Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Superantigen> ?p ?o }
- Superantigen abstract "Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. SAgs are produced by some pathogenic viruses and bacteria most likely as a defense mechanism against the immune system.Compared to a normal antigen-induced T-cell response where .0001-.001% of the body’s T-cells are activated, these SAgs are capable of activating up to 25% of the body’s T-cells. Furthermore, Anti-CD3 and Anti-CD28 Antibodies (CD28-SuperMAB) have also shown to be highly potent superantigens (and can activate up to 100% of T cells).The large number of activated T-cells generates a massive immune response which is not specific to any particular epitope on the SAg thus undermining one of the fundamental strengths of the adaptive immune system, that is, its ability to target antigens with high specificity. More importantly, the large number of activated T-cells secrete large amounts of cytokines, the most important of which is Interferon gamma. This excess amount of IFN-gamma in turn activates the macrophages. The activated macrophages, in turn, over-produce proinflammatory cytokines such as IL-1, IL-6 and TNF-alpha. TNF-alpha is particularly important as a part of the body's inflammatory response. In normal circumstances it is released locally in low levels and helps the immune system defeat pathogens. However, when it is systemically released in the blood and in high levels (due to mass T-cell activation resulting from the SAg binding), it can cause severe and life-threatening symptoms, including shock and multiple organ failure.".
- Superantigen thumbnail Seb.png?width=300.
- Superantigen wikiPageExternalLink intro.html.
- Superantigen wikiPageExternalLink sagdb.html.
- Superantigen wikiPageExternalLink get-entries?KW=Superantigen.
- Superantigen wikiPageID "1067550".
- Superantigen wikiPageLength "25250".
- Superantigen wikiPageOutDegree "120".
- Superantigen wikiPageRevisionID "679090091".
- Superantigen wikiPageWikiLink Adaptive_immune_system.
- Superantigen wikiPageWikiLink Alpha_helix.
- Superantigen wikiPageWikiLink Antibiotics.
- Superantigen wikiPageWikiLink Antibody.
- Superantigen wikiPageWikiLink Antigen.
- Superantigen wikiPageWikiLink Apoptosis.
- Superantigen wikiPageWikiLink B_cell.
- Superantigen wikiPageWikiLink Bacteria.
- Superantigen wikiPageWikiLink Bacterial_capsule.
- Superantigen wikiPageWikiLink Birkbeck,_University_of_London.
- Superantigen wikiPageWikiLink CCL2.
- Superantigen wikiPageWikiLink CD28.
- Superantigen wikiPageWikiLink CD3_(immunology).
- Superantigen wikiPageWikiLink CD40_(protein).
- Superantigen wikiPageWikiLink Category:Immune_system.
- Superantigen wikiPageWikiLink Category:Toxicology.
- Superantigen wikiPageWikiLink Cell_growth.
- Superantigen wikiPageWikiLink Clonal_anergy.
- Superantigen wikiPageWikiLink Colony.
- Superantigen wikiPageWikiLink Complementarity_determining_region.
- Superantigen wikiPageWikiLink Corticosteroid.
- Superantigen wikiPageWikiLink Cross-link.
- Superantigen wikiPageWikiLink Crystal_structure.
- Superantigen wikiPageWikiLink Cytokine.
- Superantigen wikiPageWikiLink Cytomegalovirus.
- Superantigen wikiPageWikiLink Dermatitis.
- Superantigen wikiPageWikiLink Diabetes_mellitus.
- Superantigen wikiPageWikiLink Ellipsoid.
- Superantigen wikiPageWikiLink Epitope.
- Superantigen wikiPageWikiLink Epstein–Barr_virus.
- Superantigen wikiPageWikiLink Escherichia_coli.
- Superantigen wikiPageWikiLink Evolution.
- Superantigen wikiPageWikiLink FYN.
- Superantigen wikiPageWikiLink Fever.
- Superantigen wikiPageWikiLink Fluid_replacement.
- Superantigen wikiPageWikiLink Foodborne_illness.
- Superantigen wikiPageWikiLink Framework_region.
- Superantigen wikiPageWikiLink Gastrointestinal_tract.
- Superantigen wikiPageWikiLink Globular_cluster.
- Superantigen wikiPageWikiLink HIV.
- Superantigen wikiPageWikiLink HLA-DQ.
- Superantigen wikiPageWikiLink HLA-DR.
- Superantigen wikiPageWikiLink Haematopoiesis.
- Superantigen wikiPageWikiLink Homology_(biology).
- Superantigen wikiPageWikiLink Immunity_(medical).
- Superantigen wikiPageWikiLink Immunoglobulin_E.
- Superantigen wikiPageWikiLink Immunoglobulin_G.
- Superantigen wikiPageWikiLink Immunoglobulin_M.
- Superantigen wikiPageWikiLink Immunoglobulin_class_switching.
- Superantigen wikiPageWikiLink Immunosuppression.
- Superantigen wikiPageWikiLink Inflammation.
- Superantigen wikiPageWikiLink Inotrope.
- Superantigen wikiPageWikiLink Interferon-gamma.
- Superantigen wikiPageWikiLink Interleukin-1_family.
- Superantigen wikiPageWikiLink Interleukin_10.
- Superantigen wikiPageWikiLink Interleukin_2.
- Superantigen wikiPageWikiLink Interleukin_4.
- Superantigen wikiPageWikiLink Interleukin_6.
- Superantigen wikiPageWikiLink Kawasaki_disease.
- Superantigen wikiPageWikiLink Lck.
- Superantigen wikiPageWikiLink Ligand_(biochemistry).
- Superantigen wikiPageWikiLink Lipopolysaccharide.
- Superantigen wikiPageWikiLink MHC_class_II.
- Superantigen wikiPageWikiLink M_protein_(Streptococcus).
- Superantigen wikiPageWikiLink Macrophage.
- Superantigen wikiPageWikiLink Memory_T_cell.
- Superantigen wikiPageWikiLink Monocyte.
- Superantigen wikiPageWikiLink Mouse_mammary_tumor_virus.
- Superantigen wikiPageWikiLink Multiple_organ_dysfunction_syndrome.
- Superantigen wikiPageWikiLink Nasal_polyp.
- Superantigen wikiPageWikiLink Neutrophil_granulocyte.
- Superantigen wikiPageWikiLink Oligonucleotide.
- Superantigen wikiPageWikiLink Oligosaccharide.
- Superantigen wikiPageWikiLink Pathogen.
- Superantigen wikiPageWikiLink Polyclonal_T_cell_activation.
- Superantigen wikiPageWikiLink Polymorphism_(biology).
- Superantigen wikiPageWikiLink Potency_(pharmacology).
- Superantigen wikiPageWikiLink Protein.
- Superantigen wikiPageWikiLink Protein_domain.
- Superantigen wikiPageWikiLink Protein_structure.
- Superantigen wikiPageWikiLink Psoriasis.
- Superantigen wikiPageWikiLink Rabies.
- Superantigen wikiPageWikiLink Rheumatic_fever.
- Superantigen wikiPageWikiLink Rheumatoid_arthritis.
- Superantigen wikiPageWikiLink Scarlet_fever.
- Superantigen wikiPageWikiLink Sepsis.
- Superantigen wikiPageWikiLink Shock_(circulatory).
- Superantigen wikiPageWikiLink Stromal_cell.
- Superantigen wikiPageWikiLink Synergy.
- Superantigen wikiPageWikiLink TGN1412.
- Superantigen wikiPageWikiLink T_cell.