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- TANK-binding_kinase_1 abstract "Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.".
- TANK-binding_kinase_1 entrezgene "29110".
- TANK-binding_kinase_1 wikiPageID "14754977".
- TANK-binding_kinase_1 wikiPageLength "11489".
- TANK-binding_kinase_1 wikiPageOutDegree "9".
- TANK-binding_kinase_1 wikiPageRevisionID "704366859".
- TANK-binding_kinase_1 wikiPageWikiLink Category:EC_2.7.11.
- TANK-binding_kinase_1 wikiPageWikiLink Enzyme.
- TANK-binding_kinase_1 wikiPageWikiLink Gene.
- TANK-binding_kinase_1 wikiPageWikiLink IKBKE.
- TANK-binding_kinase_1 wikiPageWikiLink IκB_kinase.
- TANK-binding_kinase_1 wikiPageWikiLink NCK1.
- TANK-binding_kinase_1 wikiPageWikiLink Protein–protein_interaction.
- TANK-binding_kinase_1 wikiPageWikiLink TANK_(gene).
- TANK-binding_kinase_1 wikiPageWikiLink TRAF2.
- TANK-binding_kinase_1 wikiPageWikiLinkText "TANK-binding kinase 1".
- TANK-binding_kinase_1 wikiPageWikiLinkText "TBK1".
- TANK-binding_kinase_1 requireManualInspection "no".
- TANK-binding_kinase_1 summaryText "The NF-kappa-B complex of proteins is inhibited by I-kappa-B proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.".
- TANK-binding_kinase_1 updateCitations "yes".
- TANK-binding_kinase_1 updatePage "yes".
- TANK-binding_kinase_1 updateProteinBox "yes".
- TANK-binding_kinase_1 updateSummary "yes".
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Cite_journal.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Div_col.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Div_col_end.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Enzymes.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:PBB.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:PBB_Controls.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:PBB_Further_reading.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:PBB_Summary.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Portal_bar.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Refbegin.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Refend.
- TANK-binding_kinase_1 wikiPageUsesTemplate Template:Reflist.
- TANK-binding_kinase_1 wikiPageUsesTemplate threonine-specific_protein_kinases.
- TANK-binding_kinase_1 subject Category:EC_2.7.11.
- TANK-binding_kinase_1 hypernym Enzyme.
- TANK-binding_kinase_1 type Biomolecule.
- TANK-binding_kinase_1 type Protein.
- TANK-binding_kinase_1 type Thing.
- TANK-binding_kinase_1 type Q206229.
- TANK-binding_kinase_1 type Q8054.
- TANK-binding_kinase_1 comment "Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex.".
- TANK-binding_kinase_1 label "TANK-binding kinase 1".
- TANK-binding_kinase_1 sameAs Q18258483.
- TANK-binding_kinase_1 sameAs m.03gws4y.
- TANK-binding_kinase_1 sameAs Q18258483.
- TANK-binding_kinase_1 wasDerivedFrom TANK-binding_kinase_1?oldid=704366859.
- TANK-binding_kinase_1 isPrimaryTopicOf TANK-binding_kinase_1.