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- TBC_domain abstract "The TBC (Tre-2/Bub2/Cdc16) is identified as a domain of some proteins or as a protein motif and widely recognized as a conserved one that englobes approximately 200 amino acids in all eukaryotes. However, it was at first identified as a conserved domain among the tre-2 oncogene product and the yeast cell cycle regulators. It has been shown that humans have almost 42 different TBC proteins which differ from each other by having additional motifs and domains (GRAM, RUN, PTB…) and add functional diversification to the family .The most well known of this protein group are TBC1D1 and TBC1D4 which are directly associated with functional diseases. Moreover, most of them have really close relations with other protein domains. For example, it’s been demonstrated that some of them act like a GAP (GTPase-activating protein) for small GTPases: Rab activity is modulated in part by GTPase-activating proteins (GAPs) and many of these RabGAPs share a Tre2/Bub2/Cdc16(TBC)-domain architecture. However, it is needed much research on these kind of proteins and in this article it explains what is known by now.Picture 1. A Rab Cycle in membrane trafficking: The cycle between the GTP-bound inactive state and the GTP- bound active state is leaded by the Rab protein and regulated by an activating enzyme GEF and an inactivating enzyme GAP which in this case could be the TBC protein. Hereafter, the activated form of Rab, GTP-bound, is incorporated to a specific organelle or vesicle and promotes its transport by interacting with a specific effector molecule. GTPase-activating proteins (GAPs) limit the duration of the active state and accelerate the slow intrinsic rate of GTP hydrolysis.".
- TBC_domain wikiPageExternalLink pmidlookup?view=long&pmid=11062263.
- TBC_domain wikiPageExternalLink pmidlookup?view=long&pmid=3356695.
- TBC_domain wikiPageExternalLink B9A6J5.
- TBC_domain wikiPageID "48253250".
- TBC_domain wikiPageLength "10131".
- TBC_domain wikiPageOutDegree "70".
- TBC_domain wikiPageRevisionID "697006432".
- TBC_domain wikiPageWikiLink Amino_acid.
- TBC_domain wikiPageWikiLink Analysis.
- TBC_domain wikiPageWikiLink Cancer.
- TBC_domain wikiPageWikiLink Category:Biology.
- TBC_domain wikiPageWikiLink Category:Cell_biology.
- TBC_domain wikiPageWikiLink Category:Chemistry.
- TBC_domain wikiPageWikiLink Category:Medicine.
- TBC_domain wikiPageWikiLink Category:Molecular_biology.
- TBC_domain wikiPageWikiLink Category:Protein_domains.
- TBC_domain wikiPageWikiLink Category:Science.
- TBC_domain wikiPageWikiLink Cell_(biology).
- TBC_domain wikiPageWikiLink Cell_membrane.
- TBC_domain wikiPageWikiLink Clade.
- TBC_domain wikiPageWikiLink Disease.
- TBC_domain wikiPageWikiLink Effector_(biology).
- TBC_domain wikiPageWikiLink Eukaryote.
- TBC_domain wikiPageWikiLink Evolution.
- TBC_domain wikiPageWikiLink GLUT4.
- TBC_domain wikiPageWikiLink GRAM_domain.
- TBC_domain wikiPageWikiLink GTP.
- TBC_domain wikiPageWikiLink GTPase.
- TBC_domain wikiPageWikiLink GTPase-activating_protein.
- TBC_domain wikiPageWikiLink G_protein.
- TBC_domain wikiPageWikiLink Gene.
- TBC_domain wikiPageWikiLink Genome.
- TBC_domain wikiPageWikiLink Glucose.
- TBC_domain wikiPageWikiLink Gross_domestic_product.
- TBC_domain wikiPageWikiLink Human.
- TBC_domain wikiPageWikiLink In_vitro.
- TBC_domain wikiPageWikiLink Insulin.
- TBC_domain wikiPageWikiLink Interaction.
- TBC_domain wikiPageWikiLink Mammal.
- TBC_domain wikiPageWikiLink Membrane_transport.
- TBC_domain wikiPageWikiLink Membrane_vesicle_trafficking.
- TBC_domain wikiPageWikiLink Molecule.
- TBC_domain wikiPageWikiLink Organelle.
- TBC_domain wikiPageWikiLink Overweight.
- TBC_domain wikiPageWikiLink Phosphotyrosine-binding_domain.
- TBC_domain wikiPageWikiLink Phylogenetics.
- TBC_domain wikiPageWikiLink Protein.
- TBC_domain wikiPageWikiLink Protein_domain.
- TBC_domain wikiPageWikiLink RAB5A.
- TBC_domain wikiPageWikiLink RUN_domain.
- TBC_domain wikiPageWikiLink Rab_(G-protein).
- TBC_domain wikiPageWikiLink Regulator_gene.
- TBC_domain wikiPageWikiLink Scientific_method.
- TBC_domain wikiPageWikiLink Signal_transduction.
- TBC_domain wikiPageWikiLink Structural_motif.
- TBC_domain wikiPageWikiLink TBC1D1.
- TBC_domain wikiPageWikiLink TBC1D4.
- TBC_domain wikiPageWikiLink Target_protein.
- TBC_domain wikiPageWikiLink Vesicle_(biology_and_chemistry).
- TBC_domain wikiPageWikiLink Category:Traffic_Mechanisms.
- TBC_domain wikiPageWikiLinkText "TBC domain".
- TBC_domain wikiPageUsesTemplate Template:Cite_journal.
- TBC_domain wikiPageUsesTemplate Template:Morefootnotes.
- TBC_domain wikiPageUsesTemplate Template:Reflist.
- TBC_domain subject Category:Biology.
- TBC_domain subject Category:Cell_biology.
- TBC_domain subject Category:Chemistry.
- TBC_domain subject Category:Medicine.
- TBC_domain subject Category:Molecular_biology.
- TBC_domain subject Category:Protein_domains.
- TBC_domain subject Category:Science.
- TBC_domain subject Category:Traffic_Mechanisms.
- TBC_domain comment "The TBC (Tre-2/Bub2/Cdc16) is identified as a domain of some proteins or as a protein motif and widely recognized as a conserved one that englobes approximately 200 amino acids in all eukaryotes. However, it was at first identified as a conserved domain among the tre-2 oncogene product and the yeast cell cycle regulators.".
- TBC_domain label "TBC domain".
- TBC_domain wasDerivedFrom TBC_domain?oldid=697006432.
- TBC_domain isPrimaryTopicOf TBC_domain.