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- Tartrate-resistant_acid_phosphatase abstract "Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5), is a glycosylated monomeric metalloprotein enzyme expressed in mammals. It has a molecular weight of approximately 35kDa, a basic isoelectric point (7.6-9.5), and optimal activity in acidic conditions. TRAP is synthesized as latent proenzyme and activated by proteolytic cleavage and reduction. It is differentiated from other mammalian acid phosphatases by its resistance to inhibition by tartrate, molecular weight and characteristic purple colour.The mechanism of phosphate ester hydrolysis by TRAP is through a nucleophilic attack mechanism, whereby, catalysis occurs with the binding of a phosphate-substrate to the Fe2+ in the active site of TRAP. This is then followed by a nucleophilic attack by a hydroxide ligand on the bound phosphorus atom, resulting in cleavage of the phosphate ester bond and production of an alcohol. The exact identity and mechanism of the hydroxide ligand is unclear, but it is thought to be either a hydroxide that bridges the metal ions within the active site or a terminal hydroxide bound to Fe3+, with conflicting reports for both mechanisms.".
- Tartrate-resistant_acid_phosphatase entrezgene "54".
- Tartrate-resistant_acid_phosphatase wikiPageID "8811367".
- Tartrate-resistant_acid_phosphatase wikiPageLength "13041".
- Tartrate-resistant_acid_phosphatase wikiPageOutDegree "37".
- Tartrate-resistant_acid_phosphatase wikiPageRevisionID "701366290".
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Bone_sialoprotein.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Bone_synthesis.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Category:EC_3.1.3.2.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Cell_growth.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Cell_migration.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Cellular_differentiation.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Dephosphorylation.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Enzyme.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Femur.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Gauchers_disease.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Giant-cell_tumor_of_bone.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Glycosylation.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink HIV-induced_encephalopathy.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Hairy_cell_leukemia.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Hydrogen_peroxide.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Hydroxyl_radical.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Isoelectric_point.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Macrophage.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Metalloprotein.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Microphthalmia-associated_transcription_factor.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Monomer.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Neuron.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Osteoblast.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Osteoclast.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Osteopetrosis.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Osteopontin.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Osteoporosis.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Phosphatase.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Promoter_(genetics).
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Protease.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Protein_sequencing.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Reactive_oxygen_species.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Substrate_(chemistry).
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Superoxide.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLink Zymogen.
- Tartrate-resistant_acid_phosphatase wikiPageWikiLinkText "Tartrate-resistant acid phosphatase".
- Tartrate-resistant_acid_phosphatase wikiPageWikiLinkText "tartrate-resistant acid phosphatase".
- Tartrate-resistant_acid_phosphatase requireManualInspection "no".
- Tartrate-resistant_acid_phosphatase updateCitations "no".
- Tartrate-resistant_acid_phosphatase updatePage "yes".
- Tartrate-resistant_acid_phosphatase updateProteinBox "yes".
- Tartrate-resistant_acid_phosphatase updateSummary "no".
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:Enzymes.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:Esterases.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:MeshName.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:PBB.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:PBB_Controls.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:PDB_Gallery.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:Portal_bar.
- Tartrate-resistant_acid_phosphatase wikiPageUsesTemplate Template:Reflist.
- Tartrate-resistant_acid_phosphatase subject Category:EC_3.1.3.2.
- Tartrate-resistant_acid_phosphatase hypernym Enzyme.
- Tartrate-resistant_acid_phosphatase type Biomolecule.
- Tartrate-resistant_acid_phosphatase type Protein.
- Tartrate-resistant_acid_phosphatase type Thing.
- Tartrate-resistant_acid_phosphatase type Q206229.
- Tartrate-resistant_acid_phosphatase type Q8054.
- Tartrate-resistant_acid_phosphatase comment "Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5), is a glycosylated monomeric metalloprotein enzyme expressed in mammals. It has a molecular weight of approximately 35kDa, a basic isoelectric point (7.6-9.5), and optimal activity in acidic conditions. TRAP is synthesized as latent proenzyme and activated by proteolytic cleavage and reduction.".
- Tartrate-resistant_acid_phosphatase label "Tartrate-resistant acid phosphatase".
- Tartrate-resistant_acid_phosphatase sameAs Q14907831.
- Tartrate-resistant_acid_phosphatase sameAs m.027klkw.
- Tartrate-resistant_acid_phosphatase sameAs Q14907831.
- Tartrate-resistant_acid_phosphatase wasDerivedFrom Tartrate-resistant_acid_phosphatase?oldid=701366290.
- Tartrate-resistant_acid_phosphatase isPrimaryTopicOf Tartrate-resistant_acid_phosphatase.