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- TBC1D4 abstract "AS160 (Akt substrate of 160 kDa), which was originally known as TBC1 domain family member 4 (TBC1D4), is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene.The 160 kD protein product was first discovered in a screen for novel substrates of the serine-threonine kinase Akt2, which phosphorylates AS160 at Thr-642 and Ser-588 after insulin stimulation. Insulin stimulation of fat and muscle cells results in translocation of the glucose transporter GLUT4 to the plasma membrane, and this translocation process is dependent on phosphorylation of AS160. The role of AS160 in GLUT4 translocation is mediated by its GTPase activating domain and interactions with Rab proteins in vesicle formation, increasing GLUT4 translocation when its GTPase activity is inhibited by Akt phosphorylation. Specifically, this inhibition activates RAB2A, RAB8A, RAB10 and RAB14.AS160 also contains a calmodulin-binding domain, and this domain mediates phosphorylation-independent glucose uptake in muscle cells.".
- TBC1D4 entrezgene "9882".
- TBC1D4 wikiPageID "14816573".
- TBC1D4 wikiPageLength "10314".
- TBC1D4 wikiPageOutDegree "10".
- TBC1D4 wikiPageRevisionID "696077357".
- TBC1D4 wikiPageWikiLink AKT2.
- TBC1D4 wikiPageWikiLink GLUT4.
- TBC1D4 wikiPageWikiLink Gene.
- TBC1D4 wikiPageWikiLink Insulin.
- TBC1D4 wikiPageWikiLink Protein.
- TBC1D4 wikiPageWikiLink RAB10.
- TBC1D4 wikiPageWikiLink RAB14.
- TBC1D4 wikiPageWikiLink RAB2A.
- TBC1D4 wikiPageWikiLink RAB8A.
- TBC1D4 wikiPageWikiLink Rab.
- TBC1D4 wikiPageWikiLinkText "TBC1D4".
- TBC1D4 wikiPageUsesTemplate Template:Cite_journal.
- TBC1D4 wikiPageUsesTemplate Template:Gene-13-stub.
- TBC1D4 wikiPageUsesTemplate Template:PBB.
- TBC1D4 wikiPageUsesTemplate Template:Refbegin.
- TBC1D4 wikiPageUsesTemplate Template:Refend.
- TBC1D4 wikiPageUsesTemplate Template:Reflist.
- TBC1D4 hypernym Protein.
- TBC1D4 type Biomolecule.
- TBC1D4 type Protein.
- TBC1D4 type Thing.
- TBC1D4 type Q206229.
- TBC1D4 type Q8054.
- TBC1D4 comment "AS160 (Akt substrate of 160 kDa), which was originally known as TBC1 domain family member 4 (TBC1D4), is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene.The 160 kD protein product was first discovered in a screen for novel substrates of the serine-threonine kinase Akt2, which phosphorylates AS160 at Thr-642 and Ser-588 after insulin stimulation.".
- TBC1D4 label "TBC1D4".
- TBC1D4 sameAs Q18034838.
- TBC1D4 sameAs m.03gyy6n.
- TBC1D4 sameAs Q18034838.
- TBC1D4 wasDerivedFrom TBC1D4?oldid=696077357.
- TBC1D4 isPrimaryTopicOf TBC1D4.