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- Stem-cell_niche abstract "Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. The word 'niche' can be in reference to the in vivo or in vitro stem-cell microenvironment. During embryonic development, various niche factors act on embryonic stem cells to alter gene expression, and induce their proliferation or differentiation for the development of the fetus. Within the human body, stem-cell niches maintain adult stem cells in a quiescent state, but after tissue injury, the surrounding micro-environment actively signals to stem cells to promote either self-renewal or differentiation to form new tissues. Several factors are important to regulate stem-cell characteristics within the niche: cell–cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, interactions between stem cells and adhesion molecules, extracellular matrix components, the oxygen tension, growth factors, cytokines, and the physicochemical nature of the environment including the pH, ionic strength (e.g. Ca2+ concentration) and metabolites, like ATP, are also important. The stem cells and niche may induce each other during development and reciprocally signal to maintain each other during adulthood.Scientists are studying the various components of the niche and trying to replicate the in vivo niche conditions in vitro. This is because for regenerative therapies, cell proliferation and differentiation must be controlled in flasks or plates, so that sufficient quantity of the proper cell type are produced prior to being introduced back into the patient for therapy.Human embryonic stem cells are often grown in fibroblastic growth factor-2 containing, fetal bovine serum supplemented media. They are grown on a feeder layer of cells, which is believed to be supportive in maintaining the pluripotent characteristics of embryonic stem cells. However, even these conditions may not truly mimic in vivo niche conditions.Adult stem cells remain in an undifferentiated state throughout adult life. However, when they are cultured in vitro, they often undergo an 'aging' process in which their morphology is changed and their proliferative capacity is decreased. It is believed that correct culturing conditions of adult stem cells needs to be improved so that adult stem cells can maintain their stemness over time.A Nature Insight review defines niche as follows:\"Stem-cell populations are established in 'niches' — specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics ... The simple location of stem cells is not sufficient to define a niche. The niche must have both anatomic and functional dimensions\"".
- Stem-cell_niche wikiPageID "10213576".
- Stem-cell_niche wikiPageLength "42826".
- Stem-cell_niche wikiPageOutDegree "38".
- Stem-cell_niche wikiPageRevisionID "705788789".
- Stem-cell_niche wikiPageWikiLink Adenosine_triphosphate.
- Stem-cell_niche wikiPageWikiLink Adipocyte.
- Stem-cell_niche wikiPageWikiLink Angiogenesis.
- Stem-cell_niche wikiPageWikiLink Arrector_pili_muscle.
- Stem-cell_niche wikiPageWikiLink Autocrine_signalling.
- Stem-cell_niche wikiPageWikiLink Bone_marrow.
- Stem-cell_niche wikiPageWikiLink CDH1_(gene).
- Stem-cell_niche wikiPageWikiLink Calcium.
- Stem-cell_niche wikiPageWikiLink Cancer_Stem_cell_niche.
- Stem-cell_niche wikiPageWikiLink Cap_cells.
- Stem-cell_niche wikiPageWikiLink Cardiovascular_stem_cell_niche.
- Stem-cell_niche wikiPageWikiLink Category:Habitats.
- Stem-cell_niche wikiPageWikiLink Category:Stem_cells.
- Stem-cell_niche wikiPageWikiLink Decapentaplegic.
- Stem-cell_niche wikiPageWikiLink Drosophila.
- Stem-cell_niche wikiPageWikiLink Drosophila_melanogaster.
- Stem-cell_niche wikiPageWikiLink Epithelial–mesenchymal_transition.
- Stem-cell_niche wikiPageWikiLink Feeder_layer.
- Stem-cell_niche wikiPageWikiLink Fibroblast.
- Stem-cell_niche wikiPageWikiLink Gap_junction.
- Stem-cell_niche wikiPageWikiLink Hematopoietic_stem_cell.
- Stem-cell_niche wikiPageWikiLink Hematopoietic_stem_cell_niche.
- Stem-cell_niche wikiPageWikiLink Histology.
- Stem-cell_niche wikiPageWikiLink Hypoxia_(medical).
- Stem-cell_niche wikiPageWikiLink Inflammation.
- Stem-cell_niche wikiPageWikiLink Injury-induced_stem-cell_niches.
- Stem-cell_niche wikiPageWikiLink Juxtacrine_signalling.
- Stem-cell_niche wikiPageWikiLink Liver_sinusoid.
- Stem-cell_niche wikiPageWikiLink Monocyte.
- Stem-cell_niche wikiPageWikiLink Nature_(journal).
- Stem-cell_niche wikiPageWikiLink Oogenesis.
- Stem-cell_niche wikiPageWikiLink Ovariole.
- Stem-cell_niche wikiPageWikiLink Piwi.
- Stem-cell_niche wikiPageWikiLink Sonic_hedgehog.
- Stem-cell_niche wikiPageWikiLink Stem-cell_niche.
- Stem-cell_niche wikiPageWikiLink Stem_cell.
- Stem-cell_niche wikiPageWikiLink Vasa_gene.
- Stem-cell_niche wikiPageWikiLink File:Ovariole_niche.png.
- Stem-cell_niche wikiPageWikiLinkText "Stem-cell niche".
- Stem-cell_niche wikiPageWikiLinkText "stem-cell niche".
- Stem-cell_niche wikiPageUsesTemplate Template:Citation_needed.
- Stem-cell_niche wikiPageUsesTemplate Template:Quote.
- Stem-cell_niche wikiPageUsesTemplate Template:Refimprove.
- Stem-cell_niche subject Category:Habitats.
- Stem-cell_niche subject Category:Stem_cells.
- Stem-cell_niche type Habitat.
- Stem-cell_niche comment "Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate. The word 'niche' can be in reference to the in vivo or in vitro stem-cell microenvironment. During embryonic development, various niche factors act on embryonic stem cells to alter gene expression, and induce their proliferation or differentiation for the development of the fetus.".
- Stem-cell_niche label "Stem-cell niche".
- Stem-cell_niche sameAs Q16729831.
- Stem-cell_niche sameAs Nicchia_staminale.
- Stem-cell_niche sameAs 幹細胞ニッチ.
- Stem-cell_niche sameAs m.02q5d8s.
- Stem-cell_niche sameAs Ниша_стволовой_клетки.
- Stem-cell_niche sameAs Q16729831.
- Stem-cell_niche wasDerivedFrom Stem-cell_niche?oldid=705788789.
- Stem-cell_niche isPrimaryTopicOf Stem-cell_niche.