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- Tenofovir_alafenamide abstract "Tenofovir alafenamide (INN/USAN, formerly GS-7340) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil, TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent.Gilead announced a phase 3 clinical trial evaluating a single-tablet regimen combining tenofovir alafenamide with cobicistat, emtricitabine and elvitegravir and developed a coformulation of the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48 week study comparing elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (trade name Genvoya), the results showed the newer drug to be noninferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. Genvoya is the first TAF-based regimen to receive approval.".
- Tenofovir_alafenamide atcPrefix "J05".
- Tenofovir_alafenamide atcSuffix "AR17".
- Tenofovir_alafenamide atcSupplemental "(combination codes)".
- Tenofovir_alafenamide casNumber "379270-37-8".
- Tenofovir_alafenamide chEBI "90926".
- Tenofovir_alafenamide drugbank "DB09299".
- Tenofovir_alafenamide fdaUniiCode "EL9943AG5J".
- Tenofovir_alafenamide iupacName "Isopropyl (2S)-2-[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]propanoate".
- Tenofovir_alafenamide pubchem "9574768".
- Tenofovir_alafenamide thumbnail Tenofovir_alafenamide_structure.svg?width=300.
- Tenofovir_alafenamide wikiPageID "33774850".
- Tenofovir_alafenamide wikiPageLength "8485".
- Tenofovir_alafenamide wikiPageOutDegree "33".
- Tenofovir_alafenamide wikiPageRevisionID "707928918".
- Tenofovir_alafenamide wikiPageWikiLink Carboxylesterase_1.
- Tenofovir_alafenamide wikiPageWikiLink Category:Antiretroviral_drugs.
- Tenofovir_alafenamide wikiPageWikiLink Cathepsin_A.
- Tenofovir_alafenamide wikiPageWikiLink Cobicistat.
- Tenofovir_alafenamide wikiPageWikiLink Darunavir.
- Tenofovir_alafenamide wikiPageWikiLink Elvitegravir.
- Tenofovir_alafenamide wikiPageWikiLink tenofovir.
- Tenofovir_alafenamide wikiPageWikiLink Emtricitabine.
- Tenofovir_alafenamide wikiPageWikiLink Fixed-dose_combination_(antiretroviral).
- Tenofovir_alafenamide wikiPageWikiLink Fumaric_acid.
- Tenofovir_alafenamide wikiPageWikiLink Gilead_Sciences.
- Tenofovir_alafenamide wikiPageWikiLink HINT1.
- Tenofovir_alafenamide wikiPageWikiLink HIV.
- Tenofovir_alafenamide wikiPageWikiLink Hepatitis_B.
- Tenofovir_alafenamide wikiPageWikiLink Hepatitis_C_virus.
- Tenofovir_alafenamide wikiPageWikiLink International_nonproprietary_name.
- Tenofovir_alafenamide wikiPageWikiLink Lymphatic_system.
- Tenofovir_alafenamide wikiPageWikiLink NS5B.
- Tenofovir_alafenamide wikiPageWikiLink Nucleotide.
- Tenofovir_alafenamide wikiPageWikiLink Phases_of_clinical_research.
- Tenofovir_alafenamide wikiPageWikiLink Prodrug.
- Tenofovir_alafenamide wikiPageWikiLink Protease_inhibitor_(pharmacology).
- Tenofovir_alafenamide wikiPageWikiLink RNA_polymerase.
- Tenofovir_alafenamide wikiPageWikiLink Reverse-transcriptase_inhibitor.
- Tenofovir_alafenamide wikiPageWikiLink Sofosbuvir.
- Tenofovir_alafenamide wikiPageWikiLink Tablet_(pharmacy).
- Tenofovir_alafenamide wikiPageWikiLink Tenofovir_disoproxil.
- Tenofovir_alafenamide wikiPageWikiLink United_States_Adopted_Name.
- Tenofovir_alafenamide wikiPageWikiLink nowiki%3E(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy%5Dmethyl-phenoxy-phosphoryl%5Damino%5Dpropanoate.
