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- Termination_factor abstract "Termination is part of the process of transcribing RNA. In eukaryotes, a termination factor is required to release the newly made (nascent) RNA from the transcription complex. Prokaryote mRNAs often do not require a termination factor: an inverted repeat followed by a string of Us (uracils) in the mRNA template strand forms a stem-loop structure which destabilizes binding by the RNA polymerase and causes Rho-independent transcription termination.The most extensively studied transcriptional termination factor is the Rho protein of E. coli. The Rho protein recognizes a cytosine-rich region of the elongating mRNA, but the exact features of the recognized sequences remain unknown. Rho forms a ring-shaped hexamer and advances along the mRNA, hydrolyzing ATP, toward RNA polymerase (5' to 3' with respect to the mRNA). When the Rho protein reaches the RNA polymerase complex, transcription is terminated by dissociation of the RNA polymerase from the DNA. The structure, as well as the activity, of the Rho protein is similar to that of the F1 subunit of ATP synthase, supporting the theory that the two share an evolutionary link. The antibiotic bicyclomycin works by inhibiting Rho.The process of transcriptional termination is less well understood in eukaryotes, which have extensive post-transcriptional RNA processing. Each of the three types of eukaryotic RNA polymerase has a different termination system. Eukaryotic termination factors bind to the termination signal region and disturb RNA polymerase II as it moves by, causing it to fall off the DNA strand within the next 300 base pairs. This 300 bp region is removed during processing, before poly(A)tailing (see Polyadenylation).".
- Termination_factor wikiPageID "2824875".
- Termination_factor wikiPageLength "2842".
- Termination_factor wikiPageOutDegree "22".
- Termination_factor wikiPageRevisionID "695887274".
- Termination_factor wikiPageWikiLink ATP_synthase.
- Termination_factor wikiPageWikiLink Adenosine_triphosphate.
- Termination_factor wikiPageWikiLink Bicyclomycin.
- Termination_factor wikiPageWikiLink Category:Gene_expression.
- Termination_factor wikiPageWikiLink Category:Molecular_genetics.
- Termination_factor wikiPageWikiLink Cytosine.
- Termination_factor wikiPageWikiLink DNA.
- Termination_factor wikiPageWikiLink Escherichia_coli.
- Termination_factor wikiPageWikiLink Eukaryote.
- Termination_factor wikiPageWikiLink Intrinsic_termination.
- Termination_factor wikiPageWikiLink Inverted_repeat.
- Termination_factor wikiPageWikiLink Messenger_RNA.
- Termination_factor wikiPageWikiLink Polyadenylation.
- Termination_factor wikiPageWikiLink Prokaryote.
- Termination_factor wikiPageWikiLink RNA.
- Termination_factor wikiPageWikiLink RNA_polymerase.
- Termination_factor wikiPageWikiLink RNA_polymerase_II.
- Termination_factor wikiPageWikiLink Termination_signal.
- Termination_factor wikiPageWikiLink Transcription_complex.
- Termination_factor wikiPageWikiLink Uracil.
- Termination_factor wikiPageWikiLinkText "Termination factor".
- Termination_factor wikiPageWikiLinkText "termination factor".
- Termination_factor wikiPageWikiLinkText "termination".
- Termination_factor wikiPageWikiLinkText "terminators".
- Termination_factor wikiPageUsesTemplate Template:Citation_needed.
- Termination_factor wikiPageUsesTemplate Template:Genetics-stub.
- Termination_factor wikiPageUsesTemplate Template:Refimprove.
- Termination_factor wikiPageUsesTemplate Template:Reflist.
- Termination_factor subject Category:Gene_expression.
- Termination_factor subject Category:Molecular_genetics.
- Termination_factor hypernym Part.
- Termination_factor type Process.
- Termination_factor comment "Termination is part of the process of transcribing RNA. In eukaryotes, a termination factor is required to release the newly made (nascent) RNA from the transcription complex.".
- Termination_factor label "Termination factor".
- Termination_factor sameAs Q7702794.
- Termination_factor sameAs m.08524b.
- Termination_factor sameAs Фактори_термінації_транскрипції.
- Termination_factor sameAs Q7702794.
- Termination_factor wasDerivedFrom Termination_factor?oldid=695887274.
- Termination_factor isPrimaryTopicOf Termination_factor.