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- TNK2 abstract "Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.".
- TNK2 entrezgene "10188".
- TNK2 wikiPageID "14755861".
- TNK2 wikiPageLength "13562".
- TNK2 wikiPageOutDegree "10".
- TNK2 wikiPageRevisionID "699224536".
- TNK2 wikiPageWikiLink Androgen_receptor.
- TNK2 wikiPageWikiLink Ataxia_telangiectasia_mutated.
- TNK2 wikiPageWikiLink Category:Tyrosine_kinases.
- TNK2 wikiPageWikiLink Enzyme.
- TNK2 wikiPageWikiLink FYN.
- TNK2 wikiPageWikiLink GRB2.
- TNK2 wikiPageWikiLink Gene.
- TNK2 wikiPageWikiLink Protein_kinase_B.
- TNK2 wikiPageWikiLink Protein–protein_interaction.
- TNK2 wikiPageWikiLink WWOX.
- TNK2 wikiPageWikiLinkText "ACK".
- TNK2 wikiPageWikiLinkText "ACK1".
- TNK2 wikiPageWikiLinkText "Activated CDC42 kinase 1 (Ack1)".
- TNK2 wikiPageWikiLinkText "TNK2".
- TNK2 requireManualInspection "no".
- TNK2 summaryText "TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor . ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.".
- TNK2 updateCitations "yes".
- TNK2 updatePage "yes".
- TNK2 updateProteinBox "yes".
- TNK2 updateSummary "yes".
- TNK2 wikiPageUsesTemplate Template:Cite_journal.
- TNK2 wikiPageUsesTemplate Template:Enzymes.
- TNK2 wikiPageUsesTemplate Template:PBB.
- TNK2 wikiPageUsesTemplate Template:PBB_Controls.
- TNK2 wikiPageUsesTemplate Template:PBB_Further_reading.
- TNK2 wikiPageUsesTemplate Template:PBB_Summary.
- TNK2 wikiPageUsesTemplate Template:PDB_Gallery.
- TNK2 wikiPageUsesTemplate Template:Portal_bar.
- TNK2 wikiPageUsesTemplate Template:Refbegin.
- TNK2 wikiPageUsesTemplate Template:Refend.
- TNK2 wikiPageUsesTemplate Template:Reflist.
- TNK2 wikiPageUsesTemplate Template:Tyrosine_kinases.
- TNK2 wikiPageUsesTemplate Template:UCSC_gene_details.
- TNK2 wikiPageUsesTemplate Template:UCSC_genome_browser.
- TNK2 subject Category:Tyrosine_kinases.
- TNK2 hypernym Enzyme.
- TNK2 type Biomolecule.
- TNK2 type Protein.
- TNK2 type Thing.
- TNK2 type Q206229.
- TNK2 type Q8054.
- TNK2 comment "Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs.".
- TNK2 label "TNK2".
- TNK2 sameAs Q18035104.
- TNK2 sameAs m.03gwtxs.
- TNK2 sameAs TNK2.
- TNK2 sameAs Q18035104.
- TNK2 wasDerivedFrom TNK2?oldid=699224536.
- TNK2 isPrimaryTopicOf TNK2.