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- Tenecteplase abstract "Tenecteplase (INN) (trade name TNKase) is an enzyme used as a thrombolytic drug.Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.The abbreviation TNK is common for referring to tenecteplase, but abbreviating drug names is not best practice in medicine, and in fact \"TNK\" is one of the examples given on the Institute for Safe Medication Practices (ISMP) do-not-use list.".
- Tenecteplase atcPrefix "B01".
- Tenecteplase atcSuffix "AD11".
- Tenecteplase casNumber "105857-23-6".
- Tenecteplase drugbank "DB00031".
- Tenecteplase fdaUniiCode "WGD229O42W".
- Tenecteplase iupacName "Human tissue plasminogen activator".
- Tenecteplase wikiPageExternalLink 3905512.
- Tenecteplase wikiPageID "6046521".
- Tenecteplase wikiPageLength "7783".
- Tenecteplase wikiPageOutDegree "13".
- Tenecteplase wikiPageRevisionID "691517267".
- Tenecteplase wikiPageWikiLink Alanine.
- Tenecteplase wikiPageWikiLink Arginine.
- Tenecteplase wikiPageWikiLink Best_practice.
- Tenecteplase wikiPageWikiLink Category:Antithrombotic_enzymes.
- Tenecteplase wikiPageWikiLink Chinese_hamster_ovary_cell.
- Tenecteplase wikiPageWikiLink Enzyme.
- Tenecteplase wikiPageWikiLink Histidine.
- Tenecteplase wikiPageWikiLink International_nonproprietary_name.
- Tenecteplase wikiPageWikiLink Lysine.
- Tenecteplase wikiPageWikiLink Plasminogen_activator_inhibitor-1.
- Tenecteplase wikiPageWikiLink Thrombolytic_drug.
- Tenecteplase wikiPageWikiLink Tissue_plasminogen_activator.
- Tenecteplase wikiPageWikiLinkText "Tenecteplase".
- Tenecteplase wikiPageWikiLinkText "tenecteplase".
- Tenecteplase atcPrefix "B01".
- Tenecteplase atcSuffix "AD11".
- Tenecteplase c "2561".
- Tenecteplase casNumber "105857".
- Tenecteplase chemspiderid "none".
- Tenecteplase drugbank "DB00031".
- Tenecteplase excretion "Liver".
- Tenecteplase h "3919".
- Tenecteplase iupacName "Human tissue plasminogen activator".
- Tenecteplase kegg "D02837".
- Tenecteplase legalStatus "Rx".
- Tenecteplase molecularWeight "58951.2".
- Tenecteplase n "747".
- Tenecteplase o "781".
- Tenecteplase s "40".
- Tenecteplase tradename "TNKase".
- Tenecteplase unii "WGD229O42W".
- Tenecteplase verifiedrevid "477861633".
- Tenecteplase wikiPageUsesTemplate Template:Antithrombotics.
- Tenecteplase wikiPageUsesTemplate Template:Cascite.
- Tenecteplase wikiPageUsesTemplate Template:Chemspidercite.
- Tenecteplase wikiPageUsesTemplate Template:Cite_journal.
- Tenecteplase wikiPageUsesTemplate Template:Drugbankcite.
- Tenecteplase wikiPageUsesTemplate Template:Drugbox.
- Tenecteplase wikiPageUsesTemplate Template:Drugs.com.
- Tenecteplase wikiPageUsesTemplate Template:Fdacite.
- Tenecteplase wikiPageUsesTemplate Template:Gallery.
- Tenecteplase wikiPageUsesTemplate Template:Keggcite.
- Tenecteplase wikiPageUsesTemplate Template:MedlinePlusDrugInfo.
- Tenecteplase wikiPageUsesTemplate Template:More_footnotes.
- Tenecteplase wikiPageUsesTemplate Template:Refbegin.
- Tenecteplase wikiPageUsesTemplate Template:Refend.
- Tenecteplase wikiPageUsesTemplate Template:Reflist.
- Tenecteplase subject Category:Antithrombotic_enzymes.
- Tenecteplase hypernym Enzyme.
- Tenecteplase type Agent.
- Tenecteplase type ChemicalSubstance.
- Tenecteplase type Drug.
- Tenecteplase type Protein.
- Tenecteplase type Agent.
- Tenecteplase type Chemical.
- Tenecteplase type Redirect.
- Tenecteplase type ChemicalObject.
- Tenecteplase type Thing.
- Tenecteplase type Q8386.
- Tenecteplase comment "Tenecteplase (INN) (trade name TNKase) is an enzyme used as a thrombolytic drug.Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells).".
- Tenecteplase label "Tenecteplase".
- Tenecteplase sameAs Q1644947.
- Tenecteplase sameAs تنکتپلاز.
- Tenecteplase sameAs Tenecteplase.
- Tenecteplase sameAs Tenecteplase.
- Tenecteplase sameAs m.0fmc7w.
- Tenecteplase sameAs Тенектеплаза.
- Tenecteplase sameAs Tenekteplaza.
- Tenecteplase sameAs Tenekteplaza.
- Tenecteplase sameAs Q1644947.
- Tenecteplase wasDerivedFrom Tenecteplase?oldid=691517267.
- Tenecteplase isPrimaryTopicOf Tenecteplase.