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- TIGIT abstract "TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity.Research has shown that TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation in vivo.TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain".
- TIGIT wikiPageID "34344550".
- TIGIT wikiPageLength "5884".
- TIGIT wikiPageOutDegree "21".
- TIGIT wikiPageRevisionID "700680673".
- TIGIT wikiPageWikiLink Antigen.
- TIGIT wikiPageWikiLink CD155.
- TIGIT wikiPageWikiLink Category:Articles_created_via_the_Article_Wizard.
- TIGIT wikiPageWikiLink Category:Human_proteins.
- TIGIT wikiPageWikiLink Dendritic_cell.
- TIGIT wikiPageWikiLink HIV.
- TIGIT wikiPageWikiLink Immune_receptor.
- TIGIT wikiPageWikiLink Immunoreceptor_tyrosine-based_inhibitory_motif.
- TIGIT wikiPageWikiLink In_vivo.
- TIGIT wikiPageWikiLink Interleukin_10.
- TIGIT wikiPageWikiLink Interleukin_12.
- TIGIT wikiPageWikiLink Lipopolysaccharide.
- TIGIT wikiPageWikiLink Macrophage.
- TIGIT wikiPageWikiLink Natural_killer_cell.
- TIGIT wikiPageWikiLink Poliovirus_receptor-related_2.
- TIGIT wikiPageWikiLink Programmed_cell_death_protein_1.
- TIGIT wikiPageWikiLink T_cell.
- TIGIT wikiPageWikiLink T_cell_receptor.
- TIGIT wikiPageWikiLinkText "TIGIT".
- TIGIT wikiPageUsesTemplate Template:Orphan.
- TIGIT wikiPageUsesTemplate Template:Reflist.
- TIGIT subject Category:Articles_created_via_the_Article_Wizard.
- TIGIT subject Category:Human_proteins.
- TIGIT type Biomolecule.
- TIGIT type Biomolecule.
- TIGIT type Nutrient.
- TIGIT comment "TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc.".
- TIGIT label "TIGIT".
- TIGIT sameAs Q7670382.
- TIGIT sameAs TIGIT.
- TIGIT sameAs m.0h_djqb.
- TIGIT sameAs Q7670382.
- TIGIT wasDerivedFrom TIGIT?oldid=700680673.
- TIGIT isPrimaryTopicOf TIGIT.