- Tenofovir_alafenamide wikiPageWikiLink File:Tenofovir_alafenamide_fumarate.svg.
- Tenofovir_alafenamide wikiPageWikiLinkText "Tenofovir alafenamide".
- Tenofovir_alafenamide wikiPageWikiLinkText "tenofovir alafenamide".
- Tenofovir_alafenamide atcPrefix "J05".
- Tenofovir_alafenamide atcSuffix "AR17".
- Tenofovir_alafenamide c "21".
- Tenofovir_alafenamide casNumber "379270".
- Tenofovir_alafenamide chebi "90926".
- Tenofovir_alafenamide chembl "2107825".
- Tenofovir_alafenamide chemspiderid "7849225".
- Tenofovir_alafenamide drugbank "DB09299".
- Tenofovir_alafenamide eliminationHalfLife "1836.0".
- Tenofovir_alafenamide excretion "Feces , urine".
- Tenofovir_alafenamide h "29".
- Tenofovir_alafenamide iupacName "Isopropyl -2-[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]propanoate".
- Tenofovir_alafenamide kegg "D10428".
- Tenofovir_alafenamide legalStatus "Rx-only".
- Tenofovir_alafenamide molecularWeight "476.466".
- Tenofovir_alafenamide n "6".
- Tenofovir_alafenamide o "5".
- Tenofovir_alafenamide p "1".
- Tenofovir_alafenamide proteinBound "~80%".
- Tenofovir_alafenamide pubchem "9574768".
- Tenofovir_alafenamide routesOfAdministration "Oral".
- Tenofovir_alafenamide smiles "C[C@H]OC[P@@]OC3=CC=CC=C3".
- Tenofovir_alafenamide stdinchi "1".
- Tenofovir_alafenamide stdinchikey "LDEKQSIMHVQZJK-CAQYMETFSA-N".
- Tenofovir_alafenamide tradename "Genvoya".
- Tenofovir_alafenamide unii "EL9943AG5J".
- Tenofovir_alafenamide width "250".
- Tenofovir_alafenamide wikiPageUsesTemplate Template:ATC.
- Tenofovir_alafenamide wikiPageUsesTemplate Template:Antiinfective-drug-stub.
- Tenofovir_alafenamide wikiPageUsesTemplate Template:Antiretroviral_drug.
- Tenofovir_alafenamide wikiPageUsesTemplate Template:Drugbox.
- Tenofovir_alafenamide wikiPageUsesTemplate Template:Ebicite.
- Tenofovir_alafenamide wikiPageUsesTemplate Template:Fdacite.
- Tenofovir_alafenamide wikiPageUsesTemplate Template:Reflist.
- Tenofovir_alafenamide subject Category:Antiretroviral_drugs.
- Tenofovir_alafenamide hypernym Inhibitor.
- Tenofovir_alafenamide type ChemicalSubstance.
- Tenofovir_alafenamide type Drug.
- Tenofovir_alafenamide type Chemical.
- Tenofovir_alafenamide type ChemicalObject.
- Tenofovir_alafenamide type Thing.
- Tenofovir_alafenamide type Q8386.
- Tenofovir_alafenamide comment "Tenofovir alafenamide (INN/USAN, formerly GS-7340) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF).".
- Tenofovir_alafenamide label "Tenofovir alafenamide".
- Tenofovir_alafenamide sameAs Q22075912.
- Tenofovir_alafenamide sameAs m.0hhq318.
- Tenofovir_alafenamide sameAs Тенофовир_алафенамид.
- Tenofovir_alafenamide sameAs Q22075912.
- Tenofovir_alafenamide wasDerivedFrom Tenofovir_alafenamide?oldid=707928918.
- Tenofovir_alafenamide depiction Tenofovir_alafenamide_structure.svg.
- Tenofovir_alafenamide isPrimaryTopicOf Tenofovir_alafenamide.
