Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Terfenadine> ?p ?o }
- Terfenadine abstract "Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi-Aventis) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from markets worldwide.Terfenadine is a prodrug, generally completely metabolized to the active form fexofenadine in the liver by the enzyme Cytochrome P450 3A4Due to its near complete metabolism by the liver immediately after leaving the gut, terfenadine normally is not measurable in the plasma. Terfenadine itself, however, is cardiotoxic at higher doses, while its major active metabolite is not. Terfenadine, in addition to its antihistamine effects, also acts as a potassium channel blocker (Kv11.1 encoded by the gene hERG). Since its active metabolite is not a potassium channel blocker, no cardiotoxicity is associated with fexofenadine. Toxicity is possible after years of continued use with no previous problems as a result of an interaction with other medications such as erythromycin, or foods such as grapefruit. The addition of, or dosage change in, these CYP3A4 inhibitors makes it harder for the body to metabolize and remove terfenadine. In larger plasma concentrations, it may lead to toxic effects on the heart's rhythm (e.g. ventricular tachycardia and torsades de pointes).".
- Terfenadine atcPrefix "R06".
- Terfenadine atcSuffix "AX12".
- Terfenadine casNumber "50679-08-8".
- Terfenadine drugbank "DB00342".
- Terfenadine fdaUniiCode "7BA5G9Y06Q".
- Terfenadine iupacName "(RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol".
- Terfenadine pubchem "5405".
- Terfenadine thumbnail Terfenadine.svg?width=300.
- Terfenadine wikiPageExternalLink 800A.htm.
- Terfenadine wikiPageID "2161447".
- Terfenadine wikiPageLength "8097".
- Terfenadine wikiPageOutDegree "41".
- Terfenadine wikiPageRevisionID "707073190".
- Terfenadine wikiPageWikiLink Allergic_rhinitis.
- Terfenadine wikiPageWikiLink Allergy.
- Terfenadine wikiPageWikiLink Antihistamine.
- Terfenadine wikiPageWikiLink Azacyclonol.
- Terfenadine wikiPageWikiLink Boxed_warning.
- Terfenadine wikiPageWikiLink CYP3A4.
- Terfenadine wikiPageWikiLink Cardiac_arrhythmia.
- Terfenadine wikiPageWikiLink Cardiotoxicity.
- Terfenadine wikiPageWikiLink Category:1985_introductions.
- Terfenadine wikiPageWikiLink Category:Alcohols.
- Terfenadine wikiPageWikiLink Category:German_inventions.
- Terfenadine wikiPageWikiLink Category:H1_receptor_antagonists.
- Terfenadine wikiPageWikiLink Category:Peripherally_selective_drugs.
- Terfenadine wikiPageWikiLink Category:Piperidines.
- Terfenadine wikiPageWikiLink Category:Prodrugs.
- Terfenadine wikiPageWikiLink Category:Withdrawn_drugs.
- Terfenadine wikiPageWikiLink Ebastine.
- Terfenadine wikiPageWikiLink Erythromycin.
- Terfenadine wikiPageWikiLink Fexofenadine.
- Terfenadine wikiPageWikiLink Food_and_Drug_Administration.
- Terfenadine wikiPageWikiLink Grapefruit–drug_interactions.
- Terfenadine wikiPageWikiLink HERG.
- Terfenadine wikiPageWikiLink Hoechst_AG.
- Terfenadine wikiPageWikiLink Ketoconazole.
- Terfenadine wikiPageWikiLink Macrolide.
- Terfenadine wikiPageWikiLink Prodrug.
- Terfenadine wikiPageWikiLink Pseudoephedrine.
- Terfenadine wikiPageWikiLink QT_interval.
- Terfenadine wikiPageWikiLink Racemic_mixture.
- Terfenadine wikiPageWikiLink Risk_factor.
- Terfenadine wikiPageWikiLink Sanofi.
- Terfenadine wikiPageWikiLink Teva_Active_Pharmaceutical_Ingredients_(TAPI).
- Terfenadine wikiPageWikiLink Torsades_de_pointes.
- Terfenadine wikiPageWikiLink Ventricular_tachycardia.
- Terfenadine wikiPageWikiLink Wikt:concomitant.
- Terfenadine wikiPageWikiLinkText "Seldane".
- Terfenadine wikiPageWikiLinkText "Terfenadine".
- Terfenadine wikiPageWikiLinkText "terfenadine".
- Terfenadine atcPrefix "R06".
- Terfenadine atcSuffix "AX12".
- Terfenadine c "32".
- Terfenadine casNumber "50679".
- Terfenadine chembl "17157".
- Terfenadine chemspiderid "5212".
- Terfenadine chirality Racemic_mixture.
- Terfenadine drugbank "DB00342".
- Terfenadine eliminationHalfLife "12600.0".
- Terfenadine h "41".
- Terfenadine inchi "1".
- Terfenadine inchikey "GUGOEEXESWIERI-UHFFFAOYAL".
- Terfenadine iupacName "-1".
- Terfenadine iupharLigand "2608".
- Terfenadine kegg "D00521".
- Terfenadine legalStatus "Withdrawn".
- Terfenadine medlineplus "a600034".
- Terfenadine molecularWeight "471.673".
- Terfenadine n "1".
- Terfenadine o "2".
- Terfenadine pregnancyUs "C".
- Terfenadine proteinBound "70.0".
- Terfenadine pubchem "5405".
- Terfenadine smiles "OCC4CCNCC4".
- Terfenadine stdinchi "1".
- Terfenadine stdinchikey "GUGOEEXESWIERI-UHFFFAOYSA-N".
- Terfenadine tradename "Seldane, Triludan, Teldane".
- Terfenadine unii "7".
- Terfenadine verifiedfields "changed".
- Terfenadine verifiedrevid "470602363".
- Terfenadine wikiPageUsesTemplate Template:Antihistamines.
- Terfenadine wikiPageUsesTemplate Template:Cascite.
- Terfenadine wikiPageUsesTemplate Template:Chemspidercite.
- Terfenadine wikiPageUsesTemplate Template:Drugbankcite.
- Terfenadine wikiPageUsesTemplate Template:Drugbox.
- Terfenadine wikiPageUsesTemplate Template:Drugs.com.
- Terfenadine wikiPageUsesTemplate Template:Ebicite.
- Terfenadine wikiPageUsesTemplate Template:Fdacite.
- Terfenadine wikiPageUsesTemplate Template:Histaminergics.
- Terfenadine wikiPageUsesTemplate Template:Keggcite.
- Terfenadine wikiPageUsesTemplate Template:PAF_signaling.
- Terfenadine wikiPageUsesTemplate Template:Reflist.
- Terfenadine wikiPageUsesTemplate Template:Rp.
- Terfenadine wikiPageUsesTemplate Template:Stdinchicite.
- Terfenadine subject Category:1985_introductions.
- Terfenadine subject Category:Alcohols.
- Terfenadine subject Category:German_inventions.
- Terfenadine subject Category:H1_receptor_antagonists.