Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Substrate-level_phosphorylation> ?p ?o }
Showing triples 1 to 74 of
74
with 100 triples per page.
- Substrate-level_phosphorylation abstract "Substrate-level phosphorylation is a type of metabolic reaction that results in the formation of adenosine triphosphate (ATP) or guanosine triphosphate (GTP) by the direct transfer and donation of a phosphoryl (PO3) group to adenosine diphosphate (ADP) or guanosine diphosphate (GDP) from a phosphorylated reactive intermediate. Note that the phosphate group does not have to come directly from the substrate. By convention, the phosphoryl group that is transferred is referred to as a phosphate group.An alternative way to create ATP is through oxidative phosphorylation, which takes place during the process of cellular respiration, in addition to the substrate-level phosphorylation that occurs during glycolysis and the Krebs cycle. During oxidative phosphorylation, NADH is oxidized to NAD+, yielding 2.5 ATPs, and FADH2(flavin adenine dinucleotide) yields 1.5 ATPs when it is oxidized. Oxidative phosphorylation uses an electrochemical or chemiosmotic chemiosmosisgradient of protons (H+) across the inner mitochondrial membrane to generate ATP from ADP and a molecule of inorganic phosphate, which is a key difference from substrate-level phosphorylation.Unlike oxidative phosphorylation, oxidation and phosphorylation are not coupled in the process of substrate-level phosphorylation, although both types of phosphorylation result in the formation of ATP, and reactive intermediates are most often gained in course of oxidation processes in catabolism. However, usually most of the ATP is generated by oxidative phosphorylation in aerobic or anaerobic respiration. Substrate-level phosphorylation serves as fast source of ATP independent of external electron acceptors and respiration. This is the case for example in human erythrocytes, which have no mitochondria, and in the muscle during oxygen depression.The main part of substrate-level phosphorylation occurs in the cytoplasm of cells as part of glycolysis and in mitochondria as part of the Krebs Cycle under both aerobic and anaerobic conditions. In the pay-off phase of glycolysis, two ATP are produced by substrate-level phosphorylation: two and only two 1,3-bisphosphoglycerate are converted to 3-phosphoglycerate by transferring a phosphate group to ADP by a kinase; two phosphoenolpyruvate are converted to pyruvate by the transfer of their phosphate groups to ADP by another kinase. The first reaction occurs after the generation of 1,3-bisphosphoglycerate from 3-phosphoglyceraldehyde and an organic phosphate via a dehydrogenase. ATP is generated in a following separate step (key difference from oxidative phosphorylation) by transfer of the high-energy phosphate on 1,3-bisphosphoglycerate to ADP via the enzyme phosphoglycerate kinase, generating 3-phosphoglycerate. As ATP is formed of a former inorganic phosphate group, this step leads to the energy yield of glycolysis.The second substrate-level phosphorylation occurs later by means of the reaction of phosphenolpyruvate (PEP) to pyruvate via the pyruvate kinase. This reaction regenerates the ATP that has been used in the preparatory phase of glycolysis to activate glucose to glucose-6-phosphate and fructose-6-phosphate to fructose-1,6-bisphosphate, respectively.ATP can be generated by substrate-level phosphorylation in the mitochondrial matrix, a pathway that is independent from the proton motive force, PMF. In the mitochondrial matrix there are two reactions capable of substrate-level phosphorylation: the mitochondrial phosphoenolpyruvate carboxykinase, and the succinate-CoA ligase (SUCL or succinate thiokinase or succinyl-CoA synthetase). Mitochondrial phosphoenolpyruvate carboxykinase is thought to participate in the transfer of the phosphorylation potential from the matrix to cytosol and vice versa. Succinate-CoA ligase is a heterodimer, being composed of an invariant alpha subunit, and a substrate-specific beta subunit, encoded by either SUCLA2 or SUCLG2. This dimer combination results in either an ADP-forming succinate-CoA ligase (A-SUCL, EC 6.2.1.5) or a GDP-forming succinate-CoA ligase (G-SUCL, EC 6.2.1.4). The ADP-forming succinate-CoA ligase is potentially the only matrix enzyme generating ATP in the absence of a pmf, capable of maintaining matrix ATP levels under energy-limited conditions, such as transient hypoxia.Another form of substrate-level phosphorylation is also seen in working skeletal muscles and the brain. Phosphocreatine is stored as a readily available high-energy phosphate supply, and the enzyme creatine phosphokinase transfers a phosphate from phosphocreatine to ADP to produce ATP. Then the ATP releases giving chemical energy.Apart from this substrate-level phosphorylation can also be observed in fermentation, for example, heterolactic fermentation, butyric acid fermentation, and propanoic acid fermentation.".
- Substrate-level_phosphorylation thumbnail Substrate-level_phosphorylation_generating_ATP.svg?width=300.
- Substrate-level_phosphorylation wikiPageID "2027148".
- Substrate-level_phosphorylation wikiPageLength "7408".
- Substrate-level_phosphorylation wikiPageOutDegree "40".
- Substrate-level_phosphorylation wikiPageRevisionID "704607233".
- Substrate-level_phosphorylation wikiPageWikiLink 1,3-Bisphosphoglyceric_acid.
- Substrate-level_phosphorylation wikiPageWikiLink 3-Phosphoglyceric_acid.
- Substrate-level_phosphorylation wikiPageWikiLink Adenosine_diphosphate.
- Substrate-level_phosphorylation wikiPageWikiLink Adenosine_triphosphate.
- Substrate-level_phosphorylation wikiPageWikiLink Catabolism.
- Substrate-level_phosphorylation wikiPageWikiLink Category:Metabolism.
- Substrate-level_phosphorylation wikiPageWikiLink Category:Phosphorus.
