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- T_helper_3_cell abstract "T helper 3 cells are a type of T helper cell, lymphocytes involved in regulating the immune response.T helper cells in general mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity.This is of special importance in the gut as it is there where the highest load of foreign material, food, is present.TH3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from nonpathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and IL-10. TGF-beta promotes the class switch to low concentrations of IgA which is noninflammatory. IgA does not usually activate the complement system and is not involved with phagocytosis. TH3 inhibits TH1 and TH2 cells. T helper 3 cell (Th3) have different cytokine requirements for their growth from CD25+ CD4+ Treg cells. The survival of CD25+ CD4+ Treg cells is dependent upon interleukin 2 (IL-2), while in vitro differentiation of Th3 cells is enhanced by transforming growth factor beta (TGF-β), IL-4, and IL-10.Findings suggest that Th3 cells are a different linage from naturally arising CD25+ CD4+ Treg cells, but it is still unclear whether Th3 cells are the same as induced Treg cells because of the lack of a specific marker for Th3 cells. It was previously shown that TGF-β was produced by intestinal dendritic cells, which has been considered to be the source of cytokines for the induction of Th3 cells in the intestine. Additionally, since TGF-β production was induced by cytotoxic T-lymphocyte antigen 4 (CTLA-4), which is constitutively expressed on naturally arising Treg cells, it is possible that TGF-β production from Treg cells through CTLA-4–mediated signaling may stimulate the differentiation of both induced Treg cells and Th3 cells.".
- T_helper_3_cell wikiPageID "19612979".
- T_helper_3_cell wikiPageLength "3449".
- T_helper_3_cell wikiPageOutDegree "17".
- T_helper_3_cell wikiPageRevisionID "690486726".
- T_helper_3_cell wikiPageWikiLink B_cell.
- T_helper_3_cell wikiPageWikiLink CTLA-4.
- T_helper_3_cell wikiPageWikiLink Category:T_cells.
- T_helper_3_cell wikiPageWikiLink Cytokine.
- T_helper_3_cell wikiPageWikiLink Dendritic_cell.
- T_helper_3_cell wikiPageWikiLink In_vitro.
- T_helper_3_cell wikiPageWikiLink Interleukin_10.
- T_helper_3_cell wikiPageWikiLink Interleukin_2.
- T_helper_3_cell wikiPageWikiLink Interleukin_4.
- T_helper_3_cell wikiPageWikiLink Lymphocyte.
- T_helper_3_cell wikiPageWikiLink Regulatory_T_cell.
- T_helper_3_cell wikiPageWikiLink T_helper_cell.
- T_helper_3_cell wikiPageWikiLink Transforming_growth_factor_beta.
- T_helper_3_cell wikiPageWikiLinkText "T helper 3 cell".
- T_helper_3_cell wikiPageWikiLinkText "TH3".
- T_helper_3_cell wikiPageWikiLinkText "Th3 cells".
- T_helper_3_cell wikiPageUsesTemplate Template:Context.
- T_helper_3_cell wikiPageUsesTemplate Template:Immunology-stub.
- T_helper_3_cell wikiPageUsesTemplate Template:Lymphocytes.
- T_helper_3_cell wikiPageUsesTemplate Template:Reflist.
- T_helper_3_cell subject Category:T_cells.
- T_helper_3_cell hypernym Cell.
- T_helper_3_cell type AnatomicalStructure.
- T_helper_3_cell type Cell.
- T_helper_3_cell type Page.
- T_helper_3_cell comment "T helper 3 cells are a type of T helper cell, lymphocytes involved in regulating the immune response.T helper cells in general mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity.This is of special importance in the gut as it is there where the highest load of foreign material, food, is present.TH3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from nonpathogenic non-self antigens.".
- T_helper_3_cell label "T helper 3 cell".
- T_helper_3_cell sameAs Q7672695.
- T_helper_3_cell sameAs m.04n2fyd.
- T_helper_3_cell sameAs Q7672695.
- T_helper_3_cell wasDerivedFrom T_helper_3_cell?oldid=690486726.
- T_helper_3_cell isPrimaryTopicOf T_helper_3_cell.