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- TRPC abstract "TRPC is a family of transient receptor potential cation channels in animals.TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. In terms of structure, this family possesses a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble.The predominant TRPC channels in the mammalian brain are the TRPC 1,4 and 5 and they are densely expressed in corticolimbic brain regions, like the hippocampus, prefrontal cortex and lateral septum. The TRPC channels 1,4 and 5 functional group is activated by the metabotropic glutamate receptor group 1 agonist DHPG.In general, TRPC channels can be activated by phospholipase C stimulation, with some members also activated by diacylglycerol. There is one at least one report that TRPC1 is also activated by stretching of the membrane and TRPC5 channels are activated by extracellular reduced thioredoxin.It has long been proposed that TRPC channels underlie the store-operated channels (SOC) observed in many cell types. These channels open due to the depletion of intracellular calcium stores. Two other proteins, stromal interaction molecules (STIMs) and the ORAIs, however, have more recently been implicated in this process. STIM1 and TRPC1 can coassemble, complicating the understanding of this phenomenon.TRPC6 has been implicated in late onset Alzheimer's disease.".
- TRPC wikiPageExternalLink FamilyMenuForward?familyId=12.
- TRPC wikiPageExternalLink www.trpchannel.org.
- TRPC wikiPageID "9725350".
- TRPC wikiPageLength "10064".
- TRPC wikiPageOutDegree "40".
- TRPC wikiPageRevisionID "697974965".
- TRPC wikiPageWikiLink Angiotensin.
- TRPC wikiPageWikiLink Ankyrin.
- TRPC wikiPageWikiLink Atrial_fibrillation.
- TRPC wikiPageWikiLink Calcineurin.
- TRPC wikiPageWikiLink Cardiac_muscle_cell.
- TRPC wikiPageWikiLink Cardiomyopathy.
- TRPC wikiPageWikiLink Cardiovascular_disease.
- TRPC wikiPageWikiLink Category:Ion_channels.
- TRPC wikiPageWikiLink Category:Membrane_biology.
- TRPC wikiPageWikiLink Diglyceride.
- TRPC wikiPageWikiLink Endothelium.
- TRPC wikiPageWikiLink Fibroblast.
- TRPC wikiPageWikiLink G_protein–coupled_receptor.
- TRPC wikiPageWikiLink Hypertension.
- TRPC wikiPageWikiLink Hypertrophy.
- TRPC wikiPageWikiLink Inositol_trisphosphate.
- TRPC wikiPageWikiLink Ion_channel.
- TRPC wikiPageWikiLink NFAT.
- TRPC wikiPageWikiLink Pharmacotherapy.
- TRPC wikiPageWikiLink Phospholipase_C.
- TRPC wikiPageWikiLink Positive_feedback.
- TRPC wikiPageWikiLink Protein_targeting.
- TRPC wikiPageWikiLink STIM1.
- TRPC wikiPageWikiLink Smooth_muscle_tissue.
- TRPC wikiPageWikiLink TRPC1.
- TRPC wikiPageWikiLink TRPC2.
- TRPC wikiPageWikiLink TRPC3.
- TRPC wikiPageWikiLink TRPC4.
- TRPC wikiPageWikiLink TRPC5.
- TRPC wikiPageWikiLink TRPC6.
- TRPC wikiPageWikiLink TRPC7.
- TRPC wikiPageWikiLink Thioredoxin.
- TRPC wikiPageWikiLink Transient_receptor_potential_channel.
- TRPC wikiPageWikiLinkText "TRPC".
- TRPC wikiPageWikiLinkText "transient receptor potential canonical (TRPC) family channels".
- TRPC wikiPageWikiLinkText "transient receptor potential canonical".
- TRPC wikiPageUsesTemplate Template:Cite_web.
- TRPC wikiPageUsesTemplate Template:Ion_channels.
- TRPC wikiPageUsesTemplate Template:MeshName.
- TRPC wikiPageUsesTemplate Template:Reflist.
- TRPC subject Category:Ion_channels.
- TRPC subject Category:Membrane_biology.
- TRPC hypernym Family.
- TRPC type Biophysic.
- TRPC type Channel.
- TRPC comment "TRPC is a family of transient receptor potential cation channels in animals.TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. In terms of structure, this family possesses a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus.".
- TRPC label "TRPC".
- TRPC sameAs Q7671459.
- TRPC sameAs m.02pq8zk.
- TRPC sameAs Q7671459.
- TRPC wasDerivedFrom TRPC?oldid=697974965.
- TRPC isPrimaryTopicOf TRPC.