- Substrate-level_phosphorylation wikiPageWikiLink Cellular_respiration.
- Substrate-level_phosphorylation wikiPageWikiLink Chemiosmosis.
- Substrate-level_phosphorylation wikiPageWikiLink Citric_acid_cycle.
- Substrate-level_phosphorylation wikiPageWikiLink Creatine_kinase.
- Substrate-level_phosphorylation wikiPageWikiLink Dehydrogenase.
- Substrate-level_phosphorylation wikiPageWikiLink Fermentation.
- Substrate-level_phosphorylation wikiPageWikiLink Flavin_adenine_dinucleotide.
- Substrate-level_phosphorylation wikiPageWikiLink Glycolysis.
- Substrate-level_phosphorylation wikiPageWikiLink Guanosine_diphosphate.
- Substrate-level_phosphorylation wikiPageWikiLink Guanosine_triphosphate.
- Substrate-level_phosphorylation wikiPageWikiLink Lactic_acid_fermentation.
- Substrate-level_phosphorylation wikiPageWikiLink Oxidative_phosphorylation.
- Substrate-level_phosphorylation wikiPageWikiLink Phosphine_oxide.
- Substrate-level_phosphorylation wikiPageWikiLink Phosphocreatine.
- Substrate-level_phosphorylation wikiPageWikiLink Phosphoenolpyruvate_carboxykinase.
- Substrate-level_phosphorylation wikiPageWikiLink Phosphoenolpyruvic_acid.
- Substrate-level_phosphorylation wikiPageWikiLink Phosphoglycerate_kinase.
- Substrate-level_phosphorylation wikiPageWikiLink Phosphorylation.
- Substrate-level_phosphorylation wikiPageWikiLink Pyruvate_kinase.
- Substrate-level_phosphorylation wikiPageWikiLink Pyruvic_acid.
- Substrate-level_phosphorylation wikiPageWikiLink Reactive_intermediate.
- Substrate-level_phosphorylation wikiPageWikiLink Red_blood_cell.
- Substrate-level_phosphorylation wikiPageWikiLink Redox.
- Substrate-level_phosphorylation wikiPageWikiLink Succinate—CoA_ligase_(ADP-forming).
- Substrate-level_phosphorylation wikiPageWikiLink Succinate—CoA_ligase_(GDP-forming).
- Substrate-level_phosphorylation wikiPageWikiLink Transferase.
- Substrate-level_phosphorylation wikiPageWikiLink Wikt:aerobic.
- Substrate-level_phosphorylation wikiPageWikiLink Wikt:anaerobic.
- Substrate-level_phosphorylation wikiPageWikiLink File:Substrate-level_phosphorylation_generating_ATP.svg.
- Substrate-level_phosphorylation wikiPageWikiLinkText "Substrate-level phosphorylation".
- Substrate-level_phosphorylation wikiPageWikiLinkText "substrate phosphorylation".
- Substrate-level_phosphorylation wikiPageWikiLinkText "substrate-level phosphorylation".
- Substrate-level_phosphorylation wikiPageUsesTemplate Template:Confusing.
- Substrate-level_phosphorylation wikiPageUsesTemplate Template:Multiple_issues.
- Substrate-level_phosphorylation wikiPageUsesTemplate Template:Portal_bar.
- Substrate-level_phosphorylation wikiPageUsesTemplate Template:Refimprove.
- Substrate-level_phosphorylation wikiPageUsesTemplate Template:Reflist.
- Substrate-level_phosphorylation subject Category:Metabolism.
- Substrate-level_phosphorylation subject Category:Phosphorus.
- Substrate-level_phosphorylation hypernym Reaction.
- Substrate-level_phosphorylation type Disease.
- Substrate-level_phosphorylation type Redirect.
- Substrate-level_phosphorylation comment "Substrate-level phosphorylation is a type of metabolic reaction that results in the formation of adenosine triphosphate (ATP) or guanosine triphosphate (GTP) by the direct transfer and donation of a phosphoryl (PO3) group to adenosine diphosphate (ADP) or guanosine diphosphate (GDP) from a phosphorylated reactive intermediate. Note that the phosphate group does not have to come directly from the substrate.".
- Substrate-level_phosphorylation label "Substrate-level phosphorylation".
- Substrate-level_phosphorylation sameAs Q910492.
- Substrate-level_phosphorylation sameAs Substratkettenphosphorylierung.
- Substrate-level_phosphorylation sameAs Φωσφορυλίωση_επιπέδου_υποστρώματος.
- Substrate-level_phosphorylation sameAs Fosforilación_a_nivel_de_sustrato.
- Substrate-level_phosphorylation sameAs Substraattitason_fosforylaatio.
- Substrate-level_phosphorylation sameAs Phosphorylation_au_niveau_du_substrat.
- Substrate-level_phosphorylation sameAs Fosforilación_a_nivel_de_substrato.
- Substrate-level_phosphorylation sameAs Fosforilazione_a_livello_del_substrato.
- Substrate-level_phosphorylation sameAs 基質レベルのリン酸化.
- Substrate-level_phosphorylation sameAs m.06g502.
- Substrate-level_phosphorylation sameAs Substrat_düzeyinde_fosforilasyon.
- Substrate-level_phosphorylation sameAs Субстратне_фосфорилювання.
- Substrate-level_phosphorylation sameAs Q910492.
- Substrate-level_phosphorylation sameAs 底物水平磷酸化.
- Substrate-level_phosphorylation wasDerivedFrom Substrate-level_phosphorylation?oldid=704607233.
- Substrate-level_phosphorylation depiction Substrate-level_phosphorylation_generating_ATP.svg.
- Substrate-level_phosphorylation isPrimaryTopicOf Substrate-level_phosphorylation.