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- TDP1 abstract "Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.".
- TDP1 entrezgene "55775".
- TDP1 wikiPageExternalLink br.fcgi?book=gene&part=scan1.
- TDP1 wikiPageID "14765183".
- TDP1 wikiPageLength "8253".
- TDP1 wikiPageOutDegree "11".
- TDP1 wikiPageRevisionID "679092037".
- TDP1 wikiPageWikiLink DNA.
- TDP1 wikiPageWikiLink Enzyme.
- TDP1 wikiPageWikiLink Gene.
- TDP1 wikiPageWikiLink Gene_isoform.
- TDP1 wikiPageWikiLink Hydrolysis.
- TDP1 wikiPageWikiLink Mutation.
- TDP1 wikiPageWikiLink Phosphodiester_bond.
- TDP1 wikiPageWikiLink Phospholipase_D.
- TDP1 wikiPageWikiLink Protein.
- TDP1 wikiPageWikiLink Spinocerebellar_ataxia.
- TDP1 wikiPageWikiLink Tyrosine.
- TDP1 wikiPageWikiLinkText "TDP1".
- TDP1 requireManualInspection "no".
- TDP1 summaryText "The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy . While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.".
- TDP1 updateCitations "yes".
- TDP1 updatePage "yes".
- TDP1 updateProteinBox "yes".
- TDP1 updateSummary "yes".
- TDP1 wikiPageUsesTemplate Template:Cite_journal.
- TDP1 wikiPageUsesTemplate Template:Gene-14-stub.
- TDP1 wikiPageUsesTemplate Template:Multiple_issues.
- TDP1 wikiPageUsesTemplate Template:Orphan.
- TDP1 wikiPageUsesTemplate Template:PBB.
- TDP1 wikiPageUsesTemplate Template:PBB_Controls.
- TDP1 wikiPageUsesTemplate Template:PBB_Further_reading.
- TDP1 wikiPageUsesTemplate Template:PBB_Summary.
- TDP1 wikiPageUsesTemplate Template:PDB_Gallery.
- TDP1 wikiPageUsesTemplate Template:Refbegin.
- TDP1 wikiPageUsesTemplate Template:Refend.
- TDP1 wikiPageUsesTemplate Template:Reflist.
- TDP1 wikiPageUsesTemplate Template:Underlinked.
- TDP1 hypernym Enzyme.
- TDP1 type Biomolecule.
- TDP1 type Protein.
- TDP1 type Thing.
- TDP1 type Q206229.
- TDP1 type Q8054.
- TDP1 comment "Tyrosyl-DNA phosphodiesterase 1 is an enzyme that in humans is encoded by the TDP1 gene.The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA.".
- TDP1 label "TDP1".
- TDP1 sameAs Q18042042.
- TDP1 sameAs m.03gx77l.
- TDP1 sameAs Q18042042.
- TDP1 wasDerivedFrom TDP1?oldid=679092037.
- TDP1 isPrimaryTopicOf TDP1.