TSPAN23.
- Tetraspanin wikiPageWikiLink TSPAN3.
- Tetraspanin wikiPageWikiLink TSPAN31.
- Tetraspanin wikiPageWikiLink TSPAN32.
- Tetraspanin wikiPageWikiLink TSPAN33.
- Tetraspanin wikiPageWikiLink TSPAN34.
- Tetraspanin wikiPageWikiLink TSPAN4.
- Tetraspanin wikiPageWikiLink TSPAN5.
- Tetraspanin wikiPageWikiLink TSPAN6.
- Tetraspanin wikiPageWikiLink TSPAN7.
- Tetraspanin wikiPageWikiLink TSPAN8.
- Tetraspanin wikiPageWikiLink TSPAN9.
- Tetraspanin wikiPageWikiLink UPK1B.
- Tetraspanin wikiPageWikiLinkText "Tetraspanin".
- Tetraspanin wikiPageWikiLinkText "tetraspanin".
- Tetraspanin caption "Tetraspanins have four transmembrane domains, two extracellular loops and contain a series of highly conserved amino acid residues.".
- Tetraspanin cdd "cd03127".
- Tetraspanin interpro "IPR000301".
- Tetraspanin name "Tetraspanin family".
- Tetraspanin pdb ",".
- Tetraspanin pfam "PF00335".
- Tetraspanin pfamClan "CL0347".
- Tetraspanin prosite "PDOC00371".
- Tetraspanin scop "1".
- Tetraspanin symbol "Tetraspanin".
- Tetraspanin width "250".
- Tetraspanin wikiPageUsesTemplate Template:Gene.
- Tetraspanin wikiPageUsesTemplate Template:Membrane_proteins.
- Tetraspanin wikiPageUsesTemplate Template:PDB3.
- Tetraspanin wikiPageUsesTemplate Template:Pfam_box.
- Tetraspanin wikiPageUsesTemplate Template:Reflist.
- Tetraspanin subject Category:Immunology.
- Tetraspanin subject Category:Integral_membrane_proteins.
- Tetraspanin subject Category:Membrane_biology.
- Tetraspanin subject Category:Protein_domains.
- Tetraspanin hypernym Family.
- Tetraspanin type Biomolecule.
- Tetraspanin type Protein.
- Tetraspanin type Biophysic.
- Tetraspanin type Chemical.
- Tetraspanin type Domain.
- Tetraspanin type Redirect.
- Tetraspanin type Specialty.
- Tetraspanin type Thing.
- Tetraspanin type Q206229.
- Tetraspanin type Q8054.
- Tetraspanin comment "Tetraspanins are a family of membrane proteins found in all multicellular eukaryotes.Tetraspanins, also called tetraspans or the transmembrane 4 superfamily (TM4SF), have four transmembrane domains, intracellular N- and C-termini and two extracellular domains, one short (called the small extracellular domain or loop, SED/SEL or EC1) and one longer, typically 100 amino acid residues (the large extracellular domain/loop, LED/LEL or EC2).".
- Tetraspanin label "Tetraspanin".
- Tetraspanin sameAs Q7706